Today, medicinal herbs have been widely used due to antimicrobial, antioxidant properties and less harmful than of chemical compounds. Since ancient times, the medical system in different countries such as Africa, China, India and the Middle East countries, FRANKINCENSE has been used as antiinflammatory, anti-arthritic, analgesic and anti-proliferation in the treatment of related diseases, chronic diseases of the bowel, asthma, brain edema and other diseases. Several clinical studies that have shown their biological activity the mechanism of action of this plant, have confirmed their anti-inflammatory and anti-tumor activities. Boswellic acids, are the main active component of FRANKINCENSE and responsible for its therapeutic effects. This review was studied the therapeutic effects of FRANKINCENSE using the keywords FRANKINCENSE, boswellic acid, anti-inflammation, intestinal diseases, cancer, diabetes, asthma, brain tumor, fertility and memory. FRANKINCENSE with anti-inflammatory, anti-arthritis, anti-proliferative, antimicrobial and analgesic effects at the least side effects and recommended dose could reduce the symptoms of many diseases in traditional and modern medicine.

Introduction: FRANKINCENSE has been shown to possess anti-inflammatory activity. In this study the effect of pretreatment with the hydro-alcoholic extract of FRANKINCENSE on memory retrieval was assessed in lipopolysaccharide (LPS) treated rats.Methods: Forty-two adult male Wistar rats were distributed into 7 groups of 6 each. One group received LPS (1 mg/kg; i.p) pre-test. The control group received saline (1 ml/kg; i.p).2 groups of animals received FRANKINCENSE (50 mg/kg; P.O) or DMSO 5% (1 ml/kg; P.O) and 30 minutes later LPS (1 mg/kg; i.p). Two other groups of animals received FRANKINCENSE (50 mg/kg; P.O) or DMSO 5% (1 ml/kg; P.O) and 30 minutes later saline (1 ml/kg; i.p). Another group of rats received LPS (1 mg/kg; i.p) and 30 minutes later Ibuprofen (100 mg/kg; P.O). In all the experimental groups, memory retrieval was assessed 4 hours following the last injection, using a passive avoidance task (PAT). Hippocampal TNF-α levels were measured by ELISA as an index of LPS-induced neuroinflammation.Results: LPS impaired memory retrieval by decreasing step-through latency (STL), significantly. LPS also increased levels of TNF-a in the hippocampus as compared to the control group. Administration of FRANKINCENSE (50 mg/kg; P.O) before LPS (1 mg/kg; i.p) improved memory retrieval as compared to the control group. FRANKINCENSE reduced hippocampal TNF-a level in the LPS treated rats, significantly, compared to the control group.Conclusion: The results indicate that the hydro-alcoholic extract of FRANKINCENSE has the potential to improve memory retrieval in LPS treated rats, possibly via an anti-neuroinflammatory activity.

Introduction: Ischemic stroke is the most common cause of stroke, paralysis and movement disorders are the most symptoms of stroke. Therefore, it is important to find amethod for improving the disorders. This study aimed to examine the clinical efficacy of FRANKINCENSE in patients with the acuteisc hemic stroke.Materials & methods: In this clinical trial, 06 patients with ischemic stroke were randomly allocated into the treatment and control groups (n=30). In the treatment group, in addition to routine treatment of stroke, four capsules containing 500 mg powdered FRANKINCENSE were given each day, but in the control group, were performed only the treatment of stroke (noFRANKINCENSE) was performed. Thetreat ment lasted for 1 month. The NIHSS scale (for assessment of speech and muscle strength) at the beginning, the seventh dayand the end of the study for each patient was completed. Statistical analysis was performed using independent t-test, chisquare, and Mann withney in SPSS software.Findings: Results showed that only improvement of muscle strength in patient sleft limb increased significantly in stage IIin the treatment group than the control group.Discussion & conclusions: AddingFRANKINCENSE to treatment of patients with stroke can be effective on improvementmuscle strength in patients with muscle weakness and non-dominant side in acuteneurological disorders while that is not effective on improving muscle strength ofthe right limb or speech.