Background and aim: Bacterial vaginosis is one of the most common infections of reproductive system, which results from replacement of the hydrogen peroxide-producing lactobacillus species by various anaerobic bacteria. Metronidazole is the choice of treatment for bacterial vaginosis, but it has many side effects. Drug resistance and recurrent occurs in 30-50 % of patients and new treatment options are needed to improve the efficacy of present treatment. PROBIOTICS are recommended for treatment of bacterial vaginosis. Efficacy of PROBIOTICS is discussed here.Method and materials: Electronic databases were searched for scientific publications about PROBIOTICS and bacterial vaginosis. These included: Pubmed, Ovid, Science direct and scopus. 40 publications were selected and reviewed.Results: PROBIOTICS are live microorganisms, including Lactobacillus species, that can be ingested and may beneficially affect the host. The mechanisms of lactobacilli function as anti-infective defenses are still not fully understood. These mechanisms may involve production of antimicrobial factors, maintenance of a vaginal pH of£4.5, enhancing barrier integrity, blocking bacterial adhesion to epithelia cells, improving immune system function producing vitamins and competing with pathogens. PROBIOTICS can be used as probiotic yoghurt or oral capsules.