Background and Aim: Based on recent studies, atorvastatin has some pleiotropic actions such as anti-inflammatory and anti-oxidant effects independent of lipid lowering effects. Regarding the critical role of oxidative stress and inflammation in inducing diabetic neuropathy, the current study aimed at examining the neuroprotective and anti-oxidative stress effects of atorvastatin atthe brain tissues in diabetes experimental models.Materials and Methods: Twenty-four male Wistar rats were randomly divided into 4 equal groups. including normal, normal treated, diabetic and diabetic treated. The diabetic group were made diabetic by an intravenous injection of streptozotocin (40mg/kg) and the treated group received 40mg/kg/day atorvastatin for 8weeks. At the end of the experiment, blood samples from the subjects were derived to measure their blood glucose and urea. Finally, the rats were killed under deep anesthesia and their brains were removed in order to measure MALONDIALDEHYDE (MDA) and to make histopathological assessment.Results: Uncontrolled hyperglycemia (blood glucose>450 mg/dl) significantly increased blood urea in the diabetic group (130±10 mg/dl) compared with the normal group (58±7 mg/dl), (P<0.05). Also, hyperglycemia increased brain MDA of the diabetic group (8.78±3.07mmol/mg protein) associated with mg/dl) accompanied by histopathological damages. Finally, the content of brain MDA significantly. decreased in diabetic rats treated with atorvastatin (0.92±0.31mmol/mg protein), (P<0.05).Conclusion: The findings of the present study reveal that atorvastatin is able to prevent hyperglycemia induced diabetic neuropathy and inhibit brain oxidative stress during diabetes. It is probable that reduction of urea is one of the reasons for atorvastatin prevention of hyperglycemia-induced neuropathy.

Introduction1: Selenium is an essential trace element, which plays a key role in the development of reproductive performance and animal safety. This mineral is an important part of at least 25 effective proteins in a variety of physiological functions, including increased resistance to oxidative stress, DNA repair, and improvement to reproductive performance and immune function. Despite the fact that selenium requirement of birds can be met by cornsoybean meal diet, dietary sodium selenite up to a maximum level of 0. 5 mg kg-1 is highly recommended to improve avian health and productive performance. However, interaction with other minerals, poor retention and lower deposition efficiency questioning the incorporation of sodium selenite into the diet. Vitamin E is the main antioxidant in egg yolk lipid terminating the lipid peroxidation chain by reacting with lipid peroxides and making them be stable. Diet supplementation with vitamin E could improve performance and egg quality and provided health benefits to laying hens. The positive effects of Se and vitamin E on egg production, egg quality traits has been extensively studied in laying hens, but information regarding the potential benefits of these antioxidants on the productive performance of Japanese quails is limited in literature. Thus, this study was conducted to investigate the combined effects of various sources of selenium (0. 4 mg kg-1) plus vitamin E (120 mg kg-1) on performance, qualitative characteristics, immune system and blood metabolites of Japanese quails. Materials and Methods: A total of 144 12-week-old female Japanese quails were randomly divided into three treatment groups with four replicates and twelve birds in each in a completely randomized design. The experimental treatments consisted of basal diet (with no supplementation) and two organic (sel-plex) and inorganic (sodium selenite) sources of selenium which provided 0. 4 mg/kg, plus 120 mg of vitamin E per kilogram of diet. Feed intake, feed conversion ratio (FCR), egg production and quality parameters in fresh and stored eggs, cell immunity, blood cholesterol, triglyceride and total antioxidant contents were evaluated. At the end of experiment, egg yolk selenium and MALONDIALDEHYDE concentrations were measured. The thiobarbituric acid reactive substances (TBARS) assay with small modification was used to measure lipid oxidation. Briefly, 2 grams of homogenous yolk was mixed with 5 mL of 20 % trichloroacetic acid (TCA) and 4 mL distilled water, and homogenized for 30 s at high speed. The homogenate was then centrifuged (1000 g for 20 min) and the resulting supernatant was filtered with Whatman Filter Paper (grade no. 1). Two mL of filtrated was mixed with 2 mL of thiobarbituric acid (TBA, 0. 02 M) in a test tube and heated in boiling water for 20 min. After cooling, the absorbance of the resulting solution was read with a spectrophotometer at 532 nm. Results and discussion: The results showed that egg weight, egg laying percentage and feed conversion rate were not affected by selenium organic and inorganic sources compared to control group (P > 0. 05). Birds receiving organic selenium along with vitamin E in their diets had low feed intake compared to other treatments and their feed conversion ratio numerically decreased and intended to significant (p<0. 1). The organic selenium plus vitamin E improved the height of white, HU units, yolk pH, and yolk index compared to control group. Egg quality parameters including yolk index and shell surf index in inorganic selenium group were significantly higher than control group (p<0. 0. 05). Egg yolk selenium was increased in organic and organic selenium (2. 06, 1. 31 mg/kg) compared to control (0. 36), which is a better value from the nutritional viewpoint. Blood cholesterol and triglyceride levels were not affected by experimental diets. Concentration of yolk MDA was highest in control and lowest in organic selenium group during storage (P < 0. 05). The result of this study showed that egg production, feed conversion ratio and total egg mass were not affected by experimental treatments. This was also observed by other researchers who evaluated the dietary inclusion of vitamin E. In another one egg quality parameters, however, egg weight was significantly raised after being fed with a diet contained 120 mg kg-1 of vitamin E and 0. 4 mg kg-1 of organic selenium.Conclusion: In conclusion, our study data revealed dietary organic selenium and vitamin E, could improve the egg quality during storage and increased egg yolk selenium of Japanese quails.

