Introduction: According to association of daytime symptoms, nocturnal enuresis is divided into 2subgroups: MONO-symptomatic (MNE) and nonMONO symptomatic (NMNE) forms.This study was conducted to review clinical and ultrasonography findings in different subtypes of enuresis and compare organic and functional pathologies of lower urinary tract in children with MNE with those who have NMNE.Methods: During 3-year period neurologically normal children with enuresis who referred nephrology clinic were enrolled study. Urinalysis, urine culture, and ultrasonography were done forall. Voiding CystoUreteroGraphy (VCUG) was used to evaluate anatomy of lower urinary tract and Urodynamic Studies (UDS) were done to assess bladder function.Results: Hundred and eleven children enrolled study (60 boys and 51 girls). Forty-three (38.8%) with MNE and 68 (61.2%) with NMNE, aged 5 to 17 years. Constipation, encopresis, and urge incontinence were significantly more frequent in patients with NMNE + daytime incontinence (P<.05). Increased of bladder wall thickness and irregularity of bladder wall were the most common findings (P>.05). One patient with MNE and 9 with NMNE + daytime incontinence had vesicoureteral reflux (P=.02). Evidences of bladder dysfunction were noted in about half of patients who underwent UDS, with higher prevalence in cases with NMNE +daytime urinary incontinence (P>.05).Conclusions: Bowel symptoms and urological abnormalities of lower urinary tract are significantly more prevalent in cases with NMNE who have daytime incontinence. We recommend VCUG in patients with NMNE who have daytime incontinence.