Search Result

745

Results Found

Relevance

Filter

Newest

Filter

Most Viewed

Filter

Most Downloaded

Filter

Most Cited

Filter

Pages Count

75

Go To Page

Search Results/Filters    

Filters

Year

Banks



Expert Group







Full-Text


مرکز اطلاعات علمی SID1
اسکوپوس
دانشگاه غیر انتفاعی مهر اروند
ریسرچگیت
strs
Author(s): 

SALEHI SAHAR | BODDOHI SOHEIL

Issue Info: 
  • Year: 

    2017
  • Volume: 

    6
  • Issue: 

    4
  • Pages: 

    175-187
Measures: 
  • Citations: 

    0
  • Views: 

    66797
  • Downloads: 

    56910
Abstract: 

Mucoadhesive buccal film is developed as a promising dosage form, which has prominent advantages because of drug delivery through buccal mucosa. New formulation of buccal films containing rizatriptan benzoate (RB) was prepared by solvent casting method using various concentrations of hydroxypropyl methylcellulose (HPMC K4M), polyvinyl alcohol (PVA), polyethylene oxide (PEO), glycerol, stevia, and goat buccal mucosa used as a model membrane. In this work, the effect of polymers and plasticizer concentrations on drug release profile, disintegration and dissolution time, mechanical properties, and mucoadhesive characteristics of films was studied. Scanning electron microscopy analysis revealed uniform distribution of RB in film formulations. Chemical compounds and thermal analysis of the films were studied by Fourier transform infrared spectroscopy and differential scanning calorimetry, respectively. The buccal films produced were uniform in drug content and thickness. All formulations have in vitro release of 98–102% between 40 and 80 min. Also ex vivo mucoadhesion strength was in the range of 0.205 ± 0.035 to 0.790 ± 0.014 N for all formulations. A formulation consisting RB (50 mg), HPMC K4M, PVA, and PEO (63 mg), glycerol (1.5 ml), stevia (5 mg) was selected as our optimum composition. More satisfactory results were obtained in terms of disintegration and dissolution time, mechanical properties, and mucoadhesive characteristics. In addition, it showed about 99.89% RB released in 45 min. The results suggest that RB-loaded mucoadhesive buccal films could be a potential candidate to achieve optimum drug release for effective treatment of MIGRAINE.

Yearly Impact:

View 66797

Download 56910 Citation 0 Refrence 0
Author(s): 

HANJANI A.M.

Issue Info: 
  • Year: 

    2006
  • Volume: 

    24
  • Issue: 

    80-81
  • Pages: 

    1-11
Measures: 
  • Citations: 

    0
  • Views: 

    2961
  • Downloads: 

    133
Abstract: 

Introduction: Mitral valve prolapse (MVP) is a known benign entity. However, in certain instances it may ensue cerebrovascular complication with ominous prognosis. This study was under taken in the past 9 years and 12 cases with mitral valve prolapse and cerebrovascular complications were diagnosed and their medical data were recorded. The main goals of this study were to try ana detect the possible risk factors and predisposing symptoms of stroke (including vertigo amorosis fugax faint and convulsion) in those patients, and to explore the possibility of prevention.Methods: MVP was diagnosed by physical examination and echocardiographic findings. The cases were divided clinically into two groups; group one which was hospitalized with cerebrovascular accident (CVA) as well paralysis. They include 6 cases aged between 18 and 42 years (average 33.5 years) with a male over female ratio was 2/4. Five out of 6 cases having had mitral regurgitation. Group 2 as the control group with 6 cases who were followed for 10-66 months at the cardiac clinic. Their age range was between 17 to 30 years (average age 22.5 years) one out of 6 had mitral regurgitation. The male to female ratio was 1/5. These cases with symptoms of risk factors as mentioned above were placed on Propranolol dipyridamol and aspirin with follow up of 10-66months (averaging 31 months).Results: In group 1 CT and MRI revealed embolic stroke in 4 cases and hemorrhage CVA in 2 cases, whereas in group 2 MRI and CT revealed ischemic changes without necrosis in 4 cases and normal pattern in 2 cases.Discussion: The conclusion of this study points to the fact that cases of MVP and true stroke as well as paralysis are older and patients with high risk symptoms such as faint, vertigo, convulsion, amorosis fugax, in combination with MVP which warrant the administration of anti thrombotic agents including aspirin dipyridamol while they are on Propranolol. The same is in cases with MVP associated with mitral insufficiency P.F.O. and MIGRAINE headache.

