Continuation or termination of metformin in diabetic patients exposed to iodinated contrast medium?

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Dayani Mohamad Ali

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Paper Information

Journal: JOURNAL OF RENAL INJURY PREVENTION Year:2019 | Volume:8 | Issue:3 Page(s): 185-189

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Title

Continuation or termination of metformin in diabetic patients exposed to iodinated contrast medium?

Author(s)

Dayani Mohamad Ali | Issue Writer Certificate

Keywords

Iodinated contrast media

Lactic acidosis

Metformin

Chronic kidney disease

Metformin-associated lactic acidosis

Hypoxemia

Abstract

Lactic acidosis (LA) secondary to Metformin administration is a rare incident with a very high mortality rate (≥ 50%). Hypoxia has been suggested to contribute to Metformin-associated Lactic acidosis (MALA) in 90% of patients developing this condition. In susceptible patients such as those with renal insufficiency, the level of plasma Metformin is increased particularly after exposure to Iodinated contrast media (ICM). One major concern in patients with renal insufficiency is to adjust the Metformin dose based on the renal functional capacity prior to ICM examination. In this review, we assessed Metformin tolerable threshold in diabetic patients with renal failure. We also reviewed Metformin withdrawal criteria in patients with Chronic kidney disease (CKD) exposed to intravenous ICM during angiography. Our results indicated that in patients with insufficient renal function (i. e. 30< estimated glomerular filtration rate(eGFR) <60 and 30

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APA: Copy

Dayani, Mohamad Ali. (2019). Continuation or termination of metformin in diabetic patients exposed to iodinated contrast medium?. JOURNAL OF RENAL INJURY PREVENTION, 8(3), 185-189. SID. https://sid.ir/paper/760420/en

Vancouver: Copy

Dayani Mohamad Ali. Continuation or termination of metformin in diabetic patients exposed to iodinated contrast medium?. JOURNAL OF RENAL INJURY PREVENTION[Internet]. 2019;8(3):185-189. Available from: https://sid.ir/paper/760420/en

IEEE: Copy

Mohamad Ali Dayani, “Continuation or termination of metformin in diabetic patients exposed to iodinated contrast medium?,” JOURNAL OF RENAL INJURY PREVENTION, vol. 8, no. 3, pp. 185–189, 2019, [Online]. Available: https://sid.ir/paper/760420/en

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