THERAPEUTIC DRUG MONITORING (TDM) PLAYS AN INCREASINGLY IMPORTANT ROLE IN THE CLINICAL USE OF TRICYCLIC ANTIDEPRESSANTS SUCH AS PERPHENAZINE (PPZ) AND OTHER PSYCHIATRIC DRUGS [1]. TO THE BEST OF OUR KNOWLEDGE, TECHNIQUES AVAILABLE FOR MONITORING PERPHENAZINE AND OTHER NEUROLEPTICS ARE GAS CHROMATOGRAPHY (GC) AND HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC). ...

IN THE PRESENT STUDY A METHOD HAS BEEN INTRODUCED FOR THE SYNTHESIS OF magnetic NANOPARTICLES. BY THIS METHOD, FE3O4 NANOPARTICLES ARE PREPARED USING CO-PRECIPITATION METHOD [1]. THEN, magnetic IONIC imprinted polymers (MIIPS) AND magnetic NON imprinted polymers. ...

HISTAMINE IS THE CAUSATIVE AGENT OF SCOMBROID POISONING, A FOOD-BORNE CHEMICAL HAZARD [1]. TUNA CONTAINS LARGE AMOUNT OF FREE HISTIDINE, AND THE ENZYME, HISTIDINE DECARBOXYLASE, EFFICIENTLY CONVERTS HISTIDINE TO HISTAMINE [2]. ...

UREA IS ONE OF THE MOST IMPORTANT MOLECULES IN THE BODY THAT REGULATE THE EXACT AMOUNT IS NONTOXIC. BY KIDNEY, BLOOD UREA LEVELS ARE CAREFULLY REGULATED. BLOOD UREA IS NOT REGULATED IN RENAL COMPLICATIONS. TODAY IT CAN BE DONE IN DIFFERENT WAYS, EACH OF WHICH HAS ADVANTAGES AND DISADVANTAGES. IN THIS REGARD, magnetic molecularLY imprinted polymers (MMIPS) CAN BE USED FOR THE SELECTIVE DETERMINATION AND SEPARATION OF UREA. BY APPLYING THE IMPROVED CO-PRECIPITATION METHOD, magnetic FE3O4 PARTICLES WERE EASILY PREPARED, FOLLOWED BY MODIFICATION WITH TEOS AND FUNCTIONALIZATION WITH VINYL. IN THIS WORK USING FUNCTIONALIZED FE3O4 PARTICLES AS THE magnetic CORES, UREA AS THE TEMPLATE, AND METACRYLIC ACID (MAA) AS THE FUNCTIONAL MONOMER, MMIPS WERE SYNTHESIZED AND POLYMERIZATION AT 60 C FOR 24 H. OPTIMIZED IMPRINTING FACTOR WAS CALCULATED 2.2 MMOL/GR, AND THE RESULT OF THE REAL SAMPLES ANALYSIS IN THE CASE OF URIN AND PLASMA, INDICATING THE % RECOVERY IS ABOVE 95%. magnetic NON-molecularLY imprinted polymers (MNIPS) WERE ALSO PREPARED WITH THE SAME SYNTHESIS PROCEDURE AS MMIPS ONLY WITHOUT THE PRESENCE OF UREA. magnetic PARTICLES WERE CHARACTERIZED BY TEM, SEM, FT-IR, VSM AND XRD ANALYSIS. WE SHOW THAT THE PREPARED MMIPS WITH MANY ADVANTAGES POSSESS THE VALUE OF PRACTICAL APPLICATION.

THIS PAPER DESCRIBES NOVEL SYNTHETIC CONDITIONS OF PRECIPITATION POLYMERIZATION TO OBTAIN UNIFORMLY SIZED molecularLY imprinted NANO-SPHERES OF HYDANTOINS FOR APPLICATION IN DESIGN OF THE NEW DRUG DELIVERY SYSTEMS. IN ADDITION, THE STRUCTURE, MORPHOLOGY, THERMAL STABILITY, THERMAL BEHAVIOR AND BINDING PROPERTIES OF molecularLY imprinted polymers (MIPS) WERE STUDIED. THE imprinted NANOSPHERES SHOWED EXCELLENT BINDING PROPERTIES AND HAD 10-15% HIGHER TEMPLATE BINDING COMPARED TO ITS BLANK POLYMER. polymers WITH HIGH THERMAL STABILITY WERE OBTAINED AND UNLEACHED POLYMER PARTICLES SHOWED HIGHER THERMAL STABILITY THAN LEACHED MIP PARTICLES.

molecularLY imprinted polymers (MIPS) ARE PREPARED BY MIXING OF TEMPLATE MOLECULE WITH FUNCTIONAL MONOMERS, CROSS-LINKER AND A RADICAL INITIATOR IN A SOLVENT. AFTER POLYMERIZATION AND EXTRACTED OUT OF THE TEMPLATE MOLECULE, THE RESULTING imprinted POLYMER POSSESSING A PERMANENT MEMORY FOR THE IMPRINT SPECIES ARE FORMED, ENABLING THE RESULTANT POLYMER SELECTIVELY TO REBIND THE IMPRINT MOLECULE FROM A MIXTURE OF CLOSELY RELATED COMPOUNDS. THE TEMPLATE IS CENTRAL IMPORTANCE AND IT DIRECTS ORGANIZATION OF THE FUNCTIONAL GROUPS PENDENT TO THE FUNCTIONAL MONOMERS. THE KIND OF MONOMER, CROSS-LINKER AND THE RATIO OF THEM IS UNIQUE FOR EACH REACTION. MIPS ARE USED AS A SORBENT IN SENSORS, DRUG DELIVERY, EXTRACTION OF BIOACTIVE COMPONENT FROM HERBAL PLANTS, SEPARATION OF TOXIC MATERIALS LIKE HERBICIDES OR HEAVY METAL IONS CD2+, HG2+ AND PB2+ IN WASTEWATER TREATMENT. IN THIS RESEARCH THE MIPS WERE SYNTHESIZED BY USING OF QUERCETIN WHICH IS A BIOACTIVE COMPOUND WITH ANTIVIRAL AND ANTITUMOR PROPERTIES AS A CASE STUDY TEMPLATE. THE NANOPOROUS MIPS WERE EVALUATED VIA BET ANALYSIS. THE SPECIFIC SURFACE AREA OF MIPS AND NIPS WERE MEASURED 167.899 AND 93.545 M2/G, RESPECTIVELY. THE MIPS ACHIEVED A BINDING CAPACITY OF 392.08 MG/GR POLYMER IN. THE AMOUNT OF THE EXTRACTED COMPOUNDS WAS CONFIRMED VIA MEASURING THE ABSORBANCE AT 254 NM BY AN UV-VIS SPECTROPHOTOMETER. THE RELATED IMAGING BY ATOMIC FORCED MICROSCOPY (AFM) INDICATED THE SIZE OF MIPS IS LESS THAN 20 NM. SEPARATION OF TOXIC MATERIALS IN WASTEWATER TREATMENT AND EXTRACTION OF THE BIOACTIVE COMPOUND FROM SOLUTIONS ARE CONSIDERABLE BY MIPS TECHNOLOGY.