Background & Aims: The outbreak of coronary heart disease in December 2019 in Johann, China, has infected the entire world (4). Corona is also widespread in Iran and endangers the physical and mental health of individuals (5). Recent studies have shown that negative emotions (such as anxiety, depression, and anger) increase during a pandemic, while positive emotions such as happiness and life satisfaction decrease (7). Also, the results of Hagh gadam et al. (2016) research in Iran showed that during the pandemic of this virus, many psychological problems such as anxiety and depression in people with increased and mental health of people have been affected by this disease (8). As mentioned, people's anxiety has increased in this critical period and along with this anxiety, death anxiety has also increased in people (9). Death anxiety is a complex concept that includes the fear of death for oneself and others (10). Anxiety about death is defined as an unusual and great fear of death with a feeling of dread of death or apprehension when thinking about the process of dying or what happens after death (14). Levels of death anxiety in individuals can vary due to individual differences and many social factors (15). Given the prevalence of the coronavirus, another important issue that has been addressed is the quality of life of people in the community. Quality of life is recognized as a component of health and is used to evaluate health care plans and anticipate needs related to social and health care (16-17). One of the factors that can be effective in predicting death anxiety is emotional cognitive regulation strategy. The concept of emotional cognitive regulation refers to the methodology of managing emotionally motivated information (21) and the cognitive part of coping, and emotion regulation through thoughts and cognitions has an inevitable relationship with human life. After experiencing stressful events, people are helped to manage their emotions (22). In a study, they stated that people with social anxiety disorder have less self-efficacy in using cognitive reassessment (27). Also, in another study by Qasempour et al. (2012) there is a significant correlation between cognitive emotion regulation strategies and death anxiety (28). Cognitive emotion regulation strategies also affect quality of life. A study showed that there is a positive and significant relationship between cognitive emotion regulation strategies and quality of life and quality of life can be predicted using cognitive emotion regulation strategies (29). In another study, Rostami et al. (2016) adaptive strategies for emotional regulation have a positive effect on quality of life (30). There is also a positive relationship between coping strategies with emotion and quality of life (31). identify people prone to psychological disorders at different levels of society in order to maintain the health of these people with appropriate psychological strategies. Therefore, the aim of this study was to investigate the Predicting death anxiety and quality of life based on cognitive emotion regulation strategies in the COVID-19 epidemic. Methods: The research design was correlational. The statistical population included all ordinary people in the city of Babylon. The research sample was 200 ordinary people in Babol who were selected based on the call and by available sampling method. Measurement tools included Cognitive Emotion Regulation Questionnaire (CERQ-P), Templer Death Anxiety Questionnaire and WHO Quality of Life Questionnaire. Data analysis was performed using Pearson torque correlation and multiple regression analysis. Results: The results of regression analysis showed that positive strategies of cognitive emotion regulation, ie acceptance, positive refocus, refocus on planning, positive reassessment and taking a total view (β,=-0. 113) can significantly predict death anxiety. Negative cognitive emotion regulation strategies, namely self-blame, rumination, blaming others, and catastrophe combined (β,= 0. 104) are significantly able to predict death anxiety, and positive cognitive emotion regulation strategies as a whole (β,= 0. 164) Are able to significantly predict the quality of life and also negative cognitive emotion regulation strategies as a whole (β,= 0. 281) are able to predict the quality of life. Conclusion: The results showed that there is a significant negative relationship between positive strategies of emotional cognitive regulation and death anxiety, but there is a significant positive relationship between negative strategies and death anxiety. Here we can refer to the research (39-39). Findings of this study show that positive emotional cognitive regulation strategies are negative and negative emotional cognitive regulation strategies are positively for predicting and explaining anxiety disorders. In fact, people who use negative emotional cognitive regulation strategies are more prone to emotional problems than others. Anxiety is death, and people who use positive emotional cognition are less vulnerable to emotional problems such as anxiety than others. Explaining the effect of cognitive emotion regulation strategies on emotion and anxiety (including death anxiety) Since cognition, emotion, emotion and behavior are completely interacting with each other, cognitive emotion regulation by controlling attention and cognitive consequences of emotion changes cognitive memory function, Decision-making and awareness) and then emotion regulation (28). Explaining this finding, it can be said that positive strategies that are adapted strategies to deal with stressful events improve self-esteem, social competence, etc., in contrast to negative strategies that are not compromised strategies to deal with stressful events cause stress, depression, Other psychological injuries, etc. (41). Another important point is that the use of negative strategies is associated with the lack of proper management of emotions in the face of everyday life events and causes symptoms or developmental disorders such as depression and anxiety. In other words, bias in the interpretation of social environment events leads to erroneous hypotheses about oneself and the social environment, which leads to a negative evaluation of social situations (9). Also, positive strategies have a positive relationship with quality-of-life indicators and negative strategies have a significant negative relationship with quality-of-life indicators, which is consistent with the research of Ramesh et al. (2018) and Craciun (2013) (42, 43). In fact, those with adaptive cognitive emotion regulation strategies are more skilled and turn stressful events into an opportunity to learn rather than see it as a threat to their safety. Eventually, they develop fewer physiological and emotional disorders. Naturally, their lives will be of a better and higher quality (20). In other words, cognitive emotion regulation strategies, which are an important part of life skills, have a more significant role in improving the quality of life (44). In fact, these strategies are a necessity for life (45) which leads to an increase in quality of life (46). If people learn to manage their emotions and negative emotions and experiences properly, use adaptive strategies in regulating their emotions, they will be able to have a good and effective relationship with others, have progress, social support and consequently a higher quality of life. (47). This study, like other studies, had some limitations, including the fact that in this study, due to the conditions in the community, it was not possible to access the samples in person and the questionnaires were collected online, which may lead to more bias. Also, due to the online nature of the questionnaire, people who were not able to use cyberspace were not included in the research, which limited the generalizability of the results. It seems that cognitive emotion regulation strategies can predict death anxiety and quality of life in the COVID-19 epidemic.