Background and Objective- High-dose chemotherapy with stem cell rescue has emerged as the treatment of choice for patients with refractory and relapsed non-Hodgkin’s LYMPHOMA (NHL). To evaluate the efficacy and toxicity of a novel chemotherapy regimen with mesna, Ifosfamide novantrone and etoposide (MINE) in patients with relapsed NHL previously treated with adriamycin-based regimens.
Methods-Forty-six patients with relapsed NHL were treated in this study. The median age was 42 years (range 13-65). Twenty-eight patients (60.8%) had high grade, 10 (21.7%) had low grade and the rest had intermediate grade LYMPHOMA. The program utilized cyclic administration of ifosfamide 1.33 gm/m2 day 1-3, mesna 1.33 gm/m2 day 1-3, etoposide 100 mg/msup>2 day 1-3, novantrone 12 mg/m2 day 1. Cycles were repeated every 3 weeks for 6 cycles. Mean while, adequate hydration was also provided.
Results-The overall response rate was 65.2% (30 patients). Complete response was achieved in 30.4% (14 patients) and a partial response in 34.8%. The median survival period was 7 months. Grade III neutropenia was seen in 10 patients (21.7%) and grade IV in 1 patient who died of treatment-related toxicity.
Conclusion-MINE combination is an effective and well tolerated treatment for patients with relapsed NHL who have no chance for bone marrow transplantation.