Background and Objectives: During the last decade new bonding techniques beside sutures, staples and clips have been introduced to the modern operating room, including chemical and biological glues. But these methods do not necessarily provide a complete wound seal and adequate strength and had problems with times reactivity and infection. However the application of wavelength-specific chromophores provides a differential absorption between the dyed region and the surrounding tissue. An example of this technique is that while an extended area may be irradiated by the laser but the energy is only absorbed selectively by the dyed region. This paper describes an invitro study using a 10 CW ~ 800 nm diode laser in conjugation with an indocyanine green (ICG) dye doped with albumin protein solder to repair sheep skin specimen. The effect of temperature, power density, type of treatment, number of scan and scan velocity are studied and discussed.Material & Methods: Liquid protein solder was prepared from 25% BSA (Merck, Germany) and ICG dye (Sigma, Alderich-Germany) 0.25 mg/ml mixed in 5cc deioniozed water. The protein solder was stored in a light proof vial in a refrigerator until required. The solder was applied on the 2*20 mm2 incision by a micropipette. The laser output was focused buy a suitable optics into the rectangular image which treated the skin in static and dynamic modes. The surface temperature was measured by a digital thermometer (CHY 502A1, Taiwan) and crossed checked by a non-content laser thermometer. Mean peak temperature produced by the protein solder surface during the laser procedure, the tensile strength (s) of healed incision after 2 hours for two modes of treatments just before their point of rupture under the applied load were measured.Results: However, in practice to have an optimal condition for skin closure some parameters must be carefully studied such as number of scans (Ns) and scan velocity (Vs) in dynamic mode. The results showed that the tissue tensile strength increases by increasing both Ns and the laser power density. But also it has equally been shown that at lower Vs, hence higher temperature, a higher value of s is achieved. It is therefore imperative to consider the trade off between the scan velocity and the surface temperature for achieving the best optimum operating condition.Conclusions: Thus, it can tentatively be concluded that since the skin temperature should not exceed ~90C at any time of work, then the acceptable conditions in our experiment would correspond to I~ 47 Wcm-2, s= gr, Ns= 8, Vs=0.3mms-1.