CHEMOMETRICS AS A FAST SPREADING FIELD, RECENTLY BEING APPLIED IN NANOTECHNOLOGY. NANOCARRIER SYSTEM HAS BEEN PROPOSED AS A PROMISING ALTERNATIVE TO CONVENTIONAL DRUG DELIVERY SYSTEM. RECENTLY, NANOTECHNOLOGY BASED DRUG DELIVERY SYSTEMS HAVE GAINED VITAL IMPORTANCE AND FEW OF THE PRODUCTS WERE SUCCESSFULLY LAUNCHED IN THE MARKET AND PROVIDE LARGE NUMBER OF ADVANTAGES INCLUDE REDUCE THE NUMBERS OF DOSES AND DOSE FREQUENCY, IMPROVE BIOAVAILABILITY OF POORLY WATER SOLUBLE DRUGS, REDUCE SIDE EFFECTS AND IMPROVE THE THERAPEUTIC EFFICACY. ...

BONE METASTASES ARE COMMON IN PATIENTS WITH MANY TYPES OF CANCER, ESPECIALLY BREAST AND PROSTATE CANCER, TO THESE STRICTLY PALLIATIVE INTERVENTIONS, BISPHOSPHONATES HAVE EMERGED IN RECENT YEARS AS A HIGHLY EFFECTIVE THERAPEUTIC OPTION FOR THE PREVENTION OF SKELETAL COMPLICATIONS SECONDARY TO BONE METASTASES. THE INTERACTION OF DNA WITH FOUR ALIPHATIC CHAIN A-AMINOBISPHOSPHONATE WERE INVESTIGATED IN A TRIS–HYDROGEN CHLORIDE BUFFER (PH 7.4) IN THE PRESENCE AND ABSENCE OF SPECTROSCOPIC PROBES (NEUTRAL RED DYE AND HOECHEST) SPECTROSCOPIC METHODS, ELECTROCHEMICAL TECHNIQUES AND VISCOMETRY. THE SPECTROSCOPIC AND VOLTAMMETRIC STUDIES SHOWED THAT THE GROOVE BINDING MODE OF INTERACTION IS PREDOMINANT IN THE SOLUTION CONTAINING DNA AND A-AMINOBISPHOSPHONATES. FURTHERMORE, THE RESULTS INDICATED THAT THE BINDING STRENGTH OF THE DNA -A-AMINOBISPHOSPHONATE COMPLEXES ARE DEPENDENT ON ALKYL MOIETY PRESENTED IN THE STRUCTURE OF A-AMINOALKYLPHOSPHONIC ACIDS. THE PRINCIPAL COMPONENT ANALYSIS (PCA) AND THEORETICAL QUANTUM MECHANICAL AND MOLECULAR MECHANICS (QM-DFT/B3LYP/6-31+G* AND MMSYBYL) METHODS WERE ALSO APPLIED TO DETERMINE THE NUMBER OF CHEMICAL COMPONENTS PRESENTED IN COMPLEXATION EQUILIBRIUM AND IDENTIFY THE STRUCTURE COMPLEXES OF DNA WITH A-AMINOBISPHOSPHONATES, RESPECTIVELY.

THE PURPOSE OF THIS STUDY, WAS TO EVALUATION OF THE STRUCTURAL AND CHEMICAL CHANGES IN CARBON NANOTUBES DURING THE FUNCTIONALIZATION OF CNT BY SPECTROSCOPIC – CHEMOMETRICS METHOD. A WET CHEMICAL FUNCTIONALIZATION PROCESS OF CARBON NANO TUBES (CNT) IS DONE TO STUDY THE PROCESS OF SULFONATION OF CNT...

CHEMOMETRICS HAS BEEN USED FOR SOME 40 YEARS BUT THERE IS STILL NEED FOR DISSEMINATING THE POTENTIAL BENEFITS TO A WIDER AUDIENCE. CHEMOMETRICS CAN BE CONSIDERED AS AN INNOVATIVE TOOL THAT CAN BE USED BY DIFFERENT CHEMICAL DISCIPLINES TO SOLVE BOTH DESCRIPTIVE IN PREDICTIVE PROBLEMS...

