Cell based Therapeutics is one of the most rapidly advancing medical fields, bringing together a range of fields including transplantation, tissue engineering and regeneration, biomaterials and stem cell biology. However, traditional cell-based Therapeutics have many limitations, one of which is their harmful effects exhibited on healthy body cells due to their lack of specificity. Nanomedicine is providing an alternative treatment strategy that is more targeted and specific to a range of diseases. Varying from polymers conjugated with drugs or tissue targeting molecules, to proteins encapsulated within a polymer shell, nanomedicine will without a doubt play a major role in designing effective cell-based Therapeutics that can overcome certain classical problems. These may include from addressing the problem of non-specificity of contemporary treatments to overcoming mechanical barriers, such as crossing cell membranes. This review summarises the recent work on nano-based cell therapy as a regenerative agent and as a therapeutic for cancer and neurological diseases.

Background: Up to now, different diet Therapeutics interventions have been introduced for the treatment of obesity. The present study aimed to compare the diet Therapeutics interventions for obesity simultaneously. Study design: Systematic review and network meta-analysis Methods: The major international databases, including Medline (via PubMed), Web of Science, Scopus, Cochrane Library, and Embase, were searched using a predesigned search strategy. Randomized controlled trials (RCTs) that had compared the diet therapy interventions were included. The mean difference with a 95% confidence interval was used to summarize the effect size in the network meta-analysis. The frequentist approach was used for data analysis. Results: In total, 36 RCTs out of 9335 retrieved references met the inclusion criteria in this review. The included RCTs formed nine independent networks. Based on the results, Hypocaloricdiet+Monoselect Camellia (MonCam, P=0. 99), energy restriction, behavior modification+exercise (LED) (P=0. 99), sweetener at 20% of total calories (HFCS20)+Ex (P=0. 67), catechin-richgreentea(650)+inulin (P=0. 68), very low calorie diet (VLCD) (P=1. 00), normal protein diet+resistance exercise (NPD+RT) (P=0. 80), low-calorie diets+exercise (Hyc+Ex) (P=0. 85), highsoy-protein low-fat diet (SD) (P=0. 75), calorie restriction+behavioral weight loss (Hyc+BWL) (P=0. 99) were the better treatments for weight loss in the networks one to nine, respectively. Conclusion: Based on the results of network meta-analysis, it seems that Hypocaloricdiet+MonCam, LED, HFCS20+Ex, catechin-rich green tea +inulin, VLCD, NPD+RT, Hyc+Ex, SD, Hyc+BWL, are the better treatments for weight loss in patients with overweight and obesity.