Background: Antacids are the most commonly used medications for fast symptomatic relief of gastric disorders. Because of adverse effects, low efficiency and the high cost of some chemical antacids, identifying a natural medicine with high efficiency and low cost seems useful. Therefore, the aim of the present study was to prepare antacid tablets from Cuttlefish bone and assessment of its antacid properties. Methods: 24 different formulations of cuttlefish bone were prepared by direct compression using different fillers (starch, cellulose, lactose, and mixture of those) in different ratios of the drug. Characterization of powders and tablets was done on all formulations and marketed dosage forms (calcium carbonate and Al-Mg). Results: Weight uniformity, hardness, and friability of all formulations were in acceptable range. Tablets prepared by calcined CUTTLEBONE disintegrated in longer time due to their higher hardness which were mostly higher than 5 Kg. Also, disintegration time of formulations 50-50 (lower dose of CUTTLEBONE) was less than other tablets (2 minutes or less). Results of antacid capacity showed that formulations 90-10 and 80-20 raise the acidic pH of the medium above 7. 5, which were the same as or more than the capacity of the marketed tablets. Conclusion: Tablets were prepared by 90 or 80% of either calcined or non-calcined CUTTLEBONE showed the highest antacid capacity.

Background: CUTTLEBONE is composed mostly of CaCO3 and chitin, and can be used as a natural source of CaCO3 nanoparticle production. Materials and Methods: In this study, ball milling and dispersion of initial powder in a surfactant, cetyl trimethyl ammonium bromide (CTAB) aqueous solution were used to produce CaCO3 nanoparticles from CUTTLEBONE (Sepia pharaonis) of the Persian Gulf. Then, the results of the two methods were compared. Field Emission Scanning Electron Microscopy (FESEM) and Dynamic Light Scattering (DLS) were used to characterize particles. Results: The results showed that two hours grinding of the initial powder produced nanoparticles of 44 nm diameter. Moreover, increasing the grinding time had a direct effect on reducing the size of the nanoparticles. The obtained results from dispersion of initial powder in surfactant aqueous solution indicated the great result of nanoparticles of 40 nm diameter. Conclusion: The capability of CUTTLEBONE powder (Sepia pharaonis) of the Persian Gulf to produce nanoparticles in a process characterized with low energy consumption and low processing time suggests that it may be used at industrial scale for the synthesis of biocompatible nanoparticles.