Background: Soft tissue CHONDROMA is a rare slow-growing benign cartilage forming tumor. Tumors of this kind arise from the relative mesenchymal tissue and have tendency to occur in the fingers and toes. Due to its rarity, this tumor is likely to go undiagnosed. Histopathological examination usually reveals the correct diagnosis.Case presentation: Hereby, we report a case of soft tissue CHONDROMA in a 27 year-old woman presented with a slow-growing mass in the volar aspect of her right hand. The tumor had developed over a 7-month period. The skeletal system was unremarkable on X-ray evaluation. The lesion was excised and the histopathological findings revealed a well-delineated cartilaginous neoplasm with lobular pattern. The tumor was composed of mature chondrocytes without atypia and the findings were compatible with CHONDROMA.Conclusion: There are various hypotheses about the etiology of soft tissue CHONDROMAs and their microscopic findings are variable. They have a good prognosis. Recurrence is rare and malignant transformation has not been reported yet.

We describe a rare case of intradural CHONDROMA. A 28year-old man presented with headache and left hemiparesis. Axial brain computed tomography showed a large lobulated and calcified mass in the right frontal convexity. He was operated and the tumor was completely removed through a frontotemporal craniotomy. The tumor was totally intradural Histopathology examination revealed hyaline lobules of mature cartilaginous tissue compatible with a CHONDROMA.

Introduction: CHONDROMA is a benign cartilaginous tumor. It is found very rarely in the head and neck. Case presentation: This report describes a 25-year-old woman who presented with generalized headache from 4 months ago. The patient underwent excisional surgery. The histological examinations revealed benign cartilage forming tumor, compatible with CHONDROMA. The radiologic and histologic correlation confirmed the diagnosis. Based on the diagnosis, the patient received no more treatment. Conclusion: We concluded that intracranial CHONDROMA should be included in the differential diagnosis of a calcified mass on skull imaging. Proper diagnosis is necessary for further patient management.

CHONDROMAs are benign tumors that may be found in many parts of the body. Among intracranial neoplasms, tumors of cartilaginous origin are rare. It has been shown that most of these tumors arise from the skull base. Their occurrence in other parts of the intracranial cavity is unusual. CHONDROMA of falx is a rare neoplasm. In this report we introduce a case of falcine CHONDROMA arose from frontal midline area in a 17-year-old boy.

CHONDROMA is a benign tumor which mostly occurs in extremities but also sometimes in brain.Most intracranial CHONDROMAs arise from skull base, but CHONDROMA of falx origin is a rare circumstance.Indeed, the intracranial CHONDROMAs rise from falx is mostly in relation with syndromic disorders such as Mafucci’s syndrome or Ollier’s syndrome. Here, we reported a rare case of falxian intracranial CHONDROMA in a young man who has normal physical examination and no signs of any syndromic disorder. The goal of this paper was to raise awareness about CHONDROMAs and suggest that CHONDROMA be ruled out in any patient with masses arising from falx.

EnCHONDROMA is a kind of bone hamartoma and a benign hyaline cartilage tumor. Although it is the most common benign tumor of bone, it is quite rare in the spine, especially the lumbar spine. We report a case of CHONDROMA that was located in the lumbar spine, which extended from L2 to L5 in a 4. 5-year-old child. He visited our clinic with a complaint of spine deformity and limping for 3 years. Surgical resection of large ossified mass was performed and pathologically confirmed to be a benign hamartoma of hyaline cartilage with enchondral ossification. Resection of mass released the tethering effect and balanced the growth speed of spine bilaterally. It is suggestive of a congenital developmental malformation with hamartomatous features and reactive changes.

