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مرکز اطلاعات علمی SID1
اسکوپوس
مرکز اطلاعات علمی SID
ریسرچگیت
strs
Issue Info: 
  • Year: 

    2002
  • Volume: 

    20
  • Issue: 

    2
  • Pages: 

    185-192
Measures: 
  • Citations: 

    0
  • Views: 

    591
  • Downloads: 

    116
Abstract: 

Background: Ameloblastoma an odontogenic tumor of ectodermal origin has been reported to arise, on rare occasions, in a primordial or dentigerous cyst of a young person. Numerous authors have suggested differing nomenclatures for these ameloblastomas and have sought to describe and classify the clinical and histopathologic features. These tumors have been characterized as a distinct variant exhibiting less aggressive behavior and a lower rate of recurrence than conventional ameloblastoma.Aims: This study was designed to look at the HUMAN papilloma virus as a caurse for Ameloblastoma.Materials and Methods: Samples of Ameloblastoma tumors were traced from the filing system in path lab Beheshti Dental School. Using PCR technique a search was carried out to dated HPV in DNA of samples.Results: There was a clear relationship between the rates of HPV in Ameloblastoma cases.Conclusion: HPV could be a preparing factor for Ameloblastoma.

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Issue Info: 
  • Year: 

    2017
  • Volume: 

    35
  • Issue: 

    427
  • Pages: 

    440-446
Measures: 
  • Citations: 

    0
  • Views: 

    2244
  • Downloads: 

    291
Abstract: 

Background: Transformation and differentiation of activated B-cell to plasmacells and also memory cells depend on signaling from B-cell receptors. The signals from antigen and cytokine receptors on the surface of B cells lead to induce the expression of specific transcription factors, which finally determine the fate of B cells.Methods: Peripheral blood mononuclear cells (PBMC) were isolated via ficoll gradient and then purified B cells were separated using magnetic-activated cell sorting (MACS). Pure B cells were cultured in Roswell Park Memorial Institute 1640 (RPMI1640) culture media at the presence of purified anti-HUMAN CD40 antibody and anti-immunoglobulin M f (ab) ´2 or lipopolysaccharide (LPS) and anti-HUMAN CD40 antibody that induced B-cells differentiation to plasmablasts which was assessed with 3 markers (CD38+, CD27+, IgM-) and analyzed via flow cytometry. Findings: In stimulation of B cells with purified anti-HUMAN CD40 antibody and anti-IgM f (ab) ´2 or LPS through cross-linking B-cell receptor, the majority of B cells remained alive and differentiated to another lineage of B cells (plasmablast: CD38+, CD27+, IgM-). There was no significant statistical difference between expressions of plasmablast markers in two states of stimulation.Conclusion: B cells can be stimulated and differentiated to plasmablasts in vitro similar to in vivo condition. However, to achieve the best outcome in the differentiation of B cells, we should consider the nature of stimulator, the time of incubation, and the type of stimulators.

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Journal: 

YAFTEH

Issue Info: 
  • Year: 

    2006
  • Volume: 

    8
  • Issue: 

    2 (28)
  • Pages: 

    61-69
Measures: 
  • Citations: 

    0
  • Views: 

    756
  • Downloads: 

    197
Abstract: 

Background: Asthma is recognized as a common cause of disability, of great economic cost, and of preventable deaths. In this study we aimed to test our hypothesis to evaluate the relationship between the HUMAN Platelet Antigen-1(HPA-I) polymorphism and bronchial asthma and its severity, which would suggest genetic variances that may be responsible for expression or activation of these receptors, so play a role in explaining the suggested genotypic differences in the risk of bronchial asthma occurrence.Materials and methods: To investigate the relation between the HPA-I polymorphism and bronchial asthma, we conducted a case-control study of 110 patients with bronchial asthma and 129 non-asthmatic outpatient controls, which were participated voluntarily in this study. After the participants answered a questionnaire aimed at identifying their age, sex, clinical signs and symptoms to identify asthma severity, a trained observer assessed airway reversibility in asthmatic patients. To determine HPA-I allele frequencies (la, Ib) and genotyping for Ia+Ia, Ia+Ib and Ib+Ib in both patients and controls, a blood sample was sent to the laboratory.Results: It was found that the dyspnea was the most common symptom in asthmatic patients, recurrent episodic wheezing (93.6%), cough (90%) and nocturnal symptom (89.1%) were other more common symptoms respectively. Assessment of HPA-1 allele frequencies (Ia, Ib) and genotyping for Ia+la, Ia+Ib and Ib+Ib showed no differences in both patients and controls (P>0.05). The rate of Ia allele frequency and Ia+Ia genotype had a direct relationship with asthma severity. Conclusion: We observed strong association between HPA-1 a allele and asthma severity, but no association between the presence of HPA-1 polymorphism and bronchial asthma.