Introduction: Numerous biochemical reactions in human body produce active oxygen which is able to destroy biomolecules. This destructive effect of free radicals can be blocked by antiradicals. The role of free radicals in causing a noticeable number of disease has been proved. Anti-oxidants defend against these oxidative destructions. One of the best natural resources of oxidants are phenolic compounds in plants. Phenolic compounds by giving electrons to free radicals, restrain lipid oxidative reactions. Chemical antioxidants have been using a lot in food industrysuch as BHT, BMA, TBHQ and propyl gallate that their destructive and carcinogenesis effects on human body have been proved. Therefore, nowadays, the consumption of medicinal plants and their phenolic compounds as natural resources of antioxidants has been highly recommended. Different solvents and a variety of extraction methods can be used for extracting anti-oxidative compounds from plant tissues. Polarization degree of different solvents will effect on the amount of extracted phenolic compounds. Berberidacease family has a significant use in medicine and industry. There are biological activities in Barberry and it's highly used in food and medical industries. The main alkaloid of barberry is Barberine which has the anti-oxidative and anti-inflammatory properties and decreases blood pressure, hypoglycemia and lipid. Phenolic compounds and anthocyanins are the most important secondary active nutrients in Barberry. Barberry's extract and its bark root are rich in anti-oxidative and phenolic compounds.Berberis Integerrima × vulgaris has been studied in this research. The aim of this study was to determine the best solvent for extraction, the amount of phenolic compounds, anti-radical activity and anti-oxidative capacity in different extracts of fresh barberry which is gathered from Qamchoqai zone, Bijar, kordestan province.Materials and method: For this study, Barberries were collected from Qamchoqai zone located in Bijar, Kurdistan, Iran. They had been maintained in freezer till we started to examine them. Then, we prepared the ethanol, methanol and water extracts of these frozen Berberis. The total Phenol and Flavonoid contents of extracts according to the method of UV-VIS, Total antioxidant activity content of extracts by using three different methods including scavenging activity of DPPH, NO, reducing power assay and the capacity of inhibit lipid peroxidation by thiobarbituric acid were determined.Results and Discussion: In conclusion, this investigation demonstrates that Barberry is a rich source of phenolic compounds and antioxidant capacity. The aqueous extract showed the highest total phenol content (48.98±0.49 mg/g (wet weight)) and scavenging power of Nitric Oxide radical activity (%723.6±64.56) and the methanol extract showed the highest flavonoid content (1.93±0.033 mg/g (wet weight)), DPPH scavenging effect (%44.62±0.99), reducing power (5.89±0.42 mmol/g (wet weight)) and MDA content (37.12±0.79 mmol/g (wet weight). The type of solvent used for extraction has significant effect on phenolic compounds and flavonoids.Methanol extract has the minimum amount of phenol in fresh barberry, but methanol is a good solvent for flavonoids in barberry. The result of anti-oxidative effects in different extracts of barberry according to MDA scale shows that the water extract has the maximum amount of anti-oxidative activity. These activities in extracts are because of the existence of phenols which prevent lipid oxidation by removing free radicals and stop the increase of MALONDIALDEHYDE. In this study, Methanol extract has the maximum amount of anti-radical activity.These different results in extracts are due to the different phenolic compounds and flavonoids in them. Among extracts, water exract has the maximum capacity in trapping nitric oxide radical. Anti-radical activity against NO radicals probably is done by anti-oxidative compounds in barberry which competes with O2 over NO. In term of reduce power, extracts didn’t have significant difference with each other. FRAP and DPPH method was the same result. This means that the methanol extract than other extracts showed higher antioxidant activity. In the extraction of phenolic compounds, Organic solvents especially methanol, was more effective than water and possibly "phenolic compounds derived regenerative better by methanol extract. Results showed that aqueous and alcohol extracts of Berberis Integerrima×Vulgaris can act as a natural antioxidant and after complimentary expriments, it can be used in food and medecine industry.

