KAWASAKI DISEASE (KD) is an acute vasculitis syndrome of unknown etiology. It occurs in infants and young children, affecting mainly small and medium-sized arteries, particularly the coronary arteries. Generalized microvasculitis occurs in the first 10 days, and the inflammation persists in the walls of medium and small arteries, especially the coronary arteries, and changes to coronary artery aneurysms.We report the case of a 10-month-old girl referred to our center three months after the onset of DISEASE due to the aneurysms of the coronary arteries. During the acute phase of her illness, she received 2 gr/kg intravenous gamma globulin; and after her referral to us, the patient was treated by antiaggregant doses of acetylsalicylic acid (ASA) (5 mg/kg) and Warfarin (1 mg/ daily). At three months’ follow-up, the aneurysms still persisted in the echocardiogram.

Background: KAWASAKI DISEASE is an acute multisystem vascular syndrome of unknown etiology that is the leading cause of acquired heart DISEASE in children of developed counties.Objectives: We aimed to evaluate the epidemiological characteristics and clinical manifestations of KAWASAKI DISEASE in children residing in the southwest of Iran.Patients and Methods: In this retrospective study, we reviewed the medical records of all children with KAWASAKI DISEASE who had been admitted to the main children’s hospital of Ahvaz, southwest Iran, from March 2000 to March 2010. Data regarding clinical and epidemiological characteristics, management, and the outcome of DISEASE for each patient were obtained. The patients were divided into cardiac and non-cardiac groups based on echocardiographic results.Results: In total, 104 patients with KAWASAKI DISEASE (66 boys and 38 girls) were enrolled in this study. The male to female ratio was 1.7: 1. The mean±SD age of the patients was 33.6±24.2 months. Most (87.2%) cases were from urban areas. The DISEASE occurred more frequently during winter and spring. Furthermore, 61.5% of the children had the criteria of classic KD, and 38.5% were labeled as incomplete KD. The mean±SD of the duration of hospital stay was 6.9±2.4 days. The mean time between illness and admission to the hospital was 6.47±2.6 days. The most common sign was fever, followed by conjunctivitis and oral changes. In total, 20% of the patients had cardiac abnormalities. There was no significant statistical difference between the cardiac and non-cardiac groups according to age, sex, clinical manifestations, laboratory findings, and cessation of fever. The duration of hospital stay and the time between onset of illness and diagnosis were longer in the cardiac group. All patients received intravenous immunoglobulin and aspirin. Only one patient continued to have cardiac abnormalities after 6 months of follow-up.Conclusions: KAWASAKI DISEASE is not rare in southwest of Iran. The age, gender distribution and clinical findings are similar to that of other reports. Patients with cardiac abnormalities had delayed treatment and prolonged hospital stays.

KAWASAKI DISEASE is a multi system disorder with varying clinical expressions. This DISEASE is an acute systemic vasculitis of unknown etiology that has recently recognized as a leading cause of acquired heart DISEASE in children of many developed countries. We describe an unusual instance of hair loss in a patient with KAWASAKI DISEASE. A 26 months old boy developed prolonged high fever, bilateral conjunctival infection, arthralgia and erythromatosis skin rash. He was admitted to the hospital with the diagnosis of KAWASAKI DISEASE. Laboratory results included an erythrocyte sedimentation rate (ESR) above 100 and platelet count > 1000,000. The patient developed acute and unprovoked scalp hair loss. He was treated with intravenous immunoglobulin (IVIG) 2 g/kg and aspirin 100 mg/kg/day with complete improvement of signs and symptoms. This report documents hair loss as an uncommon presentation of KAWASAKI DISEASE.

KAWASAKI DISEASE or mucucutaneus lymph node syndrom in infants is a febrile DISEASE which occurs before age of 10. Inflammatory coronary DISEASE is a rare and late seqaul in about 1% to 3% of patients and leads to aneurysm and coronary thrombosis in adolesence. This is a report of a 25 year old man who referred to hospital with chest pain and symptoms of acute myocardial infarction. He was admitted to CCU. ECG showed acute Anterior MI and he received conventional treatment. Echocardiography in discharge showed 40% of EF with anteroapical LV wall akinesia. Coronary angiography was done and LAD aneurysm with EF about 40% was revealed. CABC and aneurysmectomy was also preformed. Pathologic report was compatible with latent phase of KAWASAKI DISEASE.  

Background: KAWASAKI DISEASE is a systemic vacuities of unknown etiology and a major cause of acquired heart DISEASE in developed countries.Aim: The aim was to describe the epidemiology, management and the rate of cardiac complications of KAWASAKI DISEASE.Methods: According to a cross-sectional study, between 1995-2000, we recorded 45 children with KAWASAKI DISEASE who were admitted to pediatric ward of Al-Zahra medical center in Isfahan, Iran.Results: Out of 45 patients, there was 29 (64.4%) boys and 16 (35.6%) girls giving a ratio of 1.8:1 (p<0.05). The age range was between 0.5 to 11 years with a mean (SD) of 4.14 (2.46). The peak incidence occurred in second year of life. A total of 21 cases of cardiac involvement were detected, including pericardial effusion (5 cases), mitral regurgitation (6 cases) and coronary artery ancurysms (CAA) (10 cases). CAA in patients who received intravenous immunoglobulin in the first 10 days was less than untreated groups or patients treated later on (P<0.05). Laboratory investigations showed leucocytosis, thrombocytosis and a raised erythrocyte sedimentation rate in the most patients.Conclusion: CAA in this study was higher than in other reports. Risk of CAA will increase, if the diagnosis and treatment are delayed more than 10 days.