Yearly Impact:

View 2961

Download 133 Citation 0 Refrence 0
Journal: 

BINA

Issue Info: 
  • Year: 

    2004
  • Volume: 

    9
  • Issue: 

    4 (36)
  • Pages: 

    323-332
Measures: 
  • Citations: 

    2
  • Views: 

    647
  • Downloads: 

    195
Abstract: 

Purpose: To evaluate the epidemiologic and etiologic characteristics of patients with paralytic strabismus at Labbafinejad Hospital during the years 2000-200 I, Tehran-lran.Method: As a descriptive study, consecutive cases with extraocular muscles paralysis (according to signs of cranial nerves 3, 4, or 6 involvement and negative forced duction test) were enrolled in the study. Age, gender, duration of involvement, past medical history, intensity of muscle paralysis, deviometry, head posture, and etiology were evaluated.Results: Of 119 patients (75 male and 44 female) with mean age of 30.58± 22 years, 111 cases (%93.3) had unilateral involvement and 8 cases (%6.7) had bilateral involvement; 103 (%86.6) cases had isolated nerve involvement including sixth nerve paralysis (%33.6), fourth nerve  paralysis (%32.7), and third nerve paralysis (%20.2). The etiology was congenital in 32 patients (%26.9), vascular in 30 patients (%25.2), and traumatic in 27 patients (%22.7). Mean age was 13.8±10.3, 56.4±122, and 27.4±15.6 in these subgroups, respectively. Other etiologies like unknown, infective, myasthenia gravis, MIGRAINE, multiple sclerosis, and tumoral followed in frequency. Over 60% of cases with 4th nerve palsy were operated, of which the most successful method was inferior oblique myectomy. Half of cases with 6th or 3rd nerve palsies were operated and the most common method was R&R. Conclusion: The most common nerve involvement was the 6th nerve. Fourth nerve involvement was the most common etiology in congenital disorders and 6th nerve involvement was the most common in traumatic and vascular disorders.

Yearly Impact:

View 647

Download 195 Citation 2 Refrence 0
گارگاه ها آموزشی
Journal: 

DANESHVAR MEDICINE

Issue Info: 
  • Year: 

    2009
  • Volume: 

    16
  • Issue: 

    82
  • Pages: 

    59-66
Measures: 
  • Citations: 

    1
  • Views: 

    6753
  • Downloads: 

    437
Abstract: 

Background and Objective: Menorrhagia is defined as menstrual blood loss of greater than 80 ml per cycle. Heavy menstrual bleeding is a common cause of iron deficiency anemia may affect woman's quality of life. Considering importance of menorrhagia, the present study was designed to determine the effect of Vitamin E in the treatment of menorrhagia in patients with DUB.Materials and Methods: Sixty-two women were selected for the study (aged 20-45 years, BMI= 19/8-29 and regular menstruation). Patients who had systemic disease, abnormal pelvic ultrasound, abnormal pap smear or have used hormonal contraceptives, IUD, TL, breast feeding and had serum hemoglobin levels lower than 10 g/dl were excluded. Participants were given 400 IU vitamin E or placebo per day, beginning two days before the expected start of menstruation and continued through the first three days of bleeding and 50 mg ferrous sulfate, from the beginning of menstruation for 7 days. Treatment was continued over four successive menstrual periods. Menstrual duration and amount of MBL were measured using a validated Pictorial Blood Loss Assessment Chart (PBLAC). Hemoglobin assessment was performed both at the beginning and at the end of treatment. Patients' satisfaction and acceptability were also assessed at the endpoints of treatment.Results: Results indicated that PBLAC scores and menstrual duration in the two groups were reduced after the treatment. There were no statistically significant differences between to PBLAC scores after two months (P= 0.342) and four months (P= 0.568), Also, no difference was observed in the menstrual duration after two months (P= 0.738) and four months (P= 0.842) between the groups. In vitamin E group "patient satisfaction" (P=0.004), "desired future treatment"(P= 0.020) were higher than placebo. Conclusion: The results indicate that, vitamin E in comparison to placebo was not effective on menstrual blood loss and menstrual duration reduction. However, since vitamin E relieves menstrual symptoms such as dysmenorrhea, menstrual MIGRAINE and it reduces emotional stress moreover, vitamin E has no side effects; these may contribute to high satisfaction and acceptability in vitamin E group.

