ULTRASOUND-ASSISTED EXTRACTION METHOD WAS APPLIED FOR PHENOLIC COMPOUNDS EXTRACTION FROM JUJUBE BY THE SIMULTANEOUS MAXIMIZATION OF THE YIELD IN THE TOTAL PHENOLICS USING THE RESPONSE SURFACE METHODOLOGY. A BOX-BEHNKEN WAS USED TO INVESTIGATE THE EFFECTS OF FOUR INDEPENDENT VARIABLES, NAMELY TIME (20-50 MIN), TEMPERATURE (20-50OC), SOUND INTENSITY (60-100%) AND SOLVENT COMPOSITION (40-80%) ON THE DEPENDENT VARIABLES (AMOUNT OF TOTAL PHENOLIC CONTENT AND ANTIOXIDANT ACTIVITY). A SECOND-ORDER POLYNOMIAL MODEL WAS USED TO DESCRIBE THE EXPERIMENTAL DATA REGARDING THE TOTAL PHENOLICS. CORRELATION COEFFICIENT (R2) OF THE MODEL FOR TOTAL PHENOLIC CONTENT WAS 0.98.OPTIMAL CONDITIONS FOR TOTAL PHENOLIC CONTENT WERE TEMPERATURE 480C, 72% SOLVENT COMPOSITION, SOUND INTENSITY 96% AND 48 MIN. IN OPTIMAL CONDITIONS, THE TOTAL PHENOLIC CONTENT 15.8 MG GALLIC ACID EQUIVALENT /G DRY MATTER WAS PREDICTED BY THE MODEL. UNDER OPTIMIZED CONDITIONS THE EXPERIMENTAL VALUES AGREED WITH THE VALUES PREDICTED BY MODELS.