Objective (s): Previous research demonstrated that diabetes is one of the leading causes of learning and memory deficits. Naringin, a bioflavonoid isolated from grapefruits and oranges, has potent protective effects on streptozotocin (STZ) ‐induced diabetic rats. Recently, the effects of naringin on learning and memory performances were monitored in many animal models of cognitive impairment. However, to date, no studies have investigated the ameliorative effects of naringin on diabetes‐associated cognitive decline (DACD). In this study, we investigated the effects of naringin, using a STZ‐injected rat model and explored its potential mechanism.Materials and Methods: Diabetic rats were treated with naringin (100 mg/kg/d) for 7 days. The learning and memory function were assessed by Morris water maze test. The oxidative stress indicators [superoxide dismutase (SOD) and MALONDIALDEHYDE (MDA)] and inflammatory cytokines (TNF‐a, IL‐1 b, and IL‐6) were measured in hippocampus using corresponding commercial kits. The mRNA and protein levels of PPARg were evaluated by real time (RT) ‐PCR and Western blot analysis.Results: The results showed that supplementation of naringin improved learning and memory performances compared with the STZ group. Moreover, naringin supplement dramatically increased SOD levels, reduced MDA levels, and alleviated TNF‐a, IL‐1b, and IL‐6 compared with the STZ group in the hippocampus. The pretreatment with naringin also significantly increased PPARg expression.Conclusion: Our results showed that naringin may be a promising therapeutic agent for improving cognitive decline in DACD.

Introduction: Instant soup is a type of convenience food which is commercially produced for ease of consumption, portable and has a long shelf life. According to quick preparation and inexpensive, it becomes quite popular for people too short on time in the modern world. Instant dried soup powder is meat or vegetable-based product and generally constituted mixture of dehydrated cereals, vegetables and spices. However, interesting in consuming convenience foods has been received criticism due to lack of nutritive value and other health concerns. On the other hand, seafood industry generates great amount of edible wastes or by-products which can be highly perishable and needed to process in various value added products. Beluga or great sturgeon (Huso huso) is an endemic fish species of the Caspian Sea and extremely cultured for meat and caviar purposes in many countries in particular Iran. According to big size of farmed sturgeon, the fish fillet is commonly raw material for consumers, but unfortunately the wastes from the fillet producing and trimming are usually discarded or used for relatively low commercial value products (e. g. fishmeal and oil production). Treated fish waste described as an edible offal or edible by-product which can also be used for various value added products instead of being discarded and causes potential adverse environmental impacts. Fisheries products are highly perishable, while dried fish soup powder can be stored for a long time due to lower water activity. On the other hand, protein deficiency in some countries or low per capita consumption of seafood can be compensated by the production of a variety of fish products. The production of ready-to-eat soups from fish due to their high nutritional value can be considered as a healthy food among other instant foods. This study aimed to use farm-raised beluga sturgeon by-products in instant soup powder, as well as its shelf-life at ambient temperature for 120 days. Material and methods: At first, the fresh beluga fish wastes were processed and dried till lower 10% moisture. Then, the beluga fish powder at 0% (control; vegetable soup), 20%, 35%, 50%, and 65% was used in instant soup formulas to specify the best formula. Then, some physical properties (i. e. color, water activity, and water holding capacity) and chemical properties (i. e. proximate composition, pH, TVN, PV, TBARS, FFA, and fatty acids profile) were compared among the best formula fish soup and control. Results and discussion: The highest overall acceptance score (4. 