Yearly Impact:

View 6753

Download 437 Citation 1 Refrence 0
Author(s): 

KARIMZADEH P. | TOGHA M. | GHOFRANI M.

Issue Info: 
  • Year: 

    2006
  • Volume: 

    1
  • Issue: 

    2
  • Pages: 

    31-36
Measures: 
  • Citations: 

    0
  • Views: 

    78576
  • Downloads: 

    27289
Abstract: 

Objective: The term “Ataxia” refers to disturbances of body posture and movement that are normally controlled by the cerebellum, frontal lobes and the posterior columns of the spinal cord. The primary symptom and the most prominent feature of ataxia is abnormal gait which is characterized by lurching and wide base walking. Ataxia was considered acute, if it had occurred within the two preceding weeks. Knowing how frightening acute-onset Ataxia is for the family is not surprising that the condition prompts an immediate visit to the physician. Material & Methods: In view of the lack of information in our country, on the etiology of sudden–onset Ataxia, the authors enrolled 100 children with the chief complaint of acute loss of equilibrium, who came to the attention of the Pediatric Neurology Department over a two year duration (Sept.2001-Sept 2003); they were admitted to the Mofid Childrens’ Hospital and all necessary investigations were carried out. Results & Conclusion: The results revealed that Acute Cerebellar Ataxia was the most common cause of the problem, the second most frequent being drug intoxication, which most commonly occurred in patients, 2-4years old. The remaining causative factors in order of descending frequency consisted of infectious polyneuropathy, MIGRAINE, opsoclonus–myoclonus, brain tumor, acute disseminated encephalomyelitis, multiple sclerosis, and epilepsy.

Yearly Impact:

View 78576

Download 27289 Citation 0 Refrence 0
Issue Info: 
  • Year: 

    2013
  • Volume: 

    22
  • Issue: 

    85
  • Pages: 

    15-22
Measures: 
  • Citations: 

    0
  • Views: 

    63487
  • Downloads: 

    29245
Abstract: 

Introduction: Rheumatoid arthritis (RA), is the most common inflammatory rheumatic disease. It is a chronic, systemic and disabling condition. Comorbid depression and/or anxiety worsen the biological and psychological outcomes of the disease.Objectives: Determination of relative frequency of depression and anxiety in the patients with rheumatoid arthritis.Materials and Methods: In this cross-sectional study, during six months (September 22, 2011 - March 19, 2012), BECK-II and Zhung self-rating Anxiety Scale(SAS) questionnaires were completed for 180 randomly selected rheumatoid arthritis patients(based on 1987 ACR criteria), from Rheumatology clinic of Rheumatology Research Center of Guilan Medical University(during a week after rheumatologist visit). Based on the scoring system, if score of Beck -II questionnaire (21 items instrument to measure depression severity) is <= 10, the severity of depression is normal, patients with score 11-16 are classified in mild depression, 20-17 in borderline clinical depression, 21-30 in severe depression, and 31 and higher in extreme depression group. If score of SAS questionnaire (20 items instrument to measure anxiety severity) is <= 44, the severity of anxiety is normal, patients with score 45-59 are classified in mild to moderate depression, 74-60 in severe anxiety, 75 and higher in extreme anxiety group. Patients with brain organic syndromes, fibromyalgia, current users of more than 10 mg prednisolon per day, current users of antidepressant drugs, patients with previous history of mood disorders, any poor control medical conditions (including but not restricted to MIGRAINE headache and poor control diabetes mellitus,...) and patients in function class IV were excluded from the study.Results: In this study, the relative frequency of depression was: 8.9% (16 patients) mild, 7.8% (14 patients) need psychologist consultation, 23.3% (42 patients) moderate, 30.6% (55 patients) severe, and 22.2% (40 patients) extreme depression. As for the relative frequency of anxiety: 68.9% (126 patients) mild to moderate, and 13.3% (24 patients) were with severe anxiety. As shown, there was no anxious patient without depression. Also, a positive significant correlation was found between Beck-II and SAS scores (p=0.0001, r=0.787).Conclusion: High relative frequency of depression and anxiety indicates the need for a close cooperation between rheumatologists, psychologists and psychiatrists if the best rheumatoid arthritis management is to be achieved.

