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مرکز اطلاعات علمی SID1
مرکز اطلاعات علمی SID
اسکوپوس
مرکز اطلاعات علمی SID
ریسرچگیت
strs
همکاران: 

سارا-سنمار

اطلاعات : 
  • تاریخ پایان: 

    1386
تعامل: 
  • بازدید: 

    185
کلیدواژه: 
چکیده: 

Glucose-6-phosphate dehydrogenates (G6PD) deficiency is the most common defects of red blood cells among Iranian and Mediterranean people. hypothyroidism is defined as thyroid hormone deficiency starting from the time of birth. Thyroid hormones influence the activity of lipogenic enzymes such as glucose-6-phosphate dehydrogenase and malic enzyme. This study aimed to determine the rate of hypothyroidism in patients with G6PD deficiency. After 120 days, the newborns that administered drug and diet for hypothyroidism were checked for TSH and G6PD enzyme. 2287 out of 23260 screened babies were afflicted with favism (512 females and 1775 males). 42 cases were hypothyroid among who 35 had G6PD deficiency. However, after 120 days of treatment with Levothyroxine, 23(85%) patients of them had normal levels of G6PD.It shows that their deficiency had no genetic origin. Base on these findings of this study, the newborns with G6PD deficiency should be checked for thyroid hormones. Moreover, in the hypothyroid patients, checking the level of G6PD is recommended.

آمار یکساله:  

بازدید 185

اطلاعات دوره: 
  • سال: 

    2017
  • دوره: 

    31
  • شماره: 

    1
  • صفحات: 

    0-0
تعامل: 
  • استنادات: 

    0
  • بازدید: 

    17866
  • دانلود: 

    9587
چکیده: 

Background: congenital hypothyroidism (CH), as one of the most common congenital endocrine disorders, may be significantly associated with congenital malformations. This study investigates urogenital abnormalities in children with primary CH (PCH). Methods: This case-control study was conducted on 200 children aged three months to 1 year, referred to Amir-Kabir Hospital, Arak, Iran. One hundred children with PCH, as the case group, and 100 healthy children, as the control group, were selected using convenient sampling. For all children, demographic data checklists were filled, and physical examination, abdomen and pelvic ultrasound and other diagnostic measures (if necessary) were performed to evaluate the congenital urogenital abnormalities including anomalies of the penis and urethra, and disorders and anomalies of the scrotal contents. Results: Among 92 (100%) urogenital anomalies diagnosed, highest frequencies with 37 (40. 2%), 26(28. 2%) and 9 (9. 7%) cases including hypospadias, Cryptorchidism, and hydrocele, respectively. The frequency of urogenital abnormalities among 32 children with PCH, with 52 cases (56. 5%) was significantly higher than the frequency of abnormalities among the 21 children in the control group, with 40 cases (43. 4%). (OR=2. 04; 95%CI: 1. 1-3. 6; p=0. 014). Conclusion: Our study demonstrated that PCH is significantly associated with the congenital urogenital abnormalities. However, due to the lack of evidence in this area, further studies are recommended to determine the necessity of conducting screening programs for abnormalities of the urogenital system in children with CH at birth.

آمار یکساله:  

بازدید 17866

دانلود 9587 استناد 0 مرجع 0
اطلاعات دوره: 
  • سال: 

    2021
  • دوره: 

    24
  • شماره: 

    8
  • صفحات: 

    636-642
تعامل: 
  • استنادات: 

    0
  • بازدید: 

    7528
  • دانلود: 

    6227
چکیده: 

Background: This study was designed and conducted to investigate the spatial distribution of permanent and temporary congenital hyperthyroidism (PCH and TCH) in Isfahan. Methods: This study was conducted on neonates who were born from March 21, 2006 to March 20, 2011 and had undergone the congenital hypothyroidism (CH) screening program in counties affiliated to the Isfahan University of Medical Sciences. CH was diagnosed in 958 patients who treated with levothyroxine. The incidence rates of permanent and temporary congenital hypothyroidism in Isfahan province were calculated and their distribution was shown on the map. The space maps were drawn using the ArcGIS software version 9. 3. Results: Based on the data obtained from the screening program, the average incidence of congenital hypothyroidism in the province during the period of 2006– 2011 was 2. 40 infants per 1000 live births (including both PCH and TCH). The most common occurrence was in Ardestan County (10: 1000) and the lowest overall incidence was observed in the Fereydounshahr county (1. 39: 1000). The incidence of PCH in the counties of Ardestan and Golpayegan had the highest rate in all years of study; and the greatest number of TCH cases in the five years were observed in Nain, Natanz, Khansar and Chadegan counties. Conclusion: Adding the time dimension and performing spatial-temporal analysis is suggested because of the following items: high prevalence of CH in Isfahan province, the important role of this disease in mental retardation and neuropsychiatric disorder, the necessity of conducting future medical researches to find possible factors of CH etiology in Isfahan province, as well as necessity of performing spatial analysis with advanced statistical methods.

