Background and Aim: Non- Steroidal Anti Inflammatory (NSAIDs) medications used for treatment of pain related to orthodontic treatment could slow down tooth movements. Selective cyclooxigenase- 2 inhibitors are alternatives to conventional non steroidal drugs. The aim of this study was to compare three different doses of celecoxib on orthodontic tooth movement and root resorption in Rats.Materials & Methods: Forty male Rats randomly divided in to the following groups; D (the application of orthodontic appliance with taking medications); E (without any intervention) and experimental groups included A (received 25 mg/kg), B (received 50 mg/kg) and C (received 100 mg/kg) dose of celecoxib. NiTi coil spring was ligated between the right side maxillary incisor and 1st molar. The animals were sacrificed after two weeks and distance between 2 teeth was measured with Caliper. After preparation of histological sections, amount of root resorption, numbers and maximum depth of resorption lacunae in mesial root surfaces of molar was measured. Data were analyzed with ANOVA, LSD and Tukey HSD.Results: The maximum tooth movement was found in group A (0.8537 mm), D, C, B and E respectively. Statistical analysis did not show any significant difference between the different doses of celecoxib drug in tooth movement. The usage of celecoxib (particularly in higher doses; 100 mg/kg) decreased the number of resorption lacaunae in mesial root of first maxillary molar (P<0.05).Conclusion: 100 mg/kg dose of celecoxib was found to be optimum for the lowest effect on tooth movement and the most protection against root resorption.

Introduction: Effective pain management after dental surgeries is one of the most common problems in dentistry. Ibuprofen is the most common non selective non steroidal anti-inflammatory drug (NSAID), which inhibits both COX-1 and COX-2. celecoxib is a COX-2 specific NSAID and also the only COX-2 specific drug available in Iran. Naproxen is a non selective NSAID that is often used for postoperative pain management all around the world; however, it is not the first choice in our country. The purpose of this study was to compare the effectiveness of celecoxib, Naproxen, and Ibuprofen in pain control after periodontal surgery.Materials & Methods: This double-blind clinical trial study included a total of 30 patients who presented with chronic periodontitis and who underwent surgical procedures on the anterior sextant of the mandible. They were randomly assigned to 3 groups of 10 patients. Each group received one of the following medication protocols: Group A: 400 mg Ibuprofen, group B: 200 mg celecoxib , Group C: 250 mg Naproxen. Patients reported their pain levels using a VAS (visual analog scale) at 1, 3, 6, 12, 24, and 48 hours after periodontal surgery. All data were analyzed by SPSS Ver 15 program. Data were analyzed using Kruskal-Wallis and Mann-Whitney tests, respectively.Results: Statistical analysis of the data showed no significant differences between Ibuprofen, celecoxib, and Naproxen after 1, 6, 12, 24, or 48 hours after the surgery. Significant differences were seen only at the third hour after surgery between celecoxib and Naproxen and between Ibuprofen and Naproxen.Conclusion: Considering the lower rate of side effects of celecoxib its similar degree of pain reduction as Ibuprofen, and its better efficiency than Naproxen, celecoxib can be considered an appropriate drug for pain control after periodontal surgeries.

Background: Wounds and their healing process are among the most crucial medical issues, especially in the field of dermatology and surgery that imposes notable costs to the health care system. Materials and Methods: Wound healing requires specific fundamental steps, such as angiogenesis and inflammation. Angiogenesis is controlled by different cytokines such as Hypoxia-Inducible Factor α (HIF-α ), Vascular Endothelial Growth Factor (VEGF), basic Fibroblast Growth Factor (bFGF), Platelet-Derived Growth Factor (PDGF), Tumor Necrosis Factor α (TNF-α ), and Matrix MetalloProteinases (MMPs). Results: celecoxib, an inhibitor of Cyclooxygenase-2 (COX-2), is widely used in medicine and different fields. This medication can inhibit angiogenesis via suppressing all mentioned cytokines. Thus, suppression of angiogenesis by celecoxib, especially in chronic wounds, may result in the poor or delayed healing. Conclusion: Authors suggest complementary clinical studies to evaluate the possible role of celecoxib on the wound healing focusing on angiogenesis.

