Metastases are the most common malignant hepatic lesions and considered to be the most frequent indication for imaging of the liver. The accurate detectionandcharacterization of liver Metastasis remains a critical issue at the initial diagnosis of primary cancer or during the course of patient treatment. In the recent years, the advent of highly efficient imaging modalities and new techniques has facilitated the early detection of hepatic metastases. This can provide a unique opportunity for applying different treatment options including resection (like colorectal metastases) or radiologic interventional therapies. Optimized MDCT and MRI protocols and application of liver MRI specific contrast agents have also been promising in this agenda. The radiologist’ s knowledge from underlying histopathologic changes in different types of liver metastases can aid for accurate detection and interpretation of imaging findings. In this talk, the spectrum of imaging findings in hepatic Metastasis will be reviewed and new updates in technical aspects will be discussed.

INTRODUCTION:Cancer initiation and progression is a challenging scenario through developmental processes, which may be more complicated by occurrence of Metastasis. Basically, diverse genetic alterations, including mutations, formation of truncated proteins and related pathways play key roles either in diagnosis or the most influential therapeutic purposes. These may lead to an applicable preventive package against metastatic events [1]. By considering the biological and clinical characteristics, it has been stated that “Adolescent and Young Adult (AYA)” cancer patients are diversely defined compared to patients of older age groups. In this regard, it was aimed to investigate exceptional metastatic AYA cancer patients at genomic level and by considering the capability of molecular alterations in drug innovation [2]. …