Introduction: One of the most important threats for employees working in chemical industries is exposing to the chemical materials. Lack of precaution and control regulations during working with chemicals can have irreparable consequences. So, in order to achieve an effective control program, it is necessary to have an appropriate assessment of the procedures involving exposure to the chemicals. William-fine method can provide an acceptable insight into hazard risk rate.Material and Method: In this study, a combination of AHP and William-fine adopted to achieve a model for chemicals exposure risk assessment in oil and gas industry. The numbers were extracted from questionnaire, and then, they weighted entered to assessment the model. Finally, they were presented quantitatively with protection layer.Result and Conclusion: The results revealed that the quantitative amount of consequence, probability and exposure was 83.2, 8.45, and 2.2, respectively. Generally, the chemical exposure risk number was 1546 which shows that reforming plans are in highly priorities from an economical point of view. William-fine method has the benefit of an accurate chemical exposure by combination of effect severity, exposure probability and detriment rate, and also minimization of personal judgments during the assessment.