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مرکز اطلاعات علمی SID1
مرکز اطلاعات علمی SID
اسکوپوس
مرکز اطلاعات علمی SID
ریسرچگیت
strs
عنوان: 
نویسندگان: 

TABY R. | ISSA J.P.

اطلاعات دوره: 
  • سال: 

    2010
  • دوره: 

    60
  • شماره: 

    6
  • صفحات: 

    376-392
تعامل: 
  • استنادات: 

    315
  • بازدید: 

    7122
  • دانلود: 

    9195
کلیدواژه: 
چکیده: 

آمار یکساله:  

بازدید 7122

دانلود 9195 استناد 315 مرجع 0
نویسندگان: 

QIU J.

نشریه: 

NATURE

اطلاعات دوره: 
  • سال: 

    2006
  • دوره: 

    441
  • شماره: 

    7090
  • صفحات: 

    143-145
تعامل: 
  • استنادات: 

    315
  • بازدید: 

    8386
  • دانلود: 

    9195
کلیدواژه: 
چکیده: 

آمار یکساله:  

بازدید 8386

دانلود 9195 استناد 315 مرجع 0
عنوان: 
نویسندگان: 

اطلاعات دوره: 
  • سال: 

    2018
  • دوره: 

    667
  • شماره: 

    -
  • صفحات: 

    40-46
تعامل: 
  • استنادات: 

    315
  • بازدید: 

    3632
  • دانلود: 

    9195
کلیدواژه: 
چکیده: 

آمار یکساله:  

بازدید 3632

دانلود 9195 استناد 315 مرجع 0
گارگاه ها آموزشی
اطلاعات دوره: 
  • سال: 

    2016
  • دوره: 

    0
  • شماره: 

    11
تعامل: 
  • بازدید: 

    1050
  • دانلود: 

    0
کلیدواژه: 
چکیده: 

STABLE MOLECULAR CHANGES DURING CELL DIVISION WITHOUT CHANGE THE SEQUENCE OF DNA MOLECULES IS KNOWN AS EPIGENETIC. MOLECULAR MECHANISMS INVOLVED IN THIS PROCESS, INCLUDING HISTONE MODIFICATIONS, METHYLATION OF DNA, PROTEIN COMPLEX AND RNA ANTISENSE….

آمار یکساله:  

بازدید 1050

دانلود 0
نویسندگان: 

BIRD A.

نشریه: 

NATURE

اطلاعات دوره: 
  • سال: 

    2007
  • دوره: 

    447
  • شماره: 

    7143
  • صفحات: 

    396-398
تعامل: 
  • استنادات: 

    315
  • بازدید: 

    8571
  • دانلود: 

    9195
کلیدواژه: 
چکیده: 

آمار یکساله:  

بازدید 8571

دانلود 9195 استناد 315 مرجع 0
نویسندگان: 

JIANG Y.H. | BRESSLER J.

اطلاعات دوره: 
  • سال: 

    2004
  • دوره: 

    5
  • شماره: 

    -
  • صفحات: 

    479-510
تعامل: 
  • استنادات: 

    315
  • بازدید: 

    4450
  • دانلود: 

    9195
کلیدواژه: 
چکیده: 

آمار یکساله:  

بازدید 4450

دانلود 9195 استناد 315 مرجع 0
strs
نویسندگان: 

KHORSANDI KHATEREH | HOSSEINZADEH REZA

اطلاعات دوره: 
  • سال: 

    2018
  • دوره: 

    9
  • شماره: 

    SUPPL A (9TH WORLD CONGRESS OF SOLA)
  • صفحات: 

    31-31
تعامل: 
  • استنادات: 

    0
  • بازدید: 

    18700
  • دانلود: 

    9450
کلیدواژه: 
چکیده: 

epigenetics is the study of heritable alterations in gene expression that are not accompanied by the corresponding change in DNA sequence. Three important epigenetic processes regulate gene expression at the level of chromatin including nucleosomal remodeling, DNA methylation, and histone covalent modifications. Chromatin is a highly dynamic structure composed of DNA and protein (histone and non-histone proteins). Histone amino-terminal regions can undergo modification by acetylation, methylation, phosphorylation, ubiquitylation, sumoylation and ADP ribosylation. The enzymes histone acetyl transferase (HAT) and histone deacetylase (HDAC) control the acetylation level of histones and thereby alter gene expression.Many cancers display molecular alterations that change the balance between HAT and HDAC activity. HDACs exert a pro‑oncogenic effect by silencing genes involved in differentiation, apoptosis and cell cycle arrest. Therefore, the inhibition of HDACs is a target for the development of novel anticancer therapy. Histone deacetylase inhibitors (HDACIs) show anticancer activity by promoting acetylation of histones. The effect of HDACI is different such as cell cycle arrest, inhibit DNA repair, and induce apoptosis.Photodynamic therapy is a form of radiation therapy that is composed of three important parts: a photosensitizer, molecular oxygen and light at a specified wavelength for producing reactive oxygen species (ROS), particularly singlet oxygen in tumor cells. The tumor cells would be destroyed by apoptosis and/or necrosis induced by ROS, achieving the goal of local treatment with minimum invasion.Although the role of photodynamic therapy on the epigenetic process such as DNA methylation and histone deacetylase is unknown, recently some studies demonstrated that the light could control epigenetic regulator such as HDAC enzymes. Eventually, a combination of photodynamic therapy with epigenetic may be a novel approach for a more tumor-selective treatment.

