Today, increasing the quality and quantity of agriculture production is a need more and more. In recent several decades, the only practical solution to meet the needs of decreased quality and quantity of production is increase average yield of farm and the decrease and avoidance of 37% loss resulted of pests, diseases, and weeds. Although using the pesticide is useful in short time, has undesirable effect including ecocide side effect, the toxin remained in productions and their threat on bio-community such as human being. The proponents of integrated pest management is using the integration of pest control population - not only resorting of chemical pesticides - including agricultural, physical, chemical, biological method for meet to economic needs and bio-community protection in the threshold economic time. on the other hand, the proponents of biotechnology is recognizing and using the options contains the strange potential method to fight against the pests and diseases including producing the plants that are resistance against the pest and reinforcing the pest biologic control. Biotechnology lets us manage the pests well under integrated pest management chart.This article review the capability of the integrated pests management and biotechnology to control pests by using the methods compatible with environment and biosafety.