آمار یکساله:  

بازدید 7528

دانلود 6227 استناد 0 مرجع 0
گارگاه ها آموزشی
نویسندگان: 

BUYUKGEBIZ A.

اطلاعات دوره: 
  • سال: 

    2013
  • دوره: 

    -
  • شماره: 

    SUPPL 1
  • صفحات: 

    8-12
تعامل: 
  • استنادات: 

    315
  • بازدید: 

    4262
  • دانلود: 

    9195
کلیدواژه: 
چکیده: 

آمار یکساله:  

بازدید 4262

دانلود 9195 استناد 315 مرجع 0
اطلاعات دوره: 
  • سال: 

    2018
  • دوره: 

    9
  • شماره: 

    2
  • صفحات: 

    66-70
تعامل: 
  • استنادات: 

    0
  • بازدید: 

    9728
  • دانلود: 

    8138
چکیده: 

Background: congenital hypothyroidism (CH) is a prevalent disorder, which is associated with several other congenital anomalies, especially cardiac diseases. The present study aimed to determine the prevalence of congenital heart disease (CHD) in the neonates with CH. Methods: This cross-sectional study was conducted on two groups of 79 subjects to compare the type and frequency of congenital cardiac anomalies between the neonates with the confirmed diagnosis of CH (TSH≥ 10 mlU/ml) and healthy infants. The study was performed in Kowsar Clinic affiliated to Arak University of Medical Sciences, Iran. Level of thyroid-stimulating hormone (TSH) was measured within days 3-7 of birth using the samples collected from the soles of the neonates. In addition, all the subjects were evaluated for the presence of CHD using echocardiography before day 30 of life. Results: In total, 79 neonates were enrolled in the study. The case group consisted of 34 females (43. 04%) and 45 males (53. 96%), and the control group consisted of 43 females (54. 43%) and 36 males (45. 57%). The groups were matched in terms of age and gender. Cardiac involvement was only detected in the case group (CH infants) with the prevalence of 22. 7%. Among the non-cyanotic malformations observed in the case group, one infant had ventricular septal defect (1. 3%), eight infants had atrial septal defect (10. 1%), three infants had patent ductus arteriosus (3. 8%), three neonates had endocardial cushion defect (3. 8%), two neonates had pulmonary stenosis (2. 5%), and one infant had dilated cardiomyopathy (1. 3%). Moreover, six neonates were diagnosed with Down syndrome. All the infants with endocardial cushion defect (n=3) had Down syndrome, and no significant association was observed between TSH and thyroxine (T4) in the presence of CHD. Conclusion: According to the results, the high prevalence of cardiac malformations in the neonates with CH necessitated cardiac examinations using echocardiography.

آمار یکساله:  

بازدید 9728

دانلود 8138 استناد 0 مرجع 0
نویسندگان: 

نیلی سیران | قطبی ناهید

نشریه: 

پایش

اطلاعات دوره: 
  • سال: 

    1389
  • دوره: 

    10
  • شماره: 

    1
  • صفحات: 

    15-20
تعامل: 
  • استنادات: 

    1
  • بازدید: 

    476
  • دانلود: 

    101
چکیده: 

کم کاری مادرزادی تیروئید یکی از علل مهم عقب ماندگی ذهنی در نوزادان است که در صورت تشخیص و درمان به موقع عواقب آن قابل پیشگیری است.در صورت وجود کم کاری تیروئید در جنین، اختلالاتی در ارگان های مهم از جمله سیستم عصبی مرکزی و اسکلتی ایجاد می شود. غربالگری هیپوتیروئیدی نوزادان یکی از برنامه های طب پیشگیری است.این بررسی آنالیز داده های برنامه غربالگری مادرزادی تیروئید در استان کردستان به مدت 29 ماه از ابتدای بهمن 84 تا پایان خرداد 87 است. داده ها هرسه ماه یک بار از کلیه مراکز نمونه گیری به سطوح بالاتر ارسال شده و در نهایت آنالیز صورت گرفت.آنالیز داده های 29 ماه بررسی نشان می دهد که از 50539 نفر غربالگری شده بر اساس نمونه تهیه شده، 24806 نفر دختر (49.1 درصد) و 25733 پسر (50.9 درصد) بوده اند. 49576 نوزاد (98 درصد) دارای TSH زیر 5mu/L بوده اند و 777 نفر (1.5 درصد) دارای 5<TSH<9.9mu/L (موارد مشکوک) 175 نفر (0.5 درصد) نیز دارای TSH>10mu/L بوده اند. تا پایان خرداد سال 87، 122 بیمار شناسایی شده اند که از این تعداد 118 نفر (97 درصد) قبل از 28 روزگی و 4 نفر (3 درصد) در سن بیش از 28 روزگی تحت درمان قرار گرفته اند. ارزش اخباری مثبت تست غربالگری مورد استفاده 13.3 است. تاکنون میزان بروزی معادل 1 مورد در 414 تولد زنده در استان کردستان بدست آمده است. با توجه به نتایج بدست آمده می توان نتیجه گرفت میزان کم کاری مادرزادی تیروئید در استان کردستان بالا است.

