BIOFABRICATION OF AU NANOPARTICLES FOR PHARMACEUTICAL APPLICATIONS

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ALIMOHAMMADI M.; HONARY SOHEILA; DEHESTANI L.

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Seminar Paper

Paper Information

Seminar: IRANIAN SEMINAR OF ORGANIC CHEMISTRY
Year:2014 | Issue:22

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Title

BIOFABRICATION OF AU NANOPARTICLES FOR PHARMACEUTICAL APPLICATIONS

Author(s)

ALIMOHAMMADI M. | HONARY SOHEILA | DEHESTANI L. | Issue Writer Certificate

Keywords

NANOPARTICLES

SYNTHESIS

PENICILLIUM TALAROMYCOSE

Abstract

BIOFABRICATION BY USING FUNGI IS AN EXCITING RECENT INTEREST TO DEVELOP AN ECO-FRIENDLY PRODUCTION OF METALLIC NANOPARTICLES FOR PHARMACEUTICAL APPLICATIONS. THIS STUDY AIMED TO SYNTHESIZE AND CHARACTERIZE AU NANOPARTICLES BY USING PENICILLIUM TALAROMYCOSE [1] THE FUNGUS PENICILLIUM TALAROMYCOSE WAS GROWN IN FLUID CZAPEK DOX BROTH ON SHAKER AT 28OC AND 200 RPM FOR TEN DAYS. THEN THE SUPERNATANT WAS SEPARATED FROM THE MYCELIA TO CONVERT AUCL4 SOLUTION INTO NANO-GOLD PARTICLES. AFTER 24 HOURS, SYNTHESIZED GOLD NANOPARTICLES WERE CHARACTERIZED BY USING UV-VISIBLE SPECTROSCOP, PCS (PHOTON CORRELATION SPECTROSCOPY), ZETA POTENTIAL, SEM (SCANNING ELECTRON MICROSCOPY), AFM (ATOMIC FORCE MICROSCOPY) AND FT-IR (FOURIER TRANSFORMED INFRARED SPECTROSCOPY). THE UV-VISIBLE SPECTROSCOPY ANALYSIS REVEALED A PLASMON BOND PEAK AROUND 560NM SUGGESTING FORMATION OF NANOPARTICLES. THE SEM, AFM AND PCS SHOWED THAT THE GOLD NANOPARTICLES WERE FORMED FAIRLY UNIFORM WITH SPHERICAL SHAPE AND GOOD MONODISPERSITY WITH THE AVERAGE DIAMETER UNDER 100NM. BESIDES, A NEGATIVE ZETA POTENTIAL WERE FOUND FOR NANOPARTICLES INDICATING THEIR STABILITY IN SOLUTION. THE FT-IR SPECTRA REVEALED THE PRESENCE OF DIFFERENT FUNCTIONAL GROUPS TO GOLD NANOPARTICLES WHICH WERE PRESENT IN THE FUNGAL EXTRACT.THE CURRENT APPROACH SUGGESTS THAT THE RAPID SYNTHESIS OF NANOPARTICLES WOULD BE PROPER FOR DEVELOPING A BIOLOGICAL PROCESS FOR MASS SCALE PRODUCTION. WE BELIEVE THAT DEVELOPMENT OF ECO-FRIENDLY PROCESS FOR THE FORMULATION OF METALLIC NANOPARTICLES IS AN IMPORTANT STEP IN THE FIELD OF APPLICATION OF NANOTECHNOLOGY.

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APA: Copy

ALIMOHAMMADI, M., HONARY, SOHEILA, & DEHESTANI, L.. (2014). BIOFABRICATION OF AU NANOPARTICLES FOR PHARMACEUTICAL APPLICATIONS. IRANIAN SEMINAR OF ORGANIC CHEMISTRY. SID. https://sid.ir/paper/912736/en

Vancouver: Copy

ALIMOHAMMADI M., HONARY SOHEILA, DEHESTANI L.. BIOFABRICATION OF AU NANOPARTICLES FOR PHARMACEUTICAL APPLICATIONS. 2014. Available from: https://sid.ir/paper/912736/en

IEEE: Copy

M. ALIMOHAMMADI, SOHEILA HONARY, and L. DEHESTANI, “BIOFABRICATION OF AU NANOPARTICLES FOR PHARMACEUTICAL APPLICATIONS,” presented at the IRANIAN SEMINAR OF ORGANIC CHEMISTRY. 2014, [Online]. Available: https://sid.ir/paper/912736/en

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