POSSIBLE MECHANISMS FOR THE RELAXANT OF CARVACROL ON TRACHEAL CHINS

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BOSKABADI M.H.; JANDAGHI P.; SHAH MOHAMMADI -

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Seminar Paper

Paper Information

Seminar: IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY
Year:2009 | Issue:19

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Title

POSSIBLE MECHANISMS FOR THE RELAXANT OF CARVACROL ON TRACHEAL CHINS

Author(s)

BOSKABADI M.H. | JANDAGHI P. | SHAH MOHAMMADI -

Keywords

CARUM COPTICUM

RELAXANT EFFECT

THYMOL

CARVACROL

β2- ADRENERGIC

HISTAMINE H1

Abstract

In our previous studies, the relaxant and anticholinergic, histamin (H1) inhibitory, and xantine-like activity effects of Carum copticum have been demonstrated on tracheal chains of guinea pigs. The relaxant effect of different fractions of essential oil from Carum copticum was also examined. Therefore the relaxant effect of two main costtuent substance of the plant (thymol and carvacrol) was examined in this study to find the possible responsible substance for the relaxant effact of this plant. The relaxant effects of three cumulative volumes (0.02, 0.04, and 0.08ml) of 1/100 diluted carvacrol were examined by their relaxant effects on pre-contracted tracheal chains of guinea pigs by 10 μM methacholine in two different conditions including: non-incubated tissues (group 1) and incubated tissues with 1 μM propranolol and 1 Μm chlorpheniramine (group 2), (for each group, n=5) and were compared with the effects of ethanol and theophylline. The results showed that relaxant effect of all three volumes (concentration) of carvacrol and were significantly higher than those of ethanol and even theophylline (p<0.05 to p<0.001). There was a positive correlation between relaxant effect of carvacrol and increment volumes. The relaxant effect of only first volume of carvacrol obtained in group 2 experiments was significantly greater than that of group 1 (p<0.05). These results indicated that the carvacrol has a potent relaxant effect on tracheal chains of guinea pigs which is not due to b2- adrenergic stimulatory or histamine H1 blocking effect.

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APA: Copy

BOSKABADI, M.H., JANDAGHI, P., & SHAH MOHAMMADI, -. (2009). POSSIBLE MECHANISMS FOR THE RELAXANT OF CARVACROL ON TRACHEAL CHINS. IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. SID. https://sid.ir/paper/903736/en

Vancouver: Copy

BOSKABADI M.H., JANDAGHI P., SHAH MOHAMMADI -. POSSIBLE MECHANISMS FOR THE RELAXANT OF CARVACROL ON TRACHEAL CHINS. 2009. Available from: https://sid.ir/paper/903736/en

IEEE: Copy

M.H. BOSKABADI, P. JANDAGHI, and - SHAH MOHAMMADI, “POSSIBLE MECHANISMS FOR THE RELAXANT OF CARVACROL ON TRACHEAL CHINS,” presented at the IRANIAN CONGRESS OF PHYSIOLOGY AND PHARMACOLOGY. 2009, [Online]. Available: https://sid.ir/paper/903736/en

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