INTRODUCTION: Human has been suffered from tuberculosis (TB) more than any other diseases. Prevalence of TB in Kurdistan province has not been determined yet. Estimation of TB prevalence is difficult and is usually approximated by using some global and local indices, which may be far from that virtually exist. This work was conducted to estimate TB prevalence in one of the SANANDAJ suburban regions, mainly to approach the difficulties of TB estimation in the field, in hope to facilitate further study in larger scales. MATERIAL& METHODS: In prevalence study using designed questionnaire, 1531 persons were screened based on demographic, general health condition, and clinical signs of tuberculosis. Persons with prominent signs of TB were evaluated clinically. Sputum of 24 persons suspected to TB was collected in three consecutive days and stained by Ziehl-Neelsen method and examined for Acid Fast Bacilli (AFB). RESULTS: Analysis of data in relation to constitutional signs of TB showed that 38 persons (2.5%) had coughing for more than 3 weeks, 67 (4.4%) had night sweating, 66 (4.3%) had loss of appetite and weight, and 7 (0.5%) had a history of hoemoptysis. Of 24 sputum 15 specimens were mainly saliva and one specimen was positive for AFB in all three successive day specimens, which mean 65 per 100000 prevalence for smear positive pulmonary tuberculosis in the region which has been studied. CONCLUSION: The results of this study showed that: 1- A combination of health staff, student and university workers can have good performance in field of research especially Health System Research (HSR). 2- People do not like to be known that have been affected. 3- The quality of sputum in most cases is not suitable. The estimated TB prevalence in the study region was much higher than the estimated of prevalence, for the country and which was done in the city of Bijar. The same study in a larger scale to obtain the prevalence of the disease is suggested.