Context: social relations have been found to affect different aspects of people’s life. This article is a systematic review of attempts to consider the social support as a major determinant of health during life span.Evidence Acquisition: For our research we retrieved data from the J Store, Springer, Wiley Online Library, Elsevier, Science Direct, PubMed database as well-known sources of scientific studies. The study comprised all studies considering social ties and relationships and health outcomes of both genders in different aspects of medical sociology and social epidemiology, with particular emphasis on comprehensive studies to identify the implications of and the effect of social support on women’s health.Results: The results obtained from this review are presented in three main sections. These include perceived versus received social support, main effect versus buffering effect of social support, and finally the consideration of women’s health. Overall, empirical studies confirm the importance of social relationship to health and longevity and its different implications in women’s health.Conclusions: To be healthier and more usefully active in the society, women need to have different kinds of support from social relationships. Women are required to be better informed about the significance of enjoying positive social relationships which provide potential health benefits, by social support, from both relatives and other people.