Introduction: The incidence of End-Stage Renal Disease (ESRD) varies markedly according to the age, race and sex of the population as well as the geographical characteristics of the place where they live. Low socio-economic status is associated withthe occurrence of several different chronic diseases, but evidenceregarding renal disease is scant. This study was performed to determine the relationship between the level of patient’s family education and INCOME with the etiology of ESRD.Materials and Methods: A cross sectional study was conducted on 62 patients (30 Boys and 32 Girls) with chronic renal failure who were under dialysis treatment. A control group consisting of 400 students was also enrolled in the study. Socioeconomic data were obtained from both groups by using a questionnaire. Meanwhile, the cause of renal failure and the kind of dialysis were also determined for the patients. Socioeconomic features were compared in both the patients and the control group by using student T-Test, Chi-square, Fisher Exact Test and logistic regression analysis.Results: In the dialysis group, there were remarkably more children from families with either one parent or without any supervisor, as compared with the control group) P<0.001).The level of family education in the dialysis group and control group was 10.6 and 13.3 years of schooling, respectively (P<0.001). Dialysis patients were either tenants or were living in houses smaller than the control group’s (P<0.001). In addition, the household’s monthly INCOME for the case group was lower than that of the control group and only 3% of the patients were living in the socioeconomic areas of high classes (P<0.001).Conclusion: The dialysis patients’ families had lower socioeconomic level in comparison with the healthy population. The high prevalence of ESRD in these families may be related to the lack of access to hygienic facilities, the parents’ lack of sufficient knowledge and inattentiveness which may lead to delayed diagnosis of the disease, and incomplete treatment of the primary disease which may, in turn, develop ESRD.