Objective: celecoxib is a nonstroidal anti-inflammatory drug .This is a selectiveCox-2 inhibitor.Nowadays this drug uses as an analgesic, antipyretic and anti-inflammatory agent frequently. In some patients that used celecoxib for a long time, unusual effect of this drug may be seen. The goal of this survey is assess the effect of this drug on male-reproductive system functions.Materials and Methods: This survey done for study of effect of celecoxib on rat reproductive system, specially on spermatogenasis and the level of blood testosterone hormone. In this manner histologic studies and measuring of weight (testis, prostate, seminal vesicle and epidydimis) and the level of blood testestron are done. 50 rat with 200-230 gr. weight selected and compared in 5 groups.control group (no drug given), sham group (solvent drug: Di- methyl sulfoxide), 3 cases group (orally celecoxib 10, 20 and 40 mg/kg given daily) for 15 days. In the end of 15 days heart blood sampling for measuring serum testestron level accomplished after that reproductive systems separated and prepared for histologic study.Results: Result showed no significant differences in mean weight of body testis, epidydimis and seminal vesicle in control and case groups. But significant differences are seen in the mean weight of prostate per body weight in case group (40 mg/kg) in compared with control group. That is due to antimalignant effect of celecoxib on prostate. No differences seem between control and case groups in arrangement mode, nuclei shape and cytoplasm in histologic examination in spermatogonia and primary spermatocytes in transverse section of seminiferous tubules celecoxib in case group (40 mg/kg) can decrease lydige cells number, that is due to inhibited prostaglandin synthesise, for the result of cox-2 inhibitor and decreased level of testosterone hormone.Conclusion: It looks that number of sertoli cells in control and case groups are differences. So that in case group (40 mg/kg) number of sertoli cells decreased due to decrease testestron level. This can cause production of abnormal sperms. In the survey can conclude that use of high doses of celecoxib can decreased size and number of lydig cells and this is cause of decreased testosterone hormone.

Background &Aim: This double - blind clinical study compared the pain reducing effect of celecoxib and Ibuprofen in patients with severe endodontically originated pain.Methods &Materials: A total of 30 patients presenting with severe pulpally originated pain consented to a single - dose oral administration of 100 mg of celecoxib or 400 mg of Ibuprofen.Patients - reported Visual Analog Scale (VAS) ratings of pain intensity were recorded at every 15 min for 90 min after drug administration. Data were analyzed using student's t test.Results: Results indicated that at the 15, 30, 45, 60 and 75 min periods, both celecoxib and Ibuprofen provided pain relief, but there was no significant difference between them. At 90 min period, celecoxib showed significantly better pain relief than Ibuprofen (P<0.01).Conclusion: Based on the results of this study, it seems that celecoxib has better pain reducing effect than Ibuprofen.

Objective(s): celecoxib acts through both COX-2-dependent and -independent pathways. According to the paradoxical effect of NO on the inflammatory and nociceptive signal processing, the present study designed to evaluate the probable contribution of NO in the analgesic and anti-inflammatory properties of celecoxib.Materials and Methods: Different intensities of inflammatory pain were induced by acute and chronic sc administration of 1%, 2.5%, or 5% formalin and spectrophotometrical analysis of the serum nitrite was performed. Then, in the pretreatment process, the effect of celecoxib (10, 20, or 40 mg/kg/ip) was evaluated on the inflammatory pain induced-nitrite. Also, the effect of celecoxib alone (under non-inflammatory condition) was evaluated on the peripheral NO production and the results compared with that of the vehicle.Results: Formalin-induced inflammatory pain led to an enhancement of the serum nitrite in intensity- and time-dependent manners. celecoxib (40 mg/kg/ip), except its ineffectiveness on the nitrite level, induced 1.5 hr after 5% formalin, reduced production of formalin-induced nitrite in other cases. Meanwhile, under non-inflammatory condition, 1.5 hr after the administration of celecoxib (40 mg/kg/ip), a considerable elevation of nitrite was observed. celecoxib 10 or 20 mg/kg/ip did not show a significant effect on either inhibition or stimulation of the peripheral NO.Conclusion: NO is involved both in the inflammatory and non-inflammatory conditions. It seems that celecoxib exerts a dual effect on the peripheral NO production; it prevents overproduction of NO due to the induction of inflammatory pain, while, it stimulates NO synthesis at the early stage of its action.