As the Kor river water is applied for agricultural uses in Fars province and also urban, agricultural and industrial wastewater are poured to it, a study was carried out on variation of dissolved oxygen concentration and water quality parameters along the Kor river, from Band-e Amir to the Bakhtegan lake (specially in critical time) . Industrial pollution sources are located up the Band-e Air and also urban and agricultural pollutants are poured to the river through the Ahoochar drain. Therefore, 11 sampling stations were selected down the band-e Amir. Most of the selected stations are located in diversion barrages established for agricultural uses. In each station, two samples were taken for determination of dissolved oxygen, one sample for measurement of biochemical oxygen demand for seven days (BOD7) and the other for some parameters such as TDS, PH,… Then, dissolved oxygen content and its variation along the distance were studied and also effective factors in decrease and in create of it were calculated by means of Qualkor model which was compiled in visual basic. Results of such experiments are the presentation of oxygen sag curve which is applied for the Kor river in two separate situations (critical condition and under study condition). In this study, dissolved oxygen content along the distance was not decreased from 4 mg/L (standard Limit for aquatics), but in critical conditions, this amount was less than standard limit in all the stations except in the first station. Dissolved oxygen content reached zero between the stations 2 and 4, so aquatic life is confronted in danger.