آمار یکساله:  

بازدید 476

دانلود 101 استناد 1 مرجع 7
strs
نویسندگان: 

BUYUKGEBIZ A.

اطلاعات دوره: 
  • سال: 

    2004
  • دوره: 

    2
  • شماره: 

    1
  • صفحات: 

    185-190
تعامل: 
  • استنادات: 

    315
  • بازدید: 

    4933
  • دانلود: 

    9195
کلیدواژه: 
چکیده: 

آمار یکساله:  

بازدید 4933

دانلود 9195 استناد 315 مرجع 0
نشریه: 

ACTA MEDICA IRANICA

اطلاعات دوره: 
  • سال: 

    2014
  • دوره: 

    52
  • شماره: 

    10
  • صفحات: 

    752-756
تعامل: 
  • استنادات: 

    0
  • بازدید: 

    29045
  • دانلود: 

    8399
چکیده: 

One of the most preventable causes of mental and growth retardation is congenital hypothyroidism (CH). This study tries to investigate growth and mental outcome of patients with CH. Since November 2006 and November 2007 in Guilan province, north of Iran, all neonates who were diagnosed with CH, evaluated for etiology of CH by laboratory follow up, thyroid sonography or scan. Growth and development of patients with CH were compared with healthy children in same age, geographical area, social and economic classes in four years old. Demographic characteristics including height, weight, and head circumference at birth, follow up time (four years old) and IQ (Good enough test) were recorded in questionnaires. Among 28904 screened neonates, 37 patients with CH were diagnosed. Incidence of CH was 1: 781 in live births, 20 (54%) in female neonates and 17 (46%) in male neonates. The incidences of permanent and transient hypothyroidism were 43.2% (16 cases) and 56.8% (21 cases) respectively. The incidence of permanent and transient hypothyroidism were 16 (43.2%) and 21 (56, 8%), respectively. In permanent CH, 11 cases (%.68.2) had dyshormonogenesis and 5 cases (%.31.2) had thyroid dysgenesis. Significant statistical difference was only in family history of thyroid disease (34, 3% Positive family history in CH vs.13.2% in control group, P-value 0.03). All other demographic characteristics and IQ had no statistical difference. Patients with CH diagnosed through neonatal screening and treated had normal growth as general population that indicates effective screening program and treatment in this area (3.2%).

آمار یکساله:  

بازدید 29045

دانلود 8399 استناد 0 مرجع 3996
نویسندگان: 

اطلاعات دوره: 
  • سال: 

    2017
  • دوره: 

    -
  • شماره: 

    -
  • صفحات: 

    11-11
تعامل: 
  • استنادات: 

    315
  • بازدید: 

    1336
  • دانلود: 

    9195
کلیدواژه: 
چکیده: 

آمار یکساله:  

بازدید 1336

دانلود 9195 استناد 315 مرجع 0
اطلاعات دوره: 
  • سال: 

    2005
  • دوره: 

    15
  • شماره: 

    45
  • صفحات: 

    83-91
تعامل: 
  • استنادات: 

    0
  • بازدید: 

    14996
  • دانلود: 

    9195
چکیده: 

Background and purpose: congenital hypothyroidism (CH) is one of the preventable causes of mental retardation, which according to its clinical manifestations within the neonatal period, can be diagnosed in only fewer than 10% of cases. Delayed diagnosis results in irreversible cerebro-auditory complications unless the problem is diagnosed by screening programs.Materials and methods: From May to December 2003, serum T4 and TSH concentrations of 3005 newborns on the 3rd - 7th day of their birth were measured by RIA and IRMA, respectively in all Kashan hospitals. The newborns with abnormal screening results were reexamined (TSH> 20 mIU/L, T4<6.5 µg/dl and based on the weight). Newborns with TSH >10 mIU/L and T4<6.5 µg/dl on the second measurment were considered to be hypothyroid. After performing complementary tests, replacement therapy with levothyroxine was begun in neonates with CH.Results: From 3005 neonates, 51 newborn were recalled (recall rate=1.7%) and 10 newborns were diagnosed as hypothyroid cases. The prevalence of neonatal hypothyroidism was estimated to be 1/303.Conclusion: Considering the high prevalence of CH in the population, the necessity of routine neonatal screening programs is emphasized.

آمار یکساله:  

بازدید 14996

دانلود 9195 استناد 0 مرجع 0
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