Cartilaginous tumors comprise 1% of all laryngeal masses. Since they grow slowly and metastasis is rare, long term survival is expected in cases of CHONDROMA and chondrosarcoma. Thus, based on these facts and the fact that total salvage surgery after recurrence of previous tumor does not influence treatment outcomes, "Quality of Life" must be taken into great consideration. Based on 3 cases of limited condrosarcoma that we have successfully operated on using submucosal delivery through a parapharyngeal approach, after several years of recurrence free follow ups, authors determine this technique as an efficient method of approach to these tumors. Since this technique takes less time and there is no need for glottic incision and the patient is discharged in 2 days without insertion of endolaryngeal stent, we believe this method is superior to laryngofissure or total laryngectomy.

Background: EnCHONDROMA is the most common benign bone tumor in hand, which can be seen in various manifestations such as swelling, pain, deformity and pathologic fracture. Different surgical treatments were reported for enCHONDROMA to prevent the progressive deformity and pathological fractures. The purpose of this study was to investigate the result of treatment of enCHONDROMA of hand with curettage alone.Methods: In a cross sectional study, 17 patients with average age of 32 years with enCHONDROMA of hand who were operated in a 6-year period in a training hospital in Tehran-Iran were evaluated. The patients received the treatment of tumor removal without filling the resultant defect. The cases were evaluated for range of motion, grip power and radiographic Tordai classification.Results: In a 15.2 month (12-88 months) follow-up no recurrence was observed and all of the patients re-gained their previous finger range of motion.Conclusion: Treatment of enCHONDROMA of hand with curettage alone, without filling the defect would result in satisfactory outcome with low recurrence rate and good restoration of power and function.

Background and Aim: CHONDROMA and well-differentiated chondrosarcoma have very similar histopathologic features. In spite of this similarity, their biologic behavior is different. Pathologic misdiagnosis leads to inaccurate treatment plan and unwanted wide surgery. The role of immunohistochemical markers in differential diagnosis of chondroid tumors have considered. The aim of this study was histopathologic differentiation between CHONDROMA and well-differentiated chondrosarcomas by using Bcl-2 marker with immunohistochemical method and determination a proper Cut off point. Materials & Methods: The study was descriptive, analytical retrospective one. The histopathologic records with CHONDROMA and well-differentiated chondrosarcoma diagnosis were obtained from pathology Dept. , Cancer Institute, Imam Khomini hospital from 1370 to 1385 .6 CHONDROMA and 11 well-differentiated chondrosarcoma were retrieved. The formalin – fixed paraffinized blocks were examined immunohistochemically for Bcl-2 expression .The labeling Index (LI= stained tumoral cells /1000 chondrocytes) were calculated for each tumor. The mean of LI for CHONDROMA and well-differentiated chondrosarcoma groups were obtained. T test was used for statistical analysis. Results: The LI mean of CHONDROMA and well-differentiated chondrosarcoma were 17.72±7.12 and 37.19±12.32, respectively. The Bcl-2 expression between two groups was statistically significant (P=0.004). The ROC curve was obtained as 0.886. The Cut off point=30 were considered with 100% specificity and 81.8% sensitivity. Conclusion: Bcl-2 is a proper, significant marker for CHONDROMA vs. well-differentiated chondrosarcoma diagnosis.

Introduction: Intracranial CHONDROMA and chondrosarcoma are very rare tumors that mainly originate from the base of the skull. Advanced neuroimaging studies, including magnetic resonance spectroscopy (MRS), play a pivotal role in both tumor diagnosis and presurgical planning. Case Presentation: We present two cases of intracranial cartilaginous tumors, including a CHONDROMA and a chondrosarcoma, both of which presented with severe headaches. Due to inconclusive conventional MRI and MRS results, they were both primarily diagnosed as intra-axial brain tumors. However, pathological reports later confirmed the diagnosis of a CHONDROMA and a chondrosarcoma. Conclusion: Based on the present findings, the use of advanced neuroimaging techniques, such as MRS, may improve diagnostic accuracy. We believe that MRS can play a significant role in the surgical planning of similar cases. Also, reporting rare cases worldwide can contribute to the improvement of radiographic diagnosis.