A NEW SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF NADOLOL

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ADEGOKE O.A.; IDOWU O.S.; OLANIYI A.A.

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Paper Information

Journal: JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS) Year:2006 | Volume:3 | Issue:3 Page(s): 277-284

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Title

A NEW SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF NADOLOL

Author(s)

ADEGOKE O.A. | IDOWU O.S. | OLANIYI A.A. | Issue Writer Certificate

Keywords

NADOLOL

DIAZO COUPLING

PHENOL ETHER

CDNBD

SPECTROPHOTOMETRY

Abstract

A new spectrophotometric method has been developed for the assay of nadolol in pure form and in tablets. The assay procedure is based on a derivatization methodology employing 4-carboxyl-2,6-dinitrobenzene dizonium ion (CDNBD) as a diazo coupling reagent. The azo dye formed between nadolol and CDNBD absorbed visible light at the wavelength maximum of 416 nm (λmax) demonstrating a bathochromic shift from the absorption maximum of nadolol. Optimization studies established an optimal reaction time of 10 min at 60 oC. The assays were linear over 1.25-10 μg ml-1 of nadolol, and the reaction occurred by a 3:1 reagent/drug stoichiometric ratio. The method is found to be selective and has a lower detection limit of 0.29 μg ml-1. Recovery studies over three days gave mean recovery of 101.4% (RSD 3.0%). This new method has been successfully applied in the determination of nadolol and nadolol/bendroflumethiazide tablets with accuracy and precision similar to the official (USP) HPLC procedure (p > 0.05). The new procedure has the advantages of high sensitivity, lower limit of detection and could find application as an in-process quality control method for nadolol.

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APA: Copy

ADEGOKE, O.A., IDOWU, O.S., & OLANIYI, A.A.. (2006). A NEW SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF NADOLOL. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS), 3(3), 277-284. SID. https://sid.ir/paper/282093/en

Vancouver: Copy

ADEGOKE O.A., IDOWU O.S., OLANIYI A.A.. A NEW SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF NADOLOL. JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS)[Internet]. 2006;3(3):277-284. Available from: https://sid.ir/paper/282093/en

IEEE: Copy

O.A. ADEGOKE, O.S. IDOWU, and A.A. OLANIYI, “A NEW SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF NADOLOL,” JOURNAL OF THE IRANIAN CHEMICAL SOCIETY(JICS), vol. 3, no. 3, pp. 277–284, 2006, [Online]. Available: https://sid.ir/paper/282093/en

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