Background and Objectives: Acute lymphoblastic leukemia (ALL) is the most common malignancy in childhood. The prevalence of ALL is 1 to 4.7 per 100,000 population every year world-wide. Long non-coding RNAs (LncRNAs) are a group of non-coding RNAs involved in many biological processes, such as epigenetic changes, regulation of mRNA TRANSCRIPTion and translation. Identification of their function can be helpful to understand the pathophysiology and treatment of ALL. One of the important LncRNAs in hematopoiesis regulation is HOTAIR (LncRNA HOX TRANSCRIPT antisense RNA). The purpose of this study was to determine the expression of HOTAIR LncRNA in newly diagnosed B-ALL patients.Materials and Methods: In this cross-sectional descriptive study, 40 newly diagnosed B-ALL patients as well as 15 healthy individuals as control were given 1mL of bone marrow specimen with EDTA anticoagulant. RNA (patients and control) was extracted and Real-time quantitative PCR was used to examine the expression of LncRNA HOTAIR in ALL patients. The results was analyzed by REST 2009.Results: The findings showed that expression of HOTAIR in patients with Acute Lymphoblastic Leukemia type B increased significantly as compared to healthy controls (p˂0.05).Conclusions: In conclusion, the increase expression of HOTAIR in acute lymphoblastic leukemia can be attributed to potential role of LncRNA HOTAIR in pathophysiology of the disease.

To investigate the effects of synchronous and asynchronous interlingual and intralingual TRANSCRIPT presentation on L2 vocabulary comprehension and production, 120 first-year B.A students of English translation at IKIU (Imam Khomeini International) University in Qazvin and Islamic Azad university of Karaj were randomly assigned to 4 groups. Each group was presented with 50 minutes of a film with different TRANSCRIPT conditions – synchronous interlingual, asynchronous interlingual, synchronous intralingual, and asynchronous intralingual TRANSCRIPTs. The participants' vocabulary comprehension was tested using a multiple-choice test and their ability to produce the new words was assessed by utilizing a fill-in-the-blank test. The results of the comprehension test suggested that TRANSCRIPT presentation had no significant effect on the learners' comprehension, although descriptive statistics showed that the participants of the intralingual group performed better than the interlingual group participants, and in both groups, the students got better scores while TRANSCRIPT was presented asynchronously. In addition, the results of the production test indicated that neither the language of the TRANSCRIPT nor the time of TRANSCRIPT presentation had any significant effect on vocabulary production of the students.

Background: Breast cancer is the most frequent cancer in women. Cancer/Testis antigens are immunogenic proteins ectopically expressed in human neoplasms. Synaptonemal complex protein 3 (SYCP3) belongs to cancer/testis genes family involved in meiotic events and spermatogenesis. The aim of this study was to express analysis of SYCP3 in breast cancer and validate it as a breast cancer biomarker.Methods: Expression of SYCP3 TRANSCRIPTs in 47 breast tumors, 6 breast cancer cell lines (MCF7, SKBR3, T47D, BT474, MDA-MB-231 and MDA-MB 468), 5 normal breast and 2 testis tissues was studied by Real Time RT-PCR reaction. The reference genes phosphoglucomutase 1 and hypoxanthine guanine phosphoribosyl transferase were used as reactions normalizers. The software tool REST 2009 was applied for statistical analysis of the data. The research was conducted from Apr 2014 to August 2015 in Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.Results: All of the studied breast cancer cell lines showed very high levels of SYCP3 overexpression in comparison to normal breast (P=0.001) and even to normal testis (P=0.001), except for MCF7 cell line. Breast tumors showed moderately increasing in TRANSCRIPT changes in comparison to normal breast.Conclusion: SYCP3 is a known testis-specific gene, but interestingly five out of six studied breast cancer of cell lines showed higher expression levels of SYCP3 in comparison to normal testis and normal breast tissues. SYCP3 has critical role in cell division with known interaction with the tumor suppressor genes, BRCA1 and BRCA2, which are critical genes in breast cancer.

Objectives: This research, relying on the theoretical theme of the spatiality of social relations, attempts to have a qualitative analysis of the subjective construction of female teachers in formal and informal spaces in Kamyaran City. The theoretical approach is taken from a critical tradition which focuses on the centrality of the society and analyzes subjectivity in the context of space. Methods: For data collection, direct observation and in-depth interview were used. For data analysis, the method of thematic analysis was used. Results: The findings have been categorized under 4 main themes and 20 sub-themes. It was concluded that female teachers adopt themselves to the formal space of schools through a kind of public TRANSCRIPT. However, they secretly resist school’, s disciplinary mechanisms by means of a hidden TRANSCRIPT. On the contrary, in informal spaces, female teachers use public TRANSCRIPT not as a means to adopt themselves to the disciplinary mechanisms but as a way of expressing their own femininity. They actually try to represent their feminine self through participating in intimate gatherings, communicating with the opposite sex and enjoying leisure time. Conclusion: In other words, in informal spaces, women’, s attempt to construct a hidden TRANSCRIPT for self-defense decreases, and their attempt to empower their feminine agency increases, something which is usually realized through activities such as face de-masking, bodily representation and seizing existent spaces.