The inability to conceive children is experienced as a stressful situation by couples all around the world and infertility is a devastating experience, especially for women. Evidences indicate important QOL impairments in infertile women. Among men, it does not appear to be intense. Also little attention has been paid to the psychological status of infertile men from developing countries who have been traditionally stigmatized as feeble and ineffective. The consequences of infertility are manifold and can include societal repercussions and personal suffering. Health professionals need to consider all aspects of holistic care when caring for couple with fertility problems, Cultural; psychological, religious and spiritual dimensions of infertility have received little attention in our society. Advances in assisted reproductive technologies, such as IVF, can offer hope to many couples where treatment is available, although barriers exist in terms of medical coverage and affordability. The medicalization of infertility has unwillingly led to a disregard for the emotional responses that couples experience, which include distress, loss of control, stigmatization, and a disruption in the developmental trajectory of adulthood. Evidence is emerging of an association between stress of fertility treatment and patient drop-out and pregnancy rates.Fortunately, psychological interventions have been shown to have beneficial effects for infertility patients.