آمار یکساله:  

بازدید 18700

دانلود 9450 استناد 0 مرجع 0
نویسنده: 

MINOOEE SONIA

اطلاعات دوره: 
  • سال: 

    2014
  • دوره: 

    0
  • شماره: 

    6
تعامل: 
  • بازدید: 

    1365
  • دانلود: 

    0
چکیده: 

INTRODUCTION: epigenetics IS THE STUDY OF HERITABLE CHANGES IN GENE EXPRESSION OR PHENOTYPE OCCURRING WITHOUT CHANGES IN DNA SEQUENCE. WHILE NEW EPIGENETIC MECHANISMS ARE BEING UNCOVERED, THE BEST CHARACTERIZED ARE DNA METHYLATION, CHANGES IN HISTONE PROTEINS AROUND WHICH DNA IS PACKAGED, AND EXPRESSION OF NON-CODING RNAS. THE PRIMORDIAL GERM CELLS, EMBRYO, AND FETUS ARE HIGHLY SUSCEPTIBLE TO EPIGENETIC DYSREGULATION BY ENVIRONMENTAL CHEMICALS, WHICH CAN THEREBY EXERT MULTIPLE ADVERSE EFFECTS. ...

آمار یکساله:  

بازدید 1365

دانلود 0
نویسنده: 

HERAVI MOUSSAVI ALIREZA

اطلاعات دوره: 
  • سال: 

    2016
  • دوره: 

    0
  • شماره: 

    3
تعامل: 
  • بازدید: 

    1260
  • دانلود: 

    0
کلیدواژه: 
چکیده: 

COLORECTAL CANCER (CRC) IS THE THIRD MOST COMMON CANCER IN THE WORLD. THIS DISEASE IS THE FORTH MOST COMMON CANCER IN IRANIAN MEN AND THE SECOND AMONG WOMEN. CRC HAS BECOME ONE OF THE DEADLIEST AND ALSO ONE OF THE MOST AVOIDABLE CANCERS. COLORECTAL CANCER DEATH RATES HAVE BEEN DECLINED IN DEVELOPED COUNTRIES PROBABLY DUE TO INCREASED USE OF AVAILABLE SCREENING TESTS AS WELL AS ENCOURAGING A HEALTHFUL DIET AND EXERCISE...

آمار یکساله:  

بازدید 1260

دانلود 0
نشریه: 

JOURNAL OF epigenetics

اطلاعات دوره: 
  • سال: 

    2019
  • دوره: 

    1
  • شماره: 

    1
  • صفحات: 

    24-34
تعامل: 
  • استنادات: 

    0
  • بازدید: 

    8817
  • دانلود: 

    7752
چکیده: 

Plant epigenetic has become one of the key research topics not only as the subject of basic research but also as a new source of useful traits for plant breeding. Epigenetic regulation is necessary for the production of differentiated cells throughout plant development, as well as maintaining the stability and integrity of the gene expression profiles. Although epigenetic processes are essential for natural growth, they can become misdirected led to abnormal phenotypes and diseases. epigenetics is the study of heritable phenotype changes that do not involve alterations in the DNA sequence. The microstructure (not code) of DNA itself or the associated chromatin proteins may be modified, causing activation or silencing. This mechanism enables differentiated cells in a multicellular organism to express only the genes which are necessary for their own activity. In this review, our goal is to introduce epigenetics and its different applications in plants, especially in the production of transgenic plants, plants tolerate to biotic and abiotic stresses and understanding the mechanisms of gene silencing. Also, in this review, we have referred to the role of transposons in epigenetic, epigenetic engineering methods, epigenetic fingerprinting and ultimately methods for epigenetic data analysis and related databases.

آمار یکساله:  

بازدید 8817

دانلود 7752 استناد 0 مرجع 0
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