The aim of this study was to clarify the influences of marital Quality and its dimensions on the Health Related Quality of Life. Marriage is one of the most significant social relationships in which individuals engage. Therefore, the most important contextual factor influencing the Health Related Quality of Life is marital Quality. The research population consisted of all married people of Isfahan city in 2014, which had children in elementary-school and at least had secondary school education. The participants were 338 people, who were randomly selected from the parents of elementary school pupils in Isfahan using cluster sampling. The instruments used in this study were the revised dyadic adjustment scale (RDAS), the marital happiness scale (MHS), and the Persian version of the WHOQOL-BREF. The adjusted coefficient of determination (Δ R2) between components of marital Quality and physical Health, psychological Health, and social relations was obtained as equal to. 57, . 30, and. 22, respectively, all of which were significant. This coefficient of relationship between components of marital Quality and environmental Health was obtained as equal to. 001, which is not significant. Also, the results showed that gender played a moderator role in the effects of marital Quality on physical and psychological Health. The findings showed that marital Quality is an important factor to estimate the Health Related Quality of Life.