Yearly Impact:

View 63487

Download 29245 Citation 0 Refrence 0
strs
Author(s): 

KELISHADI R.

Journal: 

ARYA ATHEROSCLEROSIS

Issue Info: 
  • Year: 

    2005
  • Volume: 

    1
  • Issue: 

    1
  • Pages: 

    29-35
Measures: 
  • Citations: 

    0
  • Views: 

    84643
  • Downloads: 

    37389
Abstract: 

Chocolate is derived from cocoa beans -the fruit of the cacao tree or Theobroma cacao (the latin term: food of the gods). Recent published articles demonstrate that the quality and quantity of the antioxidants in cocoa and chocolate are very high and their flavonoids are believed to reduce the number of free radicals in the body that contribute to medical problems, such as cardiovascular disease and cancer and also to offer some anti-aging health benefits. Cocoa can lower the leukotriene / prostacyclin ratio and is shown to have beneficial effects on platelets and possibly inflammation and vessel dilation. They inhibit low-density lipoprotein (LDL) oxidation, raise the high-density lipoprotein (HDL) level and reduce the thrombotic tendency. Their antioxidant catechin content is four times that of tea. They help the body process nitric oxide. Their flavanols and procyanidins have inhibitory effects on hemolysis, they can also attribute as a defense against reactive oxygen species (ROS) and can inhibit their carcinogenic processes. Also they are shown to inhibit growth and polyamine biosynthesis of human colonic cancer cells. They contain tryptophan and anandamide, which lessen anxiety, promote relaxation and trigger the production of endorphins. Cocoa can prevent dental caries and may play a regulating role in the function of the immune system and prevent infectious and autoimmune diseases. It stimulates lactase enzyme activity.Although caffeine may be harmful in large dose, chocolate contains it in small amount in comparison to coffee and tea. Negative effects of chocolate on childhood hyperactivity and MIGRAINE as well as tension headaches are controversial. Since the theobromine content of chocolate relaxes the esophageal sphincter, patients suffering from heartburn should avoid it. Cocoa can trigger some allergic reactions such as atopic dermatitis.This article reviews the potential health benefits and disadvantages of cocoa & chocolate and suggests that their flavonoid-rich types are health beneficial and when consumed in moderation, along with other plant foods, can be part of a healthy diet.

Yearly Impact:

View 84643

Download 37389 Citation 0 Refrence 0
Author(s): 

MORADIAN TEHRANI M.

Issue Info: 
  • Year: 

    2002
  • Volume: 

    5
  • Issue: 

    2 (14)
  • Pages: 

    95-99
Measures: 
  • Citations: 

    0
  • Views: 

    5627
  • Downloads: 

    235
Abstract: 

Hypericum perforatum is traditionally used for the treatment of many diseases. This oral drop drug is recommended for relief of MIGRAINE pain and is also used as an anti - depressant. In this research we surveyed mutagenicity effects of Hypiran. Conducting the Ames test, we used Salmonella typhimurium which has mutated histidine operan and depends on histidine for its growth. The tester strains used were, TA98 and TA100 which can determine point mutations including frame shift and base pair substitution mutations. These strains can also grow and produce colonies in the presence of mutagen substances in minimal glucose agar medium. Hypiran drops were prepared in different volumes such as 10, 20, 50, 100, 200, 250 and 300 microliter and were exposed to TA98 and TA100 strains. TA98 and TA100 were cultured in media with minimum glucose agar; and the produced colonies were counted after 48 hours. The mean of revertant colonies in each group was compared with the mean of each corresponding control revertant colony. Using evaluation indices, the rates of mutation was calculated and dose -response curve plotted. Hypiran oral drops in many applied volumes can revert TA98 and TA100.It can establish point mutations including frame shift and base pair substitution mutation. Based on evaluation indices related to the Ames test, Hypiran drops are a mutagen. However, in order to obtain higher certainty, other mutagenicity tests must be performed.      

