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Information Seminar Paper

Title

THE APPLICATION OF CENTRALITY MEASURES IN BIOLOGICAL NETWORK ANALYSIS

Writers

RAEISI VANANI SADEGH | RAZZAGHI MOGHADAM KASHANI ZAHRA | JAMALI YOUSEF

Pages

 Start Page | End Page

Abstract

 TOPOLOGICAL ANALYSIS OF BIOLOGICAL NETWORKS GIVES INSIGHTS INTO BIOLOGICAL PROCESSES. ONE OF THE USEFUL METHODSIN THIS FIELD IS THE NOTION OF CENTRALITY ANALYSIS THAT EVALUATES THE SIGNIFICANCE OF VERTICES WITHIN THE CONNECTION STRUCTURE OF THE NETWORK. IN THIS PAPER, DIFFERENT CONCEPTS OF CENTRALITY ON DIFFERENT TYPES OF BIOLOGICAL NETWORKSARE APPLIED TO CLARIFY THE MOST SIGNIFICANT ELEMENTS IN BIOLOGICAL PROCESSES. IT IS DEMONSTRATED THAT SOME DIFFERENT CENTRALITY MEASURES RESULT IN COMMON VALUATION OF THE VERTICES, WHILE SOME OTHERS MAKE DISTINGUISHED SIGNIFICANCES. ADDITIONALLY, A NEW CENTRALITY MEASURE CALLED K-PATH CENTRALITY IS APPLIED ON BIOLOGICAL NETWORKS. THE RESULTS INDICATETHAT THIS CENTRALITY CAN BE SUBSTITUTED FOR BETWEENNESS CENTRALITY AND FASTER EVALUATION WILL BE ACHIEVED.

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