BACKGROUND: THE COMPARISON OF SUPERHEATED HEXANE EXTRACTION (SHHE), SOXHLET AND COLD PRESS METHOD OF POMEGRANATE SEED OILS WITH RESPECT TO THE FATTY ACID PROFILES SHOWED THAT AMOUNT OF PUNICIC ACID IS IN RANGE OF 69.79-81.69%. [1]. A SECOND ORDER CENTRAL COMPOSITE DESIGN WAS USED TO EVALUATE THE INFLUENCE OF WALL MATERIALS ON YIELD AND EFFICIENCY OF THE SPRAY-DRYING BUTTER MICROENCAPSULATION PROCESS [2], SUNFLOWER OIL (SO) [3] MACADAMIA OIL [4] AND FLAXSEED OIL [5]. MICROENCAPSULATION OF EXTRA VIRGIN OIL BY SPRAY-DRYING USING DIFFERENT WALL COMPONENTS HAS BEEN REPORTED [6]. THE OBJECTIVE OF THIS WORK WAS TO STUDY THE INFLUENCE OF SOME PROCESS CONDITIONS ON THE MICROENCAPSULATION OF POMEGRANATE SEED OIL BY SPRAY DRYING.  METHODS: THE PROCESS WAS CARRIED OUT ON A MINI SPRAY DRYER. COLD PRESS POMEGRANATE SEED OIL (PSO) WAS PREPARED FROM ZAIT KERMAN CO. (KERMAN, IRAN) AND MIX OF SODIUM CASEINATE AND GUM ARABIC WERE USED AS WALL MATERIALS. THE RESPONSE SURFACE METHODOLOGY (RSM) WAS EMPLOYED TO OPTIMIZE THE MICROENCAPSULATION CONDITION OF POMEGRANATE SEED OIL AS TYPICAL SEED OIL. SEVENTEEN TESTS WERE PERFORMED. INDEPENDENT VARIABLES WERE SODIUM CASEINATE CONCENTRATION IN WALL MATERIAL (X1), RANGE 5-20%; EMULSION SOLID (X2), RANGE 10-30%; AND OIL CONCENTRATION RELATED TO EMULSION SOLIDS (X3), RANGE10-30%. WITH RESPECT TO THESE THREE VARIABLES MICROENCAPSULATION EFFICIENCY (MEE) AND MICROENCAPSULATION YIELD (MEY) WAS INVESTIGATED FOR EACH EXPERIMENT.RESULTS: RESULTS SHOWED THAT HIGHER SOLID CONTENT (30%) AND LOWER OIL CONCENTRATION (10-13%) LED TO HIGHER YIELD. ON THE OPTIMUM CONDITIONS, MEY_85% AND MEE_90% WERE OBTAINED AN EMULSION OF X1=13.48%, X2=30% AND X3=10%. THE QUALITY OF MICROCAPSULES AND MORPHOLOGY OF MICROCAPSULES WAS STUDIED WITH SCANNING ELECTRON MICROSCOPY (SEM). ALL MICROCAPSULE PARTICLES WERE WRINKLES ON THE SURFACE. ALSO MEAN PARTICLE SIZE OF MICROENCAPSULATED POWDER DETERMINED ABOUT 4-6M BY SEM.CONCLUSION: RSM WAS USED TO OPTIMIZE THE MEE AND MEY OF POMEGRANATE SEED OIL BY SPRAY DRYING AND DETERMINE THE OPTIMUM CONDITIONS. OBTAINED DATA AT THE OPTIMUM CONDITION, FOR MEY AND MEE OF MICROENCAPSULATION WERE 85.16, 90.91% RESPECTIVELY.