Yearly Impact:

View 5627

Download 235 Citation 0 Refrence 0
Issue Info: 
  • Year: 

    2010
  • Volume: 

    16
  • Issue: 

    3 (62)
  • Pages: 

    350-350
Measures: 
  • Citations: 

    1
  • Views: 

    1071
  • Downloads: 

    133
Abstract: 

Objectives: Dreams have an important role in psychoanalysis. For perfect psychiatric assessment, dream analysis is valuable but ignored as far in Iran. A few dream analysis methods exist and psychiatrists' knowledge about them is low. Hall van de castle is a unique test which is used in researches and diagnosis; but not used in Iran before. Method: This manuscript reports about the translation of original version in Persian and assessing its reliability and validity.This test evaluate characters, aggression, friendliness, sexuality, activities, success and failure, misfortune and good fortune, emotions, settings, objects and descriptive elements. Dreams is recorded and coded, and then relation between dream and psychiatric disorders is valuated. Results: Two studies have previously utilized this test for PTSD and schizophrenic patients in Iran. In present study in the forementioned test was used for assessment of dream content in patients with nocturnal MIGRAINE. Conclusion: We suggest this test for dreams content assessment and other researches especially in addiction.

Yearly Impact:

View 1071

Download 133 Citation 1 Refrence 0
Issue Info: 
  • Year: 

    2009
  • Volume: 

    6
  • Issue: 

    1 (SUPPLEMENT)
  • Pages: 

    70-70
Measures: 
  • Citations: 

    0
  • Views: 

    95640
  • Downloads: 

    30077
Keywords: 
Abstract: 

- Dizziness that patients complain from are rotational vertigo, sense of instability, ataxia of gait, disturbance of vision, loss of contact with surroundings, nausea, loss of memory, loss of confidence, epileptic convulsion and dizziness that is considered by medical staff are:1- Vertigo as a sense of feeling the environment moving when it does not persist in all positions, aggravated by head movement.2- Disequilibrium as a feeling of unsteadiness or insecurity without rotation, standing and walking are difficult.3- Light headedness as swimming, floating, giddy or swaying sensation in the head or in the room.Taking the history from a vertigo patient:*What the patient means by vertigo?-- Time of onset-Temporal pattern-Associated signs and symptoms '' tinnitus, hearing loss, headache, double vision, numbness and difficulty in swallowing''.- Precipitating, aggravating and relieving factors.- If episodic: sequence of events, activity at onset, aura, severity and amnesia.*Examination of the vertigo patient checking:Spontaneous nystagmus, positional nystagmus, optokinetic nystagmus, posture and balance control like romberg's test, blind walking, untenberger and barany's test, stimulation of labyrinth, caloric test '' cold, warm water '' and the rotational test.Etiology:*Spontaneous nystagmus:Posture and balance control is positive with nausea , vomiting , sweating and anxiety : harmonic vestibular sy with loss of hearing , tinnitus , vestibular neuronitis , meniere disease and with otologic origin and dysharmmonic vestibular sy , with numbness , double vision , dysarthria in brain stem infarct and with a neurological origin.Nonspontaneous nystagmus :Posture and balance negative with nausea, vomiting in GI disorders and internal medicine , sweating and trachycardia by chest pain in angina , M.I '' cardiology '' and anxiety in psychiatry.- Clinical differentiating of peripheral and central vestibular lesion should be done by separating harmonic and disharmonic vestibular syndrome.- Examination of the patient with vertigo '' laboratory and imaging''•Electronystagmography•Video-oculography•Audiometry•BAEP•CT•MRI - Common cause of vertigo '' all by image ''Peripheral: Physiological '' motion sickness'', benign paroxysmal positional vertigo , vestibular neuronitis , labyrinthitis , meniere disease , perilymph fistula.Central: Brain stem TIA/infarct , post. fossa tumors , M.sclerosis, syringobulbia ,Arnold -chiari , temporal lobe epilepsy and basilar MIGRAINE.Others: Cardiac , GI , psycogenic , mediacations , anemia and  hypotension , toxin and drugs:''aminoglycoside antibiotics,anticonvulsants,salycilates , alcohol , sedatives , antihistamins , antidepressants '' , cervical spondylosis , sensory deprivation ''neuropathy , visual impairment '',anemia , hypoglycemia , orthostatic hypotension and hyperventilation.

Yearly Impact:

View 95640

Download 30077 Citation 0 Refrence 0
litScript