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مرکز اطلاعات علمی SID1
اسکوپوس
دانشگاه غیر انتفاعی مهر اروند
ریسرچگیت
strs
Issue Info: 
  • Year: 

    2021
  • Volume: 

    24
  • Issue: 

    8
  • Pages: 

    0-0
Measures: 
  • Citations: 

    0
  • Views: 

    29356
  • Downloads: 

    29939
Abstract: 

The recent pandemics caused by coronavirus infections have become major challenges in 21st century human health. Scientists are struggling hard to develop a complete cure for infectious diseases, for example, drugs or vaccines against these deadly infectious diseases. We have searched papers on thymoquinone (TQ) and its effects on different infectious diseases in databases like Pubmed, Web of Science, Scopus, and Google Scholar, and reviewed them in this study. To date research suggests that natural products may become a potential therapeutic option for their prodigious anti-viral or anti-microbial effects on infectious diseases. TQ, a natural phytochemical from black seeds, is known for its health-beneficial activities against several diseases, including infections. It is evident from different in vitro and in vivo studies that TQ is effective against tuberculosis, influenza, dengue, Ebola, Zika, hepatitis, malaria, HIV, and even recent pandemics caused by severe acute respiratory syndrome of coronaviruses (SARS-CoV and SARS-CoV-2). In these cases, the molecular mechanism of TQ is partly clear but mostly obscure. In this review article, we have discussed the role of TQ against different infectious diseases, including COVID-19, and also critically reviewed the future use of TQ use to fight against infectious diseases.

Yearly Impact:

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Author(s): 

Issue Info: 
  • Year: 

    2019
  • Volume: 

    234
  • Issue: 

    10
  • Pages: 

    0-0
Measures: 
  • Citations: 

    117
  • Views: 

    548
  • Downloads: 

    19710
Keywords: 
Abstract: 

Yearly Impact:

View 548

Download 19710 Citation 117 Refrence 0
Author(s): 

Journal: 

Curr Opin Ophthalmol

Issue Info: 
  • Year: 

    2019
  • Volume: 

    30
  • Issue: 

    3
  • Pages: 

    138-150
Measures: 
  • Citations: 

    409
  • Views: 

    6065
  • Downloads: 

    19588
Keywords: 
Abstract: 

Yearly Impact:

View 6065

Download 19588 Citation 409 Refrence 0
گارگاه ها آموزشی
Author(s): 

Journal: 

Cells

Issue Info: 
  • Year: 

    2020
  • Volume: 

    9
  • Issue: 

    5
  • Pages: 

    0-0
Measures: 
  • Citations: 

    165
  • Views: 

    501
  • Downloads: 

    13804
Keywords: 
Abstract: 

Yearly Impact:

View 501

Download 13804 Citation 165 Refrence 0
Author(s): 

O NEILL M.J. | BOURRE L. | MELGAR S.

Journal: 

DRUG DISCOVERY TODAY

Issue Info: 
  • Year: 

    2011
  • Volume: 

    16
  • Issue: 

    5
  • Pages: 

    203-218
Measures: 
  • Citations: 

    874
  • Views: 

    17995
  • Downloads: 

    24625
Keywords: 
Abstract: 

Yearly Impact:

View 17995

Download 24625 Citation 874 Refrence 0
Author(s): 

Journal: 

BIOMATERIALS

Issue Info: 
  • Year: 

    2020
  • Volume: 

    252
  • Issue: 

    -
  • Pages: 

    252-252
Measures: 
  • Citations: 

    187
  • Views: 

    1692
  • Downloads: 

    20198
Keywords: 
Abstract: 

Yearly Impact:

View 1692

Download 20198 Citation 187 Refrence 0
strs
Author(s): 

Journal: 

Cells

Issue Info: 
  • Year: 

    2020
  • Volume: 

    9
  • Issue: 

    4
  • Pages: 

    0-0
Measures: 
  • Citations: 

    453
  • Views: 

    1787
  • Downloads: 

    27477
Keywords: 
Abstract: 

Yearly Impact:

View 1787

Download 27477 Citation 453 Refrence 0
Issue Info: 
  • Year: 

    2020
  • Volume: 

    19
  • Issue: 

    3
  • Pages: 

    3-17
Measures: 
  • Citations: 

    0
  • Views: 

    15403
  • Downloads: 

    24208
Abstract: 

The objective of the current study was to systematically review the in-vitro anticancer activity of green synthesized gold nanoparticles (AuNPs) against hepatic cancer cells. The articles were identified through electronic databases, including PubMed, Scopus, Embase, Web of Science, Science Direct, ProQuest, and Cochrane. In total, 20 articles were found eligible to enter into our systematic review. Our findings showed that 65% of the articles used herbal extracts for the synthesis of AuNPs. Significantly, almost all of the articles stated the biofabrication of AuNPs below 100 nm in diameter. Impressively, most of the studies showed significant anticancer activity against HepG2 cells. Molecular studies stated the induction of apoptosis through the AuNPs-treated cells. We provided valuable information about the molecular mechanisms of AuNPs-induced cytotoxicity against HepG2 cells as well as their biocompatibility. The studies represented that AuNPs can be effective as anticancer drug nanocarrier for drug delivery systems. In addition, AuNP surface functionalization provides an opportunity to design multifunctional nanoparticles by conjugating them to diagnostic and/or therapeutic agents for theranostic purposes. Overall, our findings depicted considerable biogenic AuNPs-induced cytotoxicity, however, future studies should assess the anticancer activity of biogenic AuNPs through in-vivo studies, which was missing from such studies.

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Author(s): 

PARVEEN S. | MISRA R. | SAHOO S.K.

Journal: 

BIOLOGY AND MEDICINE

Issue Info: 
  • Year: 

    2012
  • Volume: 

    8
  • Issue: 

    -
  • Pages: 

    147-166
Measures: 
  • Citations: 

    456
  • Views: 

    49628
  • Downloads: 

    28312
Keywords: 
Abstract: 

Yearly Impact:

View 49628

Download 28312 Citation 456 Refrence 0
Author(s): 

MITTMAN N. | KNOWLES S.

Issue Info: 
  • Year: 

    2009
  • Volume: 

    16
  • Issue: 

    1
  • Pages: 

    156-162
Measures: 
  • Citations: 

    457
  • Views: 

    45427
  • Downloads: 

    28405
Keywords: 
Abstract: 

Yearly Impact:

View 45427

Download 28405 Citation 457 Refrence 0
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