Background: Up to now, different diet Therapeutics interventions have been introduced for the treatment of obesity. The present study aimed to compare the diet Therapeutics interventions for obesity simultaneously. Study design: Systematic review and network meta-analysis Methods: The major international databases, including Medline (via PubMed), Web of Science, Scopus, Cochrane Library, and Embase, were searched using a predesigned search strategy. Randomized controlled trials (RCTs) that had compared the diet therapy interventions were included. The mean difference with a 95% confidence interval was used to summarize the effect size in the network meta-analysis. The frequentist approach was used for data analysis. Results: In total, 36 RCTs out of 9335 retrieved references met the inclusion criteria in this review. The included RCTs formed nine independent networks. Based on the results, Hypocaloricdiet+Monoselect Camellia (MonCam, P=0. 99), energy restriction, behavior modification+exercise (LED) (P=0. 99), sweetener at 20% of total calories (HFCS20)+Ex (P=0. 67), catechin-richgreentea(650)+inulin (P=0. 68), very low calorie diet (VLCD) (P=1. 00), normal protein diet+resistance exercise (NPD+RT) (P=0. 80), low-calorie diets+exercise (Hyc+Ex) (P=0. 85), highsoy-protein low-fat diet (SD) (P=0. 75), calorie restriction+behavioral weight loss (Hyc+BWL) (P=0. 99) were the better treatments for weight loss in the networks one to nine, respectively. Conclusion: Based on the results of network meta-analysis, it seems that Hypocaloricdiet+MonCam, LED, HFCS20+Ex, catechin-rich green tea +inulin, VLCD, NPD+RT, Hyc+Ex, SD, Hyc+BWL, are the better treatments for weight loss in patients with overweight and obesity.