Background and purpose: Aim of this research is to study the effect of bridging collateral vessels (BCVS) on the success of coronary angioplasty in patients with chronic total occlusion (CTO). In coronary angioplasty of CTO cases, categorizing of lessions characteristics can be helpful in evaluation of success in angioplasty. There are controversies about the role of BCVS in the rate of angioplasty success in OTC cases.Materials and methods: Seventy seven patients with angioplasty done in CTO lesions were selected for study, and divided in two groups. In the first group comprising of 97 patients, there was BCVS, and the second group (50 patients) had no BCVS.Results: Success was achieved in 11 patients from Group II (40.7% vs 82% p=0.0002 with relative risk of 3.9, and confidence interval of 95%, (1.7 to 6.4). Of 52 patients with successful angioplasty, rate of success with estimation of less than three months occlusion was more in patients with occlusion for more than three months (63.5% vs 47.5%), p=0.0001 and relative risk of 1.8, with confidence interval of 95%, (1.3 to 2.6). Presence of a side branch at the distance of ≥ 2mm to the occlusion point has been one of the predictor factors for unsuccessful angioplasty (p=0.0007, relative risk 2.9, with confidence interval of 95%, (1.5 to 5.6).Conclusion: Presence of some morphological variables in CTO during angioplasty of coronary vessels may be helpful in guiding successful angioplasty. One of them is presence of BCVS which seems to have inverse relation to the rate of successful angioplasty.