Background: Tobacco use has a serious impact on health and socioeconomics situation of general population. Majority of people has started it in teen age and the most of them will probably be addicted. Meanwhile, school-based interventions can play an essential role in prevention or delay tobacco consumption, but there is no structured program for such interventions in Iran. Current study has been designed to provide a national evidence based guideline for school- based interventions.Methods: We conducted wide search main databases and websites considering Pub Med, NICE, GIN, NGC, SIGN and other related websites for defined keywords. Related guidelines were selected and appraised by two independent experts using AGREE-2 tool. The highest record was translated to Persian and discussed in panel of guideline for adopting with Iranian culture and condition. The preview was sent to experts and stockholders for final edition and then was published for pilot application.Findings: Eleven related guidelines retrieved in which only two were about school-based interventions recommended. The main recommendations for prevention of smoking was as following: Pay attention and take the organizational wide approaches in schools, plan and do interventions by adults, plan and do interventions by peers, train, retrain and develop, and pay attention and take the coordinated approach.Conclusion: Iranian school based guideline is a well adopted tool to prevent tobacco consumption in teen ages.