Biodiversity WEEDs marginal lands as a contributing factor in the distribution and spatial distribution of pests and also can be used as trap plants or habitat for beneficial insects and original product to protect against pests. The purpose of this study was to investigate the biodiversity changes of WEEDs in the margins of the wheat crop system that were affected by the use of herbicides. So this experiment in a randomized complete block design with four replications was performed College of Agriculture Branch. Treatments include: Axial 450 ml per hectare, Axial + Logar Extra respectively 450 ml and 200 grams per hectare, Axial 650 ml per hectare, Axial + Logar Extra respectively 650 ml and 200 grams per hectare, Thread + Granstar respectively 1 liter and 25 grams per hectare, Axial + Granstar at 450 ml and 25g/ha, respectively Axial + Granstar respectively 450 ml and 25 g per hectare, Treatments with the WEEDing and WEED control. The results showed that, Marginal biodiversity with the lowest density and dry weight of one-year yellow alfalfa (Melilotus officinalis L) WEED in treatment with application of herbicides Axial 450 ml + Logran Extra 200 g/ha and the lowest Density and dry weight of wild mustard (Sinapis arvensis L) in the treatment with application of herbicides Axial 650 ml + Logran Extra 200 g / ha and the lowest density and dry weight of wild oat WEED (Avena ludoviciana L) in Treatment with herbicides Axial 650 ml + Logran Extra 200 g / ha was observed. Therefore, by using and increasing the effectiveness of herbicides Axial + Logran Extra, it reduced the biodiversity of WEEDs in the margins of the herd system compared to other herbicides. The highest value of Shannon-Wiener diversity index based on WEED density (in 0. 25 m2) was observed in WEEDing treatment with 0. 643 and the lowest in Axial treatment of 650+ Logran 200 with 0. 397. Therefore, due to the decrease in Shannon-Wiener diversity index and WEED density and dry weight, we will have special concerns in reducing plant biodiversity along the ecosystem of irrigated systems due to the use of chemical herbicides.