A middle-aged woman suffering from jaundice and PRURITUS that had begun a month previously was presented to a physician. At the first assessment, laboratory findings had revealed a cholestatic pattern and serologic tests for hepatitis B virus (HBV), hepatitis C virus (HCV) and hepatitis A virus (HAV) were negative. Normal findings of abdominal computed tomography (CT) scan and endoscopic retrograde cholangiopancreatography (ERCP) ruled out extrahepatic causes of cholestasis. A liver biopsy was done and showed intrahepatic cholestasis without destruction of the bile ducts or granuloma. We assessed the intrahepatic causes of cholestasis. Finally the diagnosis was confirmed by means of a simple test.