BACKGROUND: MULTIVARIATE ANALYSIS AS A CHEMOMETRIC TOOL HELPS GEOMETRICS FOR SOIL ANALYSIS IN PRODUCING INFORMATIVE RESULT. USING OF MODERN ANALYTICAL INSTRUMENT, CREATING LARGE AMOUNT OF DATA THAT BECAUSE OF SOME PROBLEMS SUCH AS STRONG VARIATION OF THE ELEMENTS CONCENTRATION IN ANALYZED SAMPLES AND MUTUAL INTERACTIONS HARDLY BE USEFUL WITHOUT PREPROCESSING [1]. EXPLORING SOURCES OF PRECIOUS METALS IS ONE OF THE MAIN CONCERNS OF GEOMETRICS. STATISTICAL ANALYSIS PROCEDURES CAN PROVIDE VALUABLE KNOWLEDGE FOR FINDING THE ORIGIN OF SUCH ELEMENTS AND INTERPRETATION OF INITIAL DATA [2].METHOD: IN THIS WORK, THE APPORTIONMENT OF AU IN ROCK SAMPLES BY STUDYING ON A COLLECTED DATA FROM SARILAR, AZARBAYEJAN SHARGHI, IS INVESTIGATED. IN ADDITION, THE DISTRIBUTION OF SOME PARAGENETIC ELEMENTS (CU, PB, ZN, AG, SN, MO, AS, SB, BI) IS DETERMINED.RESULT IN PRESENT STUDY, PRINCIPAL COMPONENT ANALYSIS (PCA) IS APPLIED ON A COLLECTION OF DATA CONSIST OF 130 SAMPLES AND LEVEL OF 10 ELEMENTS FOR ANALYSIS AND CLUSTERING. PCA RESULTS DEMONSTRATE A SPECIAL DISTRIBUTION PATTERN FOR SAMPLES. OBVIOUSLY, SAMPLES DIVIDED UPON THEIR GEOCHEMICAL CHARACTERISTICS AND CAN BE USEFUL IN FINDING PROSPECTING TARGETS SUCH AS AU.CONCLUSION: USING A PCA AS A SUPERVISED CLASSIFICATION METHOD FOR ANALYZING THE DATA SET PROVIDE AN INFORMATIVE RESULT OF A RAW GEOMETRICS DATA BY SUMMARIZING THE INFORMATION FROM A LARGE NUMBER OF COMPONENTS. UNFORTUNATELY, PRINCIPAL COMPONENT ARE OFTEN DIFFICULT TO INTERPRET. SO FOR PREDICTING MINERAL OCCURRENCE POTENTIALS AND IMPROVING ITS INTERPRETABILITY, IT WOULD BE BENEFICIAL TO APPLY OTHER CLASSIFICATION METHODS IN PARALLEL.

INTRODUCTION: GLYCOGEN PHOSPHORYLASE (GP) IS THE ENZYME RESPONSIBLE FOR GLYCOGEN BREAKDOWN TO PRODUCE GLUCOSE AND RELATED METABOLITES FOR ENERGY SUPPLY. DUE TO ITS KEY ROLE OF GP IN MODULATION OF GLYCOGEN METABOLISM, PHARMACOLOGICAL INHIBITION OF GP HAS BEEN REGARDED AS AN EFFECTIVE …

CHEMOMETRICS RESEARCH WAS STARTED IN THE LATE OF 1970 DECADE BY THE COLLABORATIVE WORKS OF TWO CHEMISTS FROM UNITED STATES AND SWEDEN; B.R. KOWALSKI AND S. WOLD, RESPECTIVELY. ABOUT TWO DECADES LATER, CHEMOMETRICS RESEARCH WAS BEGUN IN IRAN...

PETROLEUM INDUSTRY DEMANDS ROBUST POWERFUL ANALYTICAL APPROACHED WHICH COULD SUPPORT THE QUALITY INSPECTION, STRUCTURE INVESTIGATION, FORENSIC ANALYSIS AND EVEN ECONOMIC EVALUATION [1].PETROLEUM SAMPLES ARE DIFFERENT IN CHEMICAL COMPOSITION, BASED ON THEIR ORIGINS, TRANSFORMATION, UNEXPECTED EVENTS LIKE ADULTERATION, ETC. DIFFERENCE IN CHEMICAL COMPOSITION AFFECTS THEIR REFINING PROCEDURE, QUALITY PARAMETERS AND FINALLY MARKETING [2]. CONSIDERING THE USEFUL CAPABILITY OF INFRARED (IR) SPECTROSCOPY AS A RAPID, ECONOMIC AND NON-DESTRUCTIVE METHOD FOR IDENTIFICATION OF CHEMICAL SAMPLES, A PRACTICAL APPROACH WAS INVESTIGATED FOR ANALYSIS OF PETROLEUM SAMPLES BASED ON THEIR INFORMATIVE SPECTRAL FEATURES IN MID-IR REGION. IN THIS WORK, TOTALLY 85 SAMPLES FROM 3 DIFFERENT SOURCES: 2 PETROLEUM RESERVOIRS AND ONE PRODUCTION FOR EXPORT WERE COMPARED IN BINARY MODELS, BY FOURIER TRANSFORM INFRARED (FTIR) SPECTROSCOPY AND LEAST SQUARE SUPPORT VECTOR MACHINES (LS-SVM). VARIABLE SELECTION BASED ON GENETIC ALGORITHM (GA) WAS UTILIZED AS PREPROCESSING METHOD TO IMPROVE THE RELIABILITY OF PROPOSED METHOD. RESULTS OF BINARY COMPARISONS WERE OBTAINED FROM CONDUCTED CLASSIFICATIONS. MORE TEST ACCURACY VALUES STEAMS FROM MORE DIFFERENCES AND REVERSELY LESS TEST ACCURACY VALUES REFERS TO MORE SIMILARITIES BETWEEN DIFFERENT FIELDS. THE ACCURACY VALUES FOR BINARY CLASSIFICATION WERE BETWEEN 91.3-97.1 %