Gas separation by a membrane is performed without phase changing, leading to cost reduction. This study investigates the process of gas separation in the case of polyacrylonitrile (PAN) and polysulfone (PSF) blend membranes. The ratios of polymers to mixed matrix membranes include 100% PAN, 100% PSF, (95% PAN{5% PSF), (90% PAN{10% PSF), (85% PAN{15% PSF). The best combination of membrane mixtures was determined. Then, iron oxide nanoparticles with di erent weight percentages were placed on the membrane. The impact of adding di erent amounts of iron oxide nanoparticles to the membrane on gas separation was examined. By adding iron oxide nanoparticles to the membrane by 10% weight and measuring the value of permeability, it was observed that the permeability of this membrane for carbon dioxide, oxygen, nitrogen, and methane gases increased by 117%, 137%, 95%, and 53% compared to membranes without iron oxide nanoparticles. Based on the ndings, it was revealed that the optimal value of adding iron oxide to improve the membrane properties was 10% by weight.