70) was obtained in 50% beluga fish formula and selected as a best formula. After 4 months of storage, free fatty acid (8. 87%), peroxide value (7. 30 meq. O2/kg), thiobarbituric acid-reactive substances (0. 1 mg of MALONDIALDEHYDE in kg), and total volatile basic nitrogen (2. 87 mg/100 g) was within the permitted ranges. Also, pH of vegetable soup (7. 57) was lower than fish soup (7. 82). Water activity was lower than 0. 5 in both types of soup samples during storage. The amount of  E in fish soup was changed from 1. 21 at the begging of the experiment to 2. 83 after 120 days. The results showed that fish soup is a good source of high unsaturated fatty acids, and their amounts were decreased during the storage time, especially eicosapentaenoic acid and dicosas hexanoic acid were decreased to 2. 01% and 4. 14%, respectively. Conclusion: The results of this study showed that the use of 50% of dried beluga sturgeon fish meat in the instant soup formulation received the highest sensory evaluation points compared to other formulas and was selected as the best formula. Study of changes in chemical indices showed that all the measured factors were in the allowed range after 4 months of storage under ambition condition. Also, water activity was lower than the critical level for the growth and activity of spoilage microorganisms. Increasing in the storage time led to a decrease in water holding capacity and whiteness of the fish soup. In addition, unsaturated fatty acids including oleic acid, linoleic acid, and linolenic acid were more susceptible to oxidation during storage, and decreased over the shelf-life. Therefore, fish soup with high protein content (55% in dry weight) and high unsaturated fatty acids has a high nutritional value and can provide an enriched instant soup with a high nutritional value and appropriate shelf life up to four months.

Background: Serum levels of triglycerides (TGs) are often found to be raised in type 2 diabetes mellitus (T2DM). TG levels³ 2.2 mM, systemic inflammation and oxidative stress (OS) are known to increase the risk of incident cardiovascular disease (CVD) substantially.In recent years, apolipoprotein A-V (Apo A-V protein) has attracted considerably as a modulator of circulating TG levels.Objectives: The study was conducted in order to evaluate the levels of Apo A - V proteins and markers of inflammation and OS in patients of T2DM with and without hypertriglyceridemia (HTG) and also to assess correlation between them.Methods: T2DM patients were categorized into two groups of 40 participants, according to criteria for risk of CVD: group 1/ controls (TG£ 1.65 mM, n=40) and group 2/ cases (TG ³ 2.2 mM, n=40). Despite the routine investigations, serum levels of Apo A-V, interleukin-6 (IL-6) and Insulin were estimated using ELISA, free fatty acids (FFA) with fluorometric assay and MALONDIALDEHYDE (MDA) was measured using a spectrophotometer. Comparison of levels and correlation between variables was carried out with appropriate statistical tools.Results: Serum Apo A-V protein levels were found significantly lower (P=0.04) and MDAwas significantly higher (P=0.049) in cases.MDA correlated with TG levels positively (P=0.000) and negatively with high density lipoproteins (HDL) (P=0.000). However Apo A-V protein levels did not correlate with TG levels (P=0.819, r=-0.027), IL-6 (r=0.135, P=0.269), FFA (r=0.128, P=0.277) and MDA (r =-0.217, P=0.073). IL-6 levels significantly and positively correlated with HOMA-IR (r=0.327, P=0.004) in the all patients.Conclusions: In patients of T2DM, low levels of Apo A-V are associated with HTG, indicating that Apo A-V is linked with TG metabolism. Burden of oxidative stress is greater in HTG of T2DM as is evident from MDA levels and its correlation with TG levels.Since oxidative stress is an important patho-physiological basis which increases the risk of CVD in patients of T2DM with HTG.Further studies are required in order to explore the possible role of Apo A-V in TG metabolism in diabetes.

