Background: Predisposing lesions of retinal detachment result in severe complications in case of leaving untreated, so the present study has been conducted to determine the results of prophylactic treatment of retinal detachment in patients referring to Emam Hossein hospital since 1992 till 2000. Materials and methods: This study of existing data type was performed on patients undergone prophylactic treatment (lasertherapy and cryoterapy) who had passed follow up of at least three months. Personal characteristics, variables of predisposing lesions, complications and the necessity of additional treatment were all determined. Finally, statistical analysis was done. Results: Totally, 201 patients had undergone treatment, where 76 patients with 88 lesions were studied. Overall success rate of 89.5% was achieved. The reason of further additional treatment (26%) were new breads in 14 (16%) eyes, inadequate initial treatment in 6 (7%) and retinal detachment in 7 (8%). New breads were accompanied by retinal detachment in 4 patients, so their percents were overlapped. Considering the failure of treatment, no significant difference was found between the subgroups; however, failure rate seems to be a little bit higher in aphakic, pseudoaphakic and patients with vitreous hemorrhage. Conclusion: With respect to the high success rate achieved in our study, prophylactic treatment for the predisposing lesions of retinal detachment is strongly recommended. Meanwhile, considering the necessity of additional treatment in most of the patients, longer period of follow up seems to be inevitable. We suggest another clinical trial with greater samples.