A FIELD trial was conducted to evaluate the efficacy of two herbicides (2,4-D +MCPA and glyphosate) for weed control in wheat. This experiment was set up as randomized complete design was used with 3 replications at Ahwaz (Shavoor) research station in 2001-2002. Treatments were included: glyphosate (0.410, 0.820, 1.230 and 1.640 kg ai/ha) 2, 4-D+MCPA (1.350 kg ai/ha), weedy and Weed free. Treatments were applied about 20 days before harvesting. Among herbicide treatments, 2, 4-D+MCPA, 1.640 and 1.230 kg ai/ha of glyphosate had maximum weed control percent respectively. glyphosate in 0.410 and 0.820 kg ai/ha couldn’t manage bindweed satisfactory and Bindweed density and its weight had significant difference in comparison with glyphosate at 1.640 kg ai/ha and 2, 4-D+MCPA. Maximum regrowth rate of bindweed was observed in check (weedy) and 0.820 kg ai/ha glyphosate. Experiment treatment had same yield except check (weed free), that had maximum grain yield in first year of experiment because of weed control don’t effect on yield in harvesting stage. 2,4-D +MCPA, glyphosate at 1.640 and 1.230 kg ai/ha had maximum yield in second year. The results showed that effect of 2,4-D+MCPA was very rapid and its effect was observed after 5 days while effect of glyphosate was observed after 15 days.