Background and Objective: Cardiovascular disease is the major cause of morbidity, mortality and disability in the world and Iranian population. Inflammation and oxidative processes are major risk factors of atherosclerosis. Some evidence demonstrated antinflammatory effect of conjugated linoleic acids (CLA) and omega-3 fatty acids (w-3 fatty acids). So the aim of this study was to evaluate the effect of CLA and w-3 fatty acids supplementation on inflammatory and oxidative stress markers in atherosclerotic patients.Materials and Methods: In this study 90 volunteers who referred to Emam Reza Heart Clinic of Shiraz University of Medical Sciences were selected if they fulfilled the inclusion criteria. Participants were classified into 3 groups receiving 3g/d CLA, 1920mg/dw3 or placebo for 2 months. C-reactive protein (CRP), interleukin -6 (IL-6), MALONDIALDEHYDE (MDA) and glutathione peroxidase (GPx) were measured before and after supplementation. CRP measurement was done by a high sensitive Enzyme Linked Immunosorbent Assay and IL-6 assay was performed by Radioimmunoassay methods. GPx enzyme activity and MDA was measured byspectrophotometery. Data processing and statistical analysis were done using SPSS19 software and a p-value of <0.05 was considered as statistically significant.Results: hs-CRP level decreased significantly in both the w3 and CLA group during the study (4.43±4.13 vs 1.6±1.41 and 7.48±5.64 vs 5.95±5.87) (p=0.01). IL-6 reduced significantly in w3 groupralative to control (18.59±11.12 vs 13.37 ± 9.44) (p=0.04) but in CLA group reduction in IL-6 levels was not significant (16.13±10.21 vs 12.95±8.1) (p=0.06). GPx increased in CLA andω3 groups (144.57±56.89 vs 174.61±62.8 and 125±46.06 vs 171.4±68.90) (p=0.001). MDA level decreased significantly in both the w3 and CLA group (3.98±1.50 vs 2.87±1.55 and 3.7±1.77 vs 2.4±0.8) (p=0.001).Conclusion: Supplementation of diet with CLA and w3 can have a beneficial effect on some indices of inflammatory and oxidative stress.

Aim: Investigating the effect of catechin hydrate (CH) and boric acid (BA) on rat bone marrow mesenchymal stem cells (MSCs).material and Methods: MSCs were treated with culture media containing CH, then with the help of trypan blue the viability was investigated at 12, 24 and 36hours. 400 and 3200mM of CH along with 6ng/ml of BA and 36hours were selected for further study. Proliferation based on colony forming assay (CFA) and population doubling number (PDN), morphology, level of sodium, potassium and calcium and activity of LDH, ALP, AST, ALT were analyzed. MALONDIALDEHYDE (MDA), total antioxidant and activity of SOD and CAT were measured too.Results: only 3200mM at 12hours and from 400 to 6400µM at 24 and 36 hours, the CH caused significant reduction in viability, proliferation, nuclei diameter and cytoplasm area. Treatment with CH caused increase in activity of LDH, ALP, AST, ALT and increased in FRAP as well as reduction of MDA and sodium, potassium level. BA did not show any effect on viability, morphology and PDN but caused reduction of CFA and activity of LDH, AST and ALT. BA also caused elevation of ALP activity and level of calcium, sodium, potassium as well as MDA level and activity of CAT and SOD. Co-treatment compensated the viability, proliferation, morphological changes, metabolic enzyme activity variation and level of electrolyte to some extent. On the other hand, co-treatment showed, CH ameliorated the oxidative stress induced by BA.Conclusion: since boron ameliorated the CH toxicity, along with tea we may consume dry grapes and dates.

Introduction: In present study the effect of vitamin E on diabetes induced nephropathy, plasma antioxidant capacity and lipid peroxidation was investigated. Materials and Methods: 24 male wistar rats with average body weight of 250±20 gr were chosen. 16 rats, diabetized by STZ (60 mg/kg B.W, i.p) were divided into 3 groups (n=8) of non-diabetic, diabetic non-treated and diabetic treated with Vit.E (300 mg daily). After 8 weeks all rats were anaesthetized by hydrate chloral. After blood sampling, kidneys were removed and kept in 10% formalin buffer. Plasma and red blood cells of blood samples were separated. Plasma antioxidant capacity by FRAP method, and MALONDIALDEHYDE (MDA) as lipid peroxidation indicator were measured. Also renal samples were studied for focal cell proliferation and glomerule and tubule structural changes. Results: MDA in non-diabetic, diabetic and diabetic treated with Vit.E rats was 126.14±6.6, 245.2±17 and 170.8±9 nmol/grHb respectively. Significant attenuation of MDA in diabetic treated with Vit. E rats showed decrease of lipid peroxidation in comparison to the diabetic non treated group (P<0.01). Antioxidant capacity in the three groups mentioned was 582.7±23.33, 586.2±23.79 and 808.7±30.82 mmol/lit respectively. Plasma antioxidant capacity in Vit.E treated rats showed significant augmentation comparing to the first two groups (P<0.05). In the non-treated rats, glomerule diffused proliferation, cell diffused inflammation and hyaline changes were seen; arteries walls also shows thickening. These changes were significantly reduction in rats treated with Vit. E. Conclusion: This study showed that Vit. E causes decrease the oxidative effects stress and improve diabetes induced nephropathy.

