Faced with various challenges and social issues and the lack of macro-planning in countries, it hinders the possibility of continuing the natural process of business growth and development in different societies. The purpose of this research is to determine the impact of social entrepreneurship on business sustainability through the mediating role of dynamic capabilities. The statistical population of this research was the entrepreneurs participating in the Qazvin Entrepreneurs Festival, 384 people were selected using the available method. The current research is descriptive-survey in terms of practical purpose and method. The research tool was Cho et al. 's (2022) questionnaire. The validity of the questionnaire was confirmed by 5 experts and the reliability of the whole questionnaire was 0. 86. Hypothesis testing was done with structural equation modeling method and in Smart Pls and SPSS software. The findings showed that the variables of strategic orientation, altruism and practicality are considered as components of social entrepreneurship. Therefore, by relying on the three components of altruism, strategic orientation and practicality, it is possible to improve dynamic capabilities, and in this way, the sustainability of businesses even in the limits of altruism or practicality, assuming a strategic orientation to find market-friendly solutions with a critical mindset, innovative and socially active promoted. The relationship between the industry and the university and the interaction of policy makers and social entrepreneurs together can take advantage of opportunities in environmental, economic and social dimensions so that they can create prosperity for the society.