The study done to determine the concentration of MERCURY inedib let issues and vital Anzalipike (Esox Lucius)and Relationship between body length, age and sex of the fishby the concentration of MERCURY. A total of58fish samples were taken from both east and west of the Anzali wetland After weighing, sexing and biometric target tissues to determine the concentration of lead was prepared by the specific analysis of the MERCURY,(American Standard Method D6722) analyzed. MERCURY concentrations in different organs suggest that the spleen may behigh concentrations of MERCURYin the absorption and accumulation. The liver compared to other organs studied, the lowest concentration of MERCURYin the absorption and accumulation. Comparison of MERCURY concentrations in male and female pikeindicate that MERCURY concentrations depend on gender and agepike is in Anzali lagoon. MERCURY concentrations in pike and pickerel Anzali wetlandeast of the western part of the difference is not significant. Nocor relation between size, weight and age pike in Anzali wetland up take and accumulation of MERCURY in them there. Significant differences between thes exesin terms of the concentration of MERCURY infish tissues was observed (p>0.05), which reflects the impact of genderon the adsorption of MERCURYspecies understudy. Between East and West Pond Fish Twomajorindustries and even though accumulation of pollutants in the eastern part of the lagoon, there was no significant difference. MERCURY level sinpike Anzali Wetland permissible limit recommended by the FDA and WHO/FAO (1 PPM)was lower than the average concentrations inppb 37/322 musclepikesin Anzali wetland and limitations directive US EPA, dose of 2times per month throughoutthe entire body and sexuality permissible Bashd. brrsyeffectofmetallic MERCURYac cumulationin the liver, kidney, spleen and musclepike Anzali Wetland.