ENGLISH: Chemotherapy is the main approach for the treatment of cancer; however, it often causes unpleasant oxidative damages. Therefore, the development of an effective alternative/complementary therapy with improved tumor suppression efficiency and lower adverse effects is highly required. Recently, it has been shown that Cyrtopodion scabrum extract (CsE) is an effective and selective tumor suppressor medicine. The present study investigated the antioxidant activity of Cyrtopodion scabrum homogenate (CsH) and CsE and their effects on attenuating 5-fluorouracil (5-FU)-induced liver dysfunction in rats. A total of 60 male rats (weight: 200-220 g) were divided into six groups and treated for 14 days. The control (group I) and 5-FU (group II) groups received distilled water and 5-FU, respectively. The other four groups were orally administered with CsE, CsH, CsE+5-FU, and CsH+5-FU (groups III to VI), respectively by gavages based on a daily schedule. The 5-FU-induced oxidative damage was evaluated by changes in the weight and food and water intake during the treatment and antioxidant parameters in the liver and serum of the treated rats. The obtained data indicated that the administration of CsH and CsE significantly improved liver function and defense system of antioxidants by attenuating the levels or activities of MALONDIALDEHYDE, superoxide anion, aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase and decrease of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione S-transferase, total antioxidant capacity, glutathione, total protein, and albumin in the liver and serum, induced by 5-FU treatment. The obtained data of the current study suggested that CsH and CsE play a protective role in the imbalance elicited by 5-FU and can be used as alternative/complementary supplements with 5-FU to reduce oxidative damages which is the consequence of reactive oxygen species production in cancerous patients. FRENCH: Ré sumé : La chimiothé rapie est la principale approche pour le traitement du cancer; cependant, elle provoque souvent des dommages oxydatifs dé sagré ables. Par consé quent, le dé veloppement d'une thé rapie alternative / complé mentaire efficace avec une efficacité de suppression tumorale amé lioré e et des effets indé sirables moindres est hautement né cessaire. Ré cemment, il a é té dé montré que l'extrait de Cyrtopodion scabrum (CsE) est un mé dicament suppresseur de tumeur efficace et sé lectif. La pré sente é tude a examiné l'activité antioxydante de l'homogé nat de Cyrtopodion scabrum (CsH) et de la CsE et leurs effets sur l'atté nuation du dysfonctionnement hé patique induit par le 5-fluorouracile (5-FU) chez les rats. Un total de 60 rats mâ les (poids: 200-220 g) ont é té divisé s en six groupes et traité s pendant 14 jours. Les groupes té moins (groupe I) et 5-FU (groupe II) ont reç u respectivement de l'eau distillé e et du 5-FU. Les quatre autres groupes ont é té administré s par voie orale avec CsE, CsH, CsE+5-FU et CsH+5-FU (groupes III à VI) par des gavages basé s sur un programme quotidien. Les dommages oxydatifs induits par le 5-FU ont é té é valué s par les modifications du poids et de la prise de nourriture et d'eau pendant le traitement et les paramè tres antioxydants dans le foie et le sé rum des rats traité s. Les donné es obtenues ont indiqué que l'administration de CsH et CsE amé liorait considé rablement la fonction hé patique et le systè me de dé fense des antioxydants en atté nuant les niveaux ou les activité s du malondialdé hyde, de l'anion superoxyde, de l'aspartate aminotransfé rase, de l'alanine aminotransfé rase et de la phosphatase alcaline et de la diminution de la superoxyde dismutase, de la catalase, glutathion peroxydase, glutathion ré ductase, glutathion S-transfé rase, capacité antioxydante totale, glutathion, proté ines totales et albumine dans le foie et le sé rum, induites par un traitement au 5-FU. Les donné es obtenues de la pré sente é tude suggè rent que la CsH et la CsE jouent un rô le protecteur dans le dé sé quilibre provoqué par le 5-FU et peuvent ê tre utilisé es comme supplé ments alternatifs / complé mentaires avec le 5-FU pour ré duire les dommages oxydatifs qui sont la consé quence de la production d'espè ces ré actives de l'oxygè ne chez les patients cancé reux.