Introduction: The present study aimed to investigate the change of air pollutants in 2020 in Qom compared to the same period in 2019 in five scenarios. Materials and Methods: The hourly air quality data was obtained from air quality monitoring stations of Qom Environmental Protection Organization (EPO). The meteorological parameters were obtained from Iranian Meteorological Organization website. The data were analyzed using Excel, SPSS, and WRplot view. Results: In the first month of the COVID-19 crisis, NO2, SO2, and CO decreased by 26. 4, 39, and 0. 2 μ, g/m3 compared to same period in 2019, respectively,however, PM2. 5 and O3 increased by 7. 1 and 2. 3 μ, g/m3, respectively. In Iranian Nowruz holidays, an increase of 2. 9 μ, g/m3 in O3 mean concentration and a decrease of 8. 1, 23. 8, 22. 8, and 0. 2 μ, g/m3 in mean concentration of PM10, NO2, SO2, and CO were experienced. The prevailing wind direction during the 2020 in each scenario was from the west of Qom city. Conclusion: Gaseous pollutants decreased during the crisis, but particulate pollutants increased slightly compared to the same period in 2019. The lockdown may have had the most impact in decreasing pollutants. A slight increase in wind speed from the west could be a factor in increasing particles. This crisis provided an opportunity to assess the role of policies, such as traffic reduction plans or discarding worn-out cars or urban management to improve air quality.