Background: Parkinson disease is one of the most prevalent degenerative nervous system diseases. Some recent studies show the possible effects of uric acid on this disorder. The aim of this study was to evaluate serum level of uric acid in patients with Parkinson disease.Material & Methods: Serum uric acid were determined in 50 patients with Parkinson's disease and compared with 50 healthy persons, which were matched with age and sex. Data were analyzed with software SPSS-16 and statistical descriptive methods (mean-percentage, SD) and t-test.Results: In this study, 26 men (52%) and 24 women (48%) were evaluated. The mean serum uric acid in patients was 4.79±1.21 and in the control group was 5.85 ±1.41. This difference was statistically significant (p£0.001). Also, the mean serum uric acid in both men (4.87±1.20) and women (4.7±1.23) in patients group was statistically lower than both men (5.42±1.25) and women (5.91±1.62) in control group (p£0.001).Conclusion: The findings of this study show that low serum uric acid increase the risk of Parkinson's disease

As a chronic, immune-mediated skin disorder, psoriasis affects approximately 2-4% of people 1. Pustular, erythrodermic, guttate psoriasis, and psoriasis vulgaris comprise frequent forms of the disease, while psoriatic arthritis has been described as a rare form. Patients might suffer from itchy and/or painful lesions and although its exact pathogenesis is not well established, abnormal differentiation and hyperproliferation of keratinocytes, increased epidermal cell turnover, and infiltration of inflammatory cells have been suggested as its characteristics, with inflammatory cytokines also having been implicated to be involved in psoriatic lesions 2. Greater risks of cardiovascular disease (CVD) 3, metabolic syndrome (MetS) 4, dyslipidemia, type 2 diabetes mellitus (T2DM), obesity, and hypertension are associated with psoriasis 5. . . .

Background: Acute heart failure (AHF) is defined as the new onset or recurrence of gradual or rapidly worsening signs and symptoms of heart failure, requiring urgent or emergent therapy.Objectives: This study attempts to assess the association of liver function tests (LFT) and uric acid level with in hospital outcome and echocardiography parameters, in patients with acute decompensated heart failure.Patients and Methods: A total of 100 patients (aged 16-90 years, 60% men) admitted with AHF were enrolled. LFTs and uric acid levels were assessed on first day and before discharge, and patients were followed for 3 months.Results: In-hospital outcomes were considered. Mean Left Ventricular Ejection Fraction (LVEF) was 35% (20-45%). Mean uric acid level was 8.4 mg/dL, significantly higher than chronic HF and normal groups (P<0.02). Elevated liver enzymes were seen in 52% patients, mostly (87%) in transaminases. Liver enzymes were decreased in 85% patients before discharge. LFT and uric acid levels were inversely and significantly correlated with LVEF on echocardiography (P=0.02), but not with diastolic parameters. Although there was no significant correlation between uric acid level and in-hospital mortality, risk of intubation and rehospitalization in 3 months, enzyme levels increased in these groups. Increased aspartate transaminase (AST level) was associated with inotrope infusion in AHF patients (42 vs. 82 mg/dL, P=0.03).Conclusions: Abnormal transaminases and uric acid levels are seen in AHF patients. Increased AST levels may be a predictor of the need for inotrope during hospital course in these patients.