IN SITU SURFACTANT MODIFIED GRAPHENE OXIDE NANOSHEETSELECTRODE FOR ELECTROCHEMICAL INVESTIGATION OF CLOZAPINE

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ARVAND M.; ALIJANI H.

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Seminar Paper

Paper Information

Seminar: IRANIAN BIENNIAL ELECTROCHEMISTRY SEMINAR
Year:2014 | Issue:11

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Title

IN SITU SURFACTANT MODIFIED GRAPHENE OXIDE NANOSHEETSELECTRODE FOR ELECTROCHEMICAL INVESTIGATION OF CLOZAPINE

Author(s)

ARVAND M. | ALIJANI H. | Issue Writer Certificate

Keywords

CLOZAPINE

SURFACTANT

GRAPHENE OXIDE NANOSHEETS

MODIFIED ELECTRODE

VOLTAMMETRY

Abstract

CLOZAPINE (CLZ) IS AN ATYPICAL ANTIPSYCHOTIC DRUG. THIS DRUG IS VERY EFFECTIVE AGAINST BOTH THE NEGATIVE AND POSITIVE SYMPTOMS OF SCHIZOPHRENIA AND HAS BEEN SUCCESSFULLY USED IN PATIENTS WHO ARE “NONRESPONDER” TO THE CLASSICAL NEUROLEPTIC DRUGS . DUE TO ITS IMPORTANCE, SEVERAL ANALYTICAL METHODS HAVE BEEN APPLIED FOR THE DETERMINATION OF CLZ IN PHARMACEUTICAL AND BIOLOGICAL SAMPLES [1]. IN COMPARISON, ELECTROANALYTICAL METHODS HAVE ADVANTAGES SUCH AS HIGH SENSITIVITY, INEXPENSIVE EQUIPMENTS, LOW COSTS AND RELATIVE SIMPLICITY. IN THE PRESENT STUDY, THE ELECTROCHEMICAL BEHAVIOR OF CLZ WAS INVESTIGATED USING IN SITU SURFACTANT MODIFIED GRAPHENE OXIDE NANOSHEETS (ISS-GONS) ELECTRODE BY VOLTAMMETRIC TECHNIQUES, AND THE EFFECTS OF SOME EXPERIMENTAL VARIABLES ON THE ELECTRO-OXIDATION OF THIS SUBSTANCE WERE INVESTIGATED [2]. THE GONS MODIFIED ELECTRODE WAS PREPARED IN SITU ON A GRAPHITE ELECTRODE (GE) BY USING CYCLIC VOLTAMMETRY SCANNING BETWEEN 0.0 AND 2.0 V (VS. AG/AGCL) FOR FOUR CYCLES [3]. IN THE NEXT STEP, THE MODIFIED ELECTRODE WAS INSERTED IN ADODECYLTRIMETHYLAMMONIUM BROMIDE SURFACTANT SOLUTION FOR 5 MIN TO IN SITU MODIFICATION OF THE ELECTRODE SURFACE. FINALLY, THE MODIFIED ELECTRODE (ISS-GONS/MGE) WAS SUCCESSFULLY USED FOR THE ELECTROCHEMICAL DETERMINATION OF CLZ UNDER THE OPTIMIZED CONDITIONS BY CYCLIC AND DIFFERENTIAL PULSE VOLTAMMETRY. AT THE OPTIMUM CONDITIONS, THE PEAK CURRENT WAS LINEARLY DEPENDENT ON THE CLZ CONCENTRATION IN THE RANGE OF 0.01 TO 75 MM WITH DETECTION LIMIT OF 5.94 NM. THE PROPOSED ELECTRODE WAS SUCCESSFULLY APPLIED FOR THE DETERMINATION OF CLZ IN HUMAN BLOOD SERUM AND PLASMA SAMPLES.

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APA: Copy

ARVAND, M., & ALIJANI, H.. (2014). IN SITU SURFACTANT MODIFIED GRAPHENE OXIDE NANOSHEETSELECTRODE FOR ELECTROCHEMICAL INVESTIGATION OF CLOZAPINE. IRANIAN BIENNIAL ELECTROCHEMISTRY SEMINAR. SID. https://sid.ir/paper/912500/en

Vancouver: Copy

ARVAND M., ALIJANI H.. IN SITU SURFACTANT MODIFIED GRAPHENE OXIDE NANOSHEETSELECTRODE FOR ELECTROCHEMICAL INVESTIGATION OF CLOZAPINE. 2014. Available from: https://sid.ir/paper/912500/en

IEEE: Copy

M. ARVAND, and H. ALIJANI, “IN SITU SURFACTANT MODIFIED GRAPHENE OXIDE NANOSHEETSELECTRODE FOR ELECTROCHEMICAL INVESTIGATION OF CLOZAPINE,” presented at the IRANIAN BIENNIAL ELECTROCHEMISTRY SEMINAR. 2014, [Online]. Available: https://sid.ir/paper/912500/en

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