Background: Although there are some studies on correlation between MIGRAINE headache and GI symptoms, they did not significantly support the correlation between MIGRAINE headache and acid peptic diseases. This case control study aimed to find such a correlation.Methods: There were 70 patients (5-15 years old) who had endoscopic documented acid peptic diseases. The frequency of MIGRAINE headache in this group and also in a group consisting of a sample of normal population (300 individuals) without any GI problem in the past year was determined by a questionnaire.Results: The frequency of MIGRAINE headache was determined in each kind of acid peptic disease in the patients, being 92.9%, 68.6%, 24.3%, 4.3%, and 4.3% among patients with gastritis, esophagitis, doudenitis, gastric ulcer, and duodenal ulcer, respectively. The frequencies of MIGRAINE headache among the normal population and acid peptic disease group were 11.3% and 22.9%, respectively. The difference was found to be statistically significant.Conclusions: Our findings showed a significant correlation between MIGRAINE headache and acid peptic diseases, especially esophagitis and gastritis. This result accords with that in some of the previous studies.

Background: Visual evoked potential (VEP) is regarded as a useful,reliable and non-invasive technique for the diagnosis of lesions in the optic pathway. This technique was used to investigate visual function in MIGRAINE. Materials and Methods: 53 MIGRAINE patients (27 MIGRAINE cases with aura and 26 common MIGRAINE cases) and 55 controls were prospectively enrolled in this study. Visual evoked potential using the pattern reversal stimuli was performed in all patients and controls, and abnormalities of visual evoked potential were evaluated. Results: In subjects with classic MIGRAINE mean latencies of the P100 wave was increased by 6.7% (P<0.05) compared with controls. Common MIGRAINE subjects did not show significant difference with controls in regard to P100 latency (P>0.05). Also no significant difference was observed in P100-N140 peak-to-peak amplitude between the patients and controls. Conclusion: The results of this study demonstrate subtle neuronal damage within the visual system of MIGRAINE patients which may be due to repeated transient ischemia experienced during the aura or more likely as a constitutional change.

Objective: Carnitine plays a significant role in fatty acid transportation in mitochondria and has been shown to have a prophylactic effect on adult MIGRAINE. The aim of this randomized controlled trial was to compare and evaluate the effects of L-carnitine supplementation versus propranolol in the prevention of pediatric MIGRAINE. Materials & Methods: A total of 60 pediatric patients with episodic MIGRAINE were randomly allocated to 2 independent groups to receive either 50 mg/kg/day L-carnitine or 1 mg/kg/day propranolol as a prophylactic drug. Frequency, severity, and duration of MIGRAINE attacks and headache disability based on the Pediatric MIGRAINE Disability Assessment Score (PedMIDAS) were studied at the baseline and after 2, 4, and 12 weeks. Results: A total of 56 patients were evaluated in the study: 23 girls (41%) and 33 boys (59%) with a mean age of 9. 7 ± 2. 1 years. Frequency of MIGRAINE headaches per month reduced from 11. 4 ± 7. 1 to 5. 34 ± 2. 4 in the L-carnitine group and from 10. 7 ± 6. 2 to 4. 96 ± 3. 9 in the propranolol group by the end of the study. Headache severity score was also reduced from 19. 38 ± 14 to 2. 88 ± 7. 4 and from 12. 92 ± 13 to 0. 82 ± 1. 3 in the L-carnitine and propranolol groups, respectively. We found a significant decrease in frequency, severity, and duration of headache attacks in both groups (P < 0. 01). No significant difference was observed between the efficacies of the 2 drugs. Conclusion: This study concluded that L-carnitine supplementation can play a prophylactic role in the management of pediatric MIGRAINE.