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گارگاه ها آموزشی
Issue Info: 
  • Year: 

    2014
  • Volume: 

    31
  • Issue: 

    270
  • Pages: 

    2362-2372
Measures: 
  • Citations: 

    1
  • Views: 

    896
  • Downloads: 

    222
Abstract: 

Background: In HUMAN immunodeficiency virus HIV-infected patients, oropharyngeal candidiasis is a common infection. The aim of present study was molecular typing of Candida albicans isolates recovered from HIV-infected patients with oropharyngeal candidiasis and comparing the molecular patterns of fluconazole-resistant and susceptible isolates.Methods: The molecular typing of genomic DNA of 48 Candida albicans isolated from HIV-infected patients were assessed by the random amplified polymorphic DNA-polymerase chain reaction (RAPD-PCR) fingerprinting. Sensitivity of strains to fluconazole was determined by the broth microdilution method.Findings: We detected two main clusters and seven sub-clusters, comprising 24 genotypes of Candida albicans strains. No associations between the patterns of strains isolated from hospitalized patients and outpatients and clinical forms of oropharyngeal candidiasis were detected. There was also a relative correlation between fluconazole susceptibility and strain clustering.Conclusion: The presence of several genotypes of Candida albicans in HIV-infected patients would lead to problems in the treatment and prevention of oral candidiasis. The lack of correlation between genotypes and clinical forms of oropharyngeal candidiasis shows the importance pf host condition in the pathogenesis of candida infections. The lack of phylogenetic relationships among strains from hospitalized patients approves endogenous origin of candida infection. The results indicate that HIV-infected patients have favorable conditions for the growth and proliferation of different genotypes of Candida albicans. In conclusion, molecular typing using RAPD-PCR revealed a genomic heterogeneity in the Candida albicans clinical isolates studied in HIV-infected patients.

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Issue Info: 
  • Year: 

    2005
  • Volume: 

    8
  • Issue: 

    5 (33)
  • Pages: 

    347-352
Measures: 
  • Citations: 

    0
  • Views: 

    635
  • Downloads: 

    154
Abstract: 

Background and Objective: Studies concerning the relation between mycosis fungoides (MF) and its leukemic form Sezary syndrome (SS) and infection with HUMAN T lymphotropic virus 1 (HTLV 1) Have yielded different findings. The objective of this study is to determine the frequency of HTLV 1 infection in MF patients. Materials and Methods: In a case-control study, 150 clinically and histopathologically confirmed MF patients and 150 normal individuals were evaluated and compared for the HTLV 1 infection. Sera of the participants were taken and evaluated by ELISA method. Positive results were confirmed by Western blot. Results: HTLV 1 infection was detected in 3 of 150 MF patients and 2 of normal participants. Conclusion: This study shows no association between HTLV 1 infection and MF in Iranian patients.      

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Issue Info: 
  • Year: 

    2021
  • Volume: 

    17
  • Issue: 

    1
  • Pages: 

    70-79
Measures: 
  • Citations: 

    0
  • Views: 

    171
  • Downloads: 

    136
Abstract: 

Background: Infectious diseases, including acquired immunodeficiency syndrome (AIDS), have affected HUMAN societies today, and no cure has yet been found. The disease is caused by a virus that infects the immune system. Our goal is to establish a relationship between mathematics and the impact of the virus on the immune system. Methods: In this study, several mathematical models have been studied and their relationship with the function of the HIV virus has been investigated. In these models, the contamination of immune cells, virus proliferation, production of infected cells, and the role of cellular and humoral immune systems in reducing cell proliferation have been considered. Findings: Studies show that the process of infection of immune cells and macrophages with the virus and even treatment to control the disease can also be mathematically illustrated. After writing the mathematical model and analyzing the model in manual and computer forms, one could find important parameters in reducing or increasing the speed of this disease and controlling it, in addition to reducing the spread of the disease and delaying the deaths. Conclusion: In order to better analyze this disease, all the effective factors in the model can be introduced and expressed as a broad mathematical model, but with the increase of these factors, it will be much more difficult to analyze them. However, by assuming some factors of the model to be constant, it will be easier. The purpose of this article is to simplify the process and mathematical modeling of AIDS and its general understanding for those interested in modeling.

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strs
Author(s): 

SALEHNIA M. | MOAZENI S.M.

Journal: 

DANESHVAR MEDICINE

Issue Info: 
  • Year: 

    2002
  • Volume: 

    9
  • Issue: 

    38
  • Pages: 

    25-32
Measures: 
  • Citations: 

    0
  • Views: 

    743
  • Downloads: 

    116
Abstract: 

The aim of this study was to investigate the effects of daily injection of hMG on the development of follicles in transplanted vitrified mouse ovary to improve the in vivo growth of primordial and primary follicles. Ovaries from 8-10 weeks age and NMRI mice were vitrified by using a solution of RPMI containing 30% ((W/V) follicles 70, 0.5 M sucrose, 10.7% (V/V) acetamid and 40% (V/V) ethylene glycol (EGFS40%) and stored in liquid nirtogen. After thawing by I M sucrose solution and equilibration with RPIM medium, the frozen-thawed and fresh ovarian tissues were auto grafted intraperitonealy. One day after transplantation, stimulation was started by injection of 5 IU hMG (Personal 500, Serono) in one group of grafted mouse each other day for 9 days. Stimulated and non-stimulated animals were sacrificed during 3, 5, 7, 9 and 11 days after hMG injection. The vitrified and non-vitrified grafts and fresh tissue were fixed in Bouin’s fixative and processed for histology. In the fresh control ovaries almost all of the follicles appeared normal in the various development stages. In vitrified ovaries there were no morphologically differences between transplanted tissue with or without hormonal injection. Three days after passing the transplantation, a lot of large prenatal and antral follicles were degenerated but after 10 days just normal primordial and primary follicles were observed, the stroma was devoid the necrotic cells. The grafted ovarian tissues were invaded by a lot of fat and fibrous cells. Thus vitrification procedure is a useful and efficient procedure for cry preservation of ovarian tissues, however it is necessary to improve the maturation of primordial and primary follicles by changing the site of transplantation or hormonal stimulation with effective dosages.

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Author(s): 

ARDALAN MOHAMMAD REZA

Issue Info: 
  • Year: 

    2012
  • Volume: 

    34
  • Issue: 

    1
  • Pages: 

    109-111
Measures: 
  • Citations: 

    0
  • Views: 

    748
  • Downloads: 

    227
Abstract: 

HTLV-1 (HUMAN T-cell lymph tropic virus) is the cause of two recognized HUMAN diseases; Adult T cell Leukemia/Lymphoma (ATLL) and HTLV-1 associated myelopathy (HAM) syndromes. Here, we report a patient who presented with confluent-violaceous maculopapular skin lesions, arthralgia and positive serology for rheumatoid factors. Later, the patient presented with thrombocytopenia anemia, walking disability and renal involvement. Future workup discovered the diagnosis of ATLL lymphomatous involvement and HTLV-1 positivity.

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Issue Info: 
  • Year: 

    1385
  • Volume: 

    13
  • Issue: 

    2 (سومین کنگره اپیدمیولوژی)
  • Pages: 

    63-63
Measures: 
  • Citations: 

    0
  • Views: 

    332
  • Downloads: 

    30
Abstract: 

مقدمه و هدف: بروسلوز امروزه در جهان یکی از مهمترین بیماریهای مشترک بین انسان و حیواناتی چون گوسفند، بز و گاو است. بار بیماری به خصوص در مناطق اندمیک بسیار قابل توجه می باشد.هدف: این مطالعه با هدف شناسایی ارتباط بین پراکندگی حیوانات اهلی و میزان بروز بروسلوز انسانی در روستاهای شهرستان بردسیر (استان کرمان) انجام گرفت.روش کار: این مطالعه مقطعی بر اساس اطلاعات اکولوژیکی روستاها طراحی گردید. اطلاعات جمع آوری شده از هر روستا شامل چهار بخش، تعداد بروسلوز انسانی گزارش شده، وضعیت اقتصادی - اجتماعی خصوصیات چهارپایان و موقعیت جغرافیایی بود. داده های فوق از طریق سیستم بهداشت و درمان، سازمان دامپزشکی و مرکز آمار کشور گردآوری شد. روستاهایی که در طول سه سال گذشته (4-2002) حداقل یک مورد بروسلوز انسانی داشتند، به عنوان "روستای اندمیک" و بقیه به عنوان کنترل در نظر گرفته شدند. با استفاده از مدلسازی تک/ چند متغیره لجستیک رگرسیون (Stata v.8)، ارتباط فاکتورهای مختلف با نوع روستا مورد ارزیابی قرار گرفت. نقشه خطر بروسلوز انسانی با استفاده از آنالیز مکانی (Spatial A.) در نرم افزار Arcview GIS ترسیم گردید.یافته ها: میزان بروز سالانه بروسلوز 141.6 در 100000 نفر بود. تقریبا %3.6 روستاها، حداقل یک مورد بیماری را در سه سال گذشته داشتند. ارتباط معنی دار بین روستای اندمیک و تراکم تعداد گاو مشاهده شد. به عبارت دیگر، با افزایش تراکم گاو از تعداد 20 راس در کیلومتر مربع، میزان بروز بیماری به %29 افزایش می یافت (P<0.001). برخلاف نتایج آنالیز تک متغیره، نسبت شانس (OR) تصیح شده با آنالیز چند متغیره، رابطه معنی داری را بین وضعیت اقتصادی - اجتماعی و روستای اندمیک بودن نشان نداد. علاوه بر تراکم گاو P=0.007)، (OR=1.81، تعداد جمعیت انسانی P<0.001)،(OR=1.94  نیز یک ریسک فاکتور مستقل برای بروز بیماری محسوب می شد.بحث و نتیجه گیری: تعداد جمعیت حیوانی با بروز بروسلوز انسانی ارتباط دارد، وضعیت اقتصادی - اجتماعی روستانشینان یک عامل مخدوش کننده در رابطه بین خصوصیات چهارپایان و بروسلوز انسانی می باشد. استفاده از سیستم اطلاعات جغرافیایی، به عنوان ابزاری برای یکپارچه کردن اطلاعات سازمانهای مختلف، در جهت کنترل و مراقبت موثرتر بیماری بروسلوز توصیه می گردد.

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Issue Info: 
  • Year: 

    1388
  • Volume: 

    14
  • Issue: 

    45
  • Pages: 

    61-64
Measures: 
  • Citations: 

    0
  • Views: 

    1007
  • Downloads: 

    218
Abstract: 

سابقه و هدف: مداخلات رفتاری و روانی که باعث کاهش استرس شود، می تواند در بالا بردن کفایت دستگاه ایمنی و به تاخیر افتادن پیشرفت HIV موثر باشد. کاهش استرس براساس هوشیاری مداخله ای رفتاری است که بر مبنای تمرینات توجه و تمرکز به خود استوار می باشد. در این مطالعه، میزان تاثیر برنامه "کاهش استرس براساس هوشیاری" بر وضعیت CD4 بیماران مبتلا به HIV/AIDS در باشگاه یاران مثبت بیمارستان امام خمینی(ره) در سال 1386 بررسی شد.روش کار: 10 نفر از بیماران HIV مراجعه کننده به مرکز مشاوره بیماریهای رفتاری در یک مطالعه مقدماتی در بیمارستان امام خمینی(ره) شرکت نمودند. از این تعداد 4 نفر به عللی نظیر عدم شرکت مرتب در جلسات دوره آموزشی، استفاده مجدد از متادون و نیز مشکلات خانوادگی از مطالعه خارج گردیدند و در نهایت 6 نفر دوره را به پایان رساندند. برنامه کاهش استرس براساس هوشیاری یک برنامه 8 هفته ای با جلسات 2 ساعت در هفته بود که در این روش مهارتهای مراقبه بررسی بدن، یوگا و مراقبه نشسته آموزش داده شد.میزان CD4 بیماران قبل و بعد از درمان و سپس در فواصل زمانی 3 ماه، 6 ماه، 9 ماه و 12 ماه بعد از درمان اندازه گیری شد. داده ها با استفاده از paired t test تجزیه و تحلیل شد و p<0.05 سطح معنی دار اختلاف ها تلقی گردید.یافته ها: در این مطالعه 6 بیمار 3) زن و 3 مرد) بررسی شدند. میانگین سنی بیماران شرکت کننده برابر با 35+7.7 سال بود. میانگین CD4 بیماران در قبل و بعد از مداخله، پی گیری سه ماهه، شش ماهه، نه ماهه، دوازده ماهه به ترتیب برابر 549±173.6، 640.2±189.4، 655.3±183.4، 638±167.4، 619.3±163.2 و 595.2±165.6 بود. افزایش مقدار CD4 در فواصل پی گیری نسبت به قبل از مداخله از لحاظ آماری معنی دار بود.نتیجه گیری: در مطالعه ما میزان CD4 در فواصل زمانی مختلف بعد از درمان نسبت به قبل از درمان افزایش معنی داری داشته است. انجام مطالعات با حجم نمونه بیشتر ضروری به نظر می رسد.

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