The TENDON is a firm fibrous band of connective tissue that connects muscle to bone. This structure has the ability to transfer mechanical forces resulting from muscle contraction to the skeletal system. Tendinitis is a general term, often used to describe painful TENDON situations due to constant stretching, overuse, degeneration, or poor TENDON biomechanism. Tendinopathy is often the result of useless attempts by the body to regenerate a TENDON, which a pathological conflict has led to a malfunction. Various treatments have been used to manage TENDON disorders. Stem cells are divided into two categories. Embryonic cells (which are very potential but due to ethical considerations, limited studies have been done on them) and postnatal cells. Postnatal cells are divided into two categories, which include,Hematopoietic stem cells and mesenchymal stem cells. Mesenchymal stem cells have the ability to differentiate into multiple cells, including tenocytes, chondrocytes, and fibroblasts. these cells are a potential alternative to treating TENDON lesions. This article presentan overview of the structure, biomechanics and disorders of TENDON and, while pointing to the common therapies today, introduces stem cells, retrospective studies and possibility of using these cells in the